scholarly journals Pathological prognostic factors in the second British Stomach Cancer Group trial of adjuvant therapy in resectable gastric cancer

1995 ◽  
Vol 71 (5) ◽  
pp. 1106-1110 ◽  
Author(s):  
CC-W Yu ◽  
DA Levison ◽  
JA Dunn ◽  
LC Ward ◽  
M Demonakou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Adjuvant Therapy ◽  
Stomach Cancer ◽  
Cancer Group ◽  
Resectable Gastric Cancer ◽  
Group Trial

The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up

The Lancet ◽  
1994 ◽  
Vol 343 (8909) ◽  
pp. 1309-1312 ◽  
Author(s):  
M.T. Hallissey ◽  
J.A. Dunn ◽  
L.C. Ward ◽  
W.H. Allum ◽  
British Stomach Cancer Group
Keyword(s):  
Gastric Cancer ◽  
Stomach Cancer ◽  
Adjuvant Radiotherapy ◽  
Cancer Group ◽  
Resectable Gastric Cancer ◽  
Group Trial

Prognostic factors in resectable gastric cancer: Results of EORTC study no. 40813 on FAM adjuvant chemotherapy

1995 ◽  
Vol 2 (6) ◽  
pp. 495-501 ◽  
Author(s):  
Mario Lise ◽  
Donato Nitti ◽  
Alberto Marchet ◽  
Tarek Sahmoud ◽  
Nicole Duez ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Adjuvant Chemotherapy ◽  
Resectable Gastric Cancer

Impact of the Extent of Surgery and Postoperative Chemoradiotherapy on Recurrence Patterns in Gastric Cancer

2010 ◽  
Vol 28 (14) ◽  
pp. 2430-2436 ◽  
Author(s):  
Johan L. Dikken ◽  
Edwin P.M. Jansen ◽  
Annemieke Cats ◽  
Berdine Bakker ◽  
Henk H. Hartgrink ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Local Recurrence ◽  
Separate Analysis ◽  
Two Phase ◽  
R1 Resection ◽  
Cancer Group ◽  
Significant Difference ◽  
Resectable Gastric Cancer ◽  
Extent Of Surgery ◽  
Recurrence Patterns

PurposeThe Intergroup 0116 trial has demonstrated that postoperative chemoradiotherapy (CRT) improves survival in gastric cancer. We retrospectively compared survival and recurrence patterns in two phase I/II studies evaluating more intensified postoperative CRT with those from the Dutch Gastric Cancer Group Trial (DGCT) that randomly assigned patients between D1 and D2 lymphadenectomy.Patients and MethodsSurvival and recurrence patterns of 91 patients with adenocarcinoma of the stomach who had received surgery followed by radiotherapy combined with fluorouracil and leucovorin (n = 5), capecitabine (n = 39), or capecitabine and cisplatin (n = 47) were analyzed and compared with survival and recurrence patterns of 694 patients from the DGCT (D1, n = 369; D2, n = 325). For both groups, the Maruyama Index of Unresected Disease (MI) was calculated and correlated with survival and recurrence patterns.ResultsWith a median follow-up of 19 months in the CRT group, local recurrence rate after 2 years was significantly higher in the surgery only (DGCT) group (17% v 5%; P = .0015). Separate analysis of CRT patients who underwent a D1 dissection (n = 39) versus DGCT-D1 (n = 369) showed fewer local recurrences after chemoradiotherapy (2% v 8%; P = .001), whereas comparison of CRT-D2 (n = 25) versus DGCT-D2 (n = 325) demonstrated no significant difference. CRT significantly improved survival after a microscopically irradical (R1) resection. The MI was found to be a strong independent predictor of survival.ConclusionAfter D1 surgery, the addition of postoperative CRT had a major impact on local recurrence in resectable gastric cancer.

TOPGEAR: An international randomized phase III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer (AGITG/TROG/EORTC/NCIC CTG).

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. TPS4141-TPS4141 ◽  
Author(s):  
Trevor Leong ◽  
Mark Smithers ◽  
Michael Michael ◽  
Val Gebski ◽  
Alex Boussioutas ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Therapy ◽  
Phase Ii ◽  
Preoperative Chemotherapy ◽  
Gastroesophageal Junction ◽  
Phase Iii ◽  
Standards Of Care ◽  
Current Status ◽  
Quality Assurance Program ◽  
Resectable Gastric Cancer

TPS4141 Background: Optimal management of patients with resectable gastric cancer remains unknown. Since the INT0116 and MAGIC trials, there are 2 standards of care for adjuvant therapy: postoperative chemoradiotherapy (CRT) and perioperative ECF chemotherapy. The important question arising from these studies is whether CRT is superior to chemotherapy alone as adjuvant therapy. This randomized phase II/III trial will compare CRT to chemotherapy alone in the preoperative setting. Methods: Patients with resectable adenocarcinoma of the stomach or gastroesophageal junction will be randomized to receive either preoperative chemotherapy alone (ECFx3 as per MAGIC regimen) or preoperative CRT (ECFx2 followed by 45Gy of radiation with concurrent 5-FU). Following surgery, both groups will receive 3 further cycles of ECF. The trial is being conducted in two Parts; Part I (phase II component) will recruit 120 patients with the aim of demonstrating sufficient efficacy and safety of preoperative CRT, as well as trial feasibility. Part II (phase III component) will recruit a further 632 patients to provide a total of 752. The primary endpoint for Part I is pathological complete response rate, and for Part 2 it is overall survival. The trial includes formal quality of life and biological sub-studies. In addition, the trial incorporates a rigorous quality assurance program that includes real time central review of radiotherapy plans and central review of surgical technique. Current status: This study is an international, intergroup trial led by the Australasian Gastro-Intestinal Trials Group (AGITG), in collaboration with the Trans-Tasman Radiation Oncology Group (TROG), European Organisation for Research and Treatment of Cancer (EORTC) and the NCIC Clinical Trials Group. To date, 36 patients have been recruited from 20 sites in Australia and New Zealand; European and Canadian sites will commence recruitment in 2012.

scholarly journals Postoperative adjuvant therapy for resectable gastric cancer

1994 ◽  
Vol 3 (2) ◽  
pp. 121-125,72
Author(s):  
Kyoji Ogoshi ◽  
Yasuo Kajiura ◽  
Kenji Nakamura ◽  
Yasuo Miyaji ◽  
Kunihiro Iwata ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Therapy ◽  
Postoperative Adjuvant Therapy ◽  
Resectable Gastric Cancer

Adjuvant therapy in resectable gastric cancer—the CRITICS trial – Authors' reply

2018 ◽  
Vol 19 (7) ◽  
pp. e331
Author(s):  
Annemieke Cats ◽  
Karolina Sikorska ◽  
Marcel Verheij
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Therapy ◽  
Resectable Gastric Cancer
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