scholarly journals Effects of let‑7c on the proliferation of ovarian carcinoma cells by targeted regulation of CDC25a gene expression

2018 ◽  
Author(s):  
Wei Zhang ◽  
Qingru Zeng ◽  
Zhenying Ban ◽  
Jing Cao ◽  
Tianjiao Chu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ovarian Carcinoma ◽  
Carcinoma Cells ◽  
Ovarian Carcinoma Cells

Suppressive Effects of Neopterin on Inducible Nitric Oxide Synthase Gene Expression in Ovarian Carcinoma Cells in vitro

Pteridines ◽  
2001 ◽  
Vol 12 (4) ◽  
pp. 140-145 ◽  
Author(s):  
Josef Rieder ◽  
Anton Amann ◽  
Michaela Schloesser ◽  
Monika Czechowski ◽  
Maja Seibel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Ovarian Carcinoma ◽  
Inducible Nitric Oxide Synthase ◽  
Carcinoma Cells ◽  
Ovarian Carcinomas ◽  
Ovarian Carcinoma Cells ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Abstract In a Number of malignant diseases including ovarian carcinomas, increased serum or urine levels of neopterin serve as a valuable marker for the state of activation of the cellular immune system. Reported correlations benveen elevated neopterin concentrations and shorter survival time of the tumor host might be explained by direct biochemical actions exhibited by the pteridine compound. In the present study, we investigated the influence of neopterin on inducible nitric oxide synthase (iNOS) gene expression in two ovarian carcinoma cell lines. Qualitative and quantitative analyses of iNOS as well as measurements of nitric oxide (NO) metabolites in the cell supernatant revealed an inhibitory effect of neopterin (1000 11M) on NO generation induced by a combination ofinterferon-γ (100 U/ml), tumor necrosis factor-a (500 U/ml), and interleukin-1β (10 U/ml). Since NO is most likely involved in apoptotic cell death in ovarian carcinoma cells, it is conceivable that suppression of NO synthesis represents a biochemical mechanism mediated by neopterin that is advantageous to tumor progression and thus harmful to the host.

Potentiation of Azidothymidine Cytotoxicity in Cisplatin-resistant Human Ovarian Carcinoma Cells

1990 ◽  
Vol 2 (10) ◽  
pp. 339-343 ◽  
Author(s):  
Kevin J. Scanlon ◽  
Tadao Funato ◽  
Babak Pezeshki ◽  
Takeshi Tone ◽  
Lawrence C. Sowers
Keyword(s):  
Ovarian Carcinoma ◽  
Carcinoma Cells ◽  
Ovarian Carcinoma Cells ◽  
Human Ovarian Carcinoma ◽  
Human Ovarian Carcinoma Cells

In Vitro and In Vivo Effect of Palladacycles: Targeting A2780 Ovarian Carcinoma Cells and Modulation of Angiogenesis

2021 ◽  
Vol 60 (6) ◽  
pp. 3939-3951
Author(s):  
Francisco Reigosa-Chamorro ◽  
Luís R. Raposo ◽  
Paula Munín-Cruz ◽  
M. Teresa Pereira ◽  
Catarina Roma-Rodrigues ◽  
...  
Keyword(s):  
Ovarian Carcinoma ◽  
Carcinoma Cells ◽  
Ovarian Carcinoma Cells
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