Recurrence patterns after radical gastrectomy for gastric cancer: Prognostic factors and implications for postoperative adjuvant therapy

2002 ◽  
Vol 9 (4) ◽  
pp. 394-400 ◽  
Author(s):  
Roderich E. Schwarz ◽  
Kathryn Zagala-Nevarez
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Adjuvant Therapy ◽  
Radical Gastrectomy ◽  
Postoperative Adjuvant Therapy ◽  
Recurrence Patterns

Alteration of recurrence patterns and prognostic factors by adjuvant S-1 monotherapy in patients with stage II/III gastric cancer.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 90-90
Author(s):  
Mitsuro Kanda ◽  
Daisuke Kobayashi ◽  
Chie Tanaka ◽  
Naoki Iwata ◽  
Suguru Yamada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Tumor Size ◽  
Propensity Score Analysis ◽  
Treatment Options ◽  
Stage Ii ◽  
Significant Prognostic Factor ◽  
Initial Recurrence ◽  
Macroscopic Tumor ◽  
Recurrence Patterns

90 Background: Survival benefit of adjuvant S-1 monotherapy among East Asian patients with stage II/III gastric cancer (GC) has been demonstrated by the ACTS-GC trial. Little is known about the changes in prognostic factors and recurrence patterns after it has become widespread as a standard of care. Methods: We enrolled 171 patients with stage II/III GC, 92 patients who underwent gastrectomy alone, and 79 patients treated with S-1 adjuvant. To balance more strictly the essential variables including stage of progression, we conducted propensity score analysis and 70 pairs of patients were generated from each group. Prognostic factors were compared between the groups and initial recurrence patterns were investigated to explore reasons for the change. Results: In concordance with the previous phase 3 trial, overall and recurrence-free survival were better for the S-1 adjuvant group. In the surgery alone group, carcinoembryonic antigen > 5 ng/mL, total gastrectomy, vessel invasion, pT4, and stage 3 were identified as significant prognostic factors. In striking contrast, macroscopic tumor size > 50 mm was the only significant prognostic factor for the S-1 adjuvant group. The lower overall recurrence rate of the S-1 adjuvant group was attributable mainly to a significant decrease of peritoneal recurrence. Conclusions: Prognostic factors changed substantially after implementation of S-1 adjuvant treatment. Macroscopic tumor size should be considered for patient stratification and selection of treatment options for patients with stage II/III GC.

scholarly journals Three-Tier Prognostic Index in Young Adults With Advanced Gastric Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Guang-Liang Chen ◽  
Yan Huang ◽  
Wen Zhang ◽  
Xu Pan ◽  
Wan-Jing Feng ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Young Adults ◽  
Prognostic Factors ◽  
Advanced Gastric Cancer ◽  
Prognostic Index ◽  
Risk Groups ◽  
Radical Gastrectomy ◽  
Cox Regression Analysis ◽  
Poor Risk ◽  
Number Of Patients

PurposeTo characterize clinical features and identify baseline prognostic factors for survival in young adults with advanced gastric cancer (YAAGC).Materials and MethodsA total of 220 young inpatients (age less than or equal to 40 years) with an initial diagnosis of advanced gastric cancer were retrospectively enrolled in this study.ResultsOf a consecutive cohort of 220 patients with YAAGC, the median overall survival (OS) time was 16.3 months. One-year survival rate was 43.6% (95% CI: 36.5 to 50.7). In this cohort, a female (71.4%, n = 157) predominance and a number of patients with poorly differentiated tumors (95.9%, n = 211) were observed. In the univariate analysis, OS was significantly associated with neutrophil–lymphocyte ratio (NLR) (≥3.12), hypoproteinemia (<40 g/L), presence of peritoneal or bone metastases, and previous gastrectomy of primary tumor or radical gastrectomy. In multivariate Cox regression analysis, hypoproteinemia [hazard ratio (HR) 1.522, 95% CI 1.085 to 2.137, p = 0.015] and high NLR level (HR 1.446, 95% CI 1.022 to 2.047, p = 0.021) were two independent poor prognostic factors, while previous radical gastrectomy was associated with a favorable OS (HR 0.345, 95% CI 0.205 to 0.583, p = 0.000). A three-tier prognostic index was constructed dividing patients into good-, intermediate-, or poor-risk groups. Median OS for good-, intermediate-, and poor-risk groups was 36.43, 17.87, and 11.27 months, respectively.ConclusionsThree prognostic factors were identified, and a three-tier prognostic index was devised. The reported prognostic index may aid clinical decision-making, patient risk stratification, and planning of future clinical studies on YAAGC.

Postoperative adjuvant therapy of rectal cancer: An analysis of disease control, survival, and prognostic factors

1989 ◽  
Vol 17 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Steven E. Schild ◽  
James A. Martenson ◽  
Leonard L. Gunderson ◽  
Duane M. Ilstrup ◽  
Kathryn K. Berg ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Prognostic Factors ◽  
Adjuvant Therapy ◽  
Disease Control ◽  
Postoperative Adjuvant Therapy ◽  
Control Survival

Selecting a specific pre- or postoperative adjuvant therapy for individual patients with operable gastric cancer

2006 ◽  
Vol 6 (6) ◽  
pp. 931-939 ◽  
Author(s):  
Evangelos Briasoulis ◽  
Theodore Liakakos ◽  
Lefkothea Dova ◽  
Michael Fatouros ◽  
Pericles Tsekeris ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Therapy ◽  
Postoperative Adjuvant Therapy

scholarly journals Postoperative adjuvant therapy for resectable gastric cancer

1994 ◽  
Vol 3 (2) ◽  
pp. 121-125,72
Author(s):  
Kyoji Ogoshi ◽  
Yasuo Kajiura ◽  
Kenji Nakamura ◽  
Yasuo Miyaji ◽  
Kunihiro Iwata ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adjuvant Therapy ◽  
Postoperative Adjuvant Therapy ◽  
Resectable Gastric Cancer
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