scholarly journals An assessment of extensive intraductal component as a risk factor for local recurrence after breast-conserving therapy

1990 ◽  
Vol 61 (6) ◽  
pp. 873-876 ◽  
Author(s):  
J Jacquemier ◽  
J-M Kurtz ◽  
R Amalric ◽  
H Brandone ◽  
Y Ayme ◽  
...  
Keyword(s):  
Risk Factor ◽  
Local Recurrence ◽  
Breast Conserving Therapy ◽  
Extensive Intraductal Component ◽  
Intraductal Component

Differences in Risk Factors for Local and Distant Recurrence After Breast-Conserving Therapy or Mastectomy for Stage I and II Breast Cancer: Pooled Results of Two Large European Randomized Trials

2001 ◽  
Vol 19 (6) ◽  
pp. 1688-1697 ◽  
Author(s):  
Adri C. Voogd ◽  
Maja Nielsen ◽  
Johannes L. Peterse ◽  
Mogens Blichert-Toft ◽  
Harry Bartelink ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Vascular Invasion ◽  
Breast Conservation ◽  
Breast Conserving Therapy ◽  
Distant Recurrence ◽  
Extensive Intraductal Component ◽  
Distant Disease ◽  
Increased Risk ◽  
Intraductal Component

PURPOSE: Risk factors for local and distant recurrence after breast-conserving therapy and mastectomy were compared to define guidelines for the decision making between both treatments. PATIENTS AND METHODS: The data of two randomized clinical trials for stage I and II breast cancer patients were pooled. The total number of patients in the study was 1,772, of whom 879 underwent breast conservation, and 893, modified radical mastectomy. Representative slides of the primary tumor were available for histopathologic review in 1,610 cases (91%). RESULTS: There were 79 patients with local recurrence after breast-conservation and 80 after mastectomy, the 10-year rates being 10% (95% confidence interval [CI], 8% to 13%) and 9% (95% CI, 7% to 12%), respectively. Age no more than 35 years (compared with age >60: hazard ratio [HR], 9.24; 95% CI, 3.74 to 22.81) and an extensive intraductal component (HR, 2.52; 95% CI, 1.26 to 5.00) were significantly associated with an increased risk of local recurrence after breast-conserving therapy. Vascular invasion was predictive of the risk of local recurrence, irrespective of the type of primary treatment (P < .01). Tumor size, nodal status, high histologic grade, and vascular invasion were all highly significant predictors of distant disease after breast-conserving therapy and mastectomy (P < .01). Age no more than 35 years and microscopic involvement of the excision margin were additional independent predictors of distant disease after breast-conserving therapy (P < .01). CONCLUSION: Age no more than 35 years and the presence of an extensive intraductal component are associated with an increased risk of local recurrence after breast-conserving therapy. Vascular invasion causes a higher risk of local recurrence after mastectomy as well as after breast-conserving therapy and should therefore not be used for deciding between the two treatments.

High Local Recurrence Risk After Breast-Conserving Therapy in Node-Negative Premenopausal Breast Cancer Patients Is Greatly Reduced by One Course of Perioperative Chemotherapy: A European Organization for Research and Treatment of Cancer Breast Cancer Cooperative Group Study

2000 ◽  
Vol 18 (5) ◽  
pp. 1075-1075 ◽  
Author(s):  
Paula H. M. Elkhuizen ◽  
Henk-Jan van Slooten ◽  
Pieter C. Clahsen ◽  
Jo Hermans ◽  
Cornelis J. H. van de Velde ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Local Recurrence ◽  
Breast Conserving Therapy ◽  
Perioperative Chemotherapy ◽  
Breast Cancer Patients ◽  
European Organization ◽  
Node Negative ◽  
Node Negative Breast Cancer

PURPOSE: Patients with invasive breast cancer may develop a local recurrence (LR) after breast-conserving therapy (BCT). Younger age has been found to be an independent risk factor for LR. Within a group of premenopausal node-negative breast cancer patients, we studied risk factors for LR and the effect of perioperative chemotherapy (PeCT) on LR. PATIENTS AND METHODS: The European Organization for Research and Treatment of Cancer (EORTC) conducted a randomized trial (EORTC 10854) to compare surgery followed by one course of PeCT (fluorouracil, doxorubicin, and cyclophosphamide) with surgery alone. From patients treated on this trial, we selected premenopausal patients with node-negative breast cancer who were treated with BCT to examine whether histologic characteristics and the expression of various proteins (estrogen receptor, progesterone receptor, p53, Ki-67, bcl-2, CD31, c-erbB-2/neu) are risk factors for subsequent LR. Also, the effect of one course of PeCT on the LR risk (LRR) was studied. RESULTS: Using multivariate analysis, age younger than 43 years (relative risk [RR], 2.75; 95% confidence interval [CI], 1.46 to 5.18; P = .002), multifocal growth (RR, 3.34; 95% CI, 1.27 to 8.77; P = .014), and elevated levels of p53 (RR, 2.14; 95% CI, 1.13 to 4.05; P = .02) were associated with higher LRR. Also, PeCT was found to reduce LRR by more than 50% (RR, 0.47; 95% CI, 0.25 to 0.86; P = .02). Patients younger than 43 years who received PeCT achieved similar LR rates as those of patients younger than 43 years who were treated with BCT alone. CONCLUSION: In premenopausal node-negative patients, age younger than 43 years is the most important risk factor for LR after BCT; this risk is greatly reduced by one course of PeCT. The main reason for administering systemic adjuvant treatment is to improve overall survival. The important reduction of LR after BCT is an additional reason for considering systemic treatment in young node-negative patients with breast cancer.

Family history of breast cancer and local recurrence after breast conserving therapy

1998 ◽  
Vol 34 ◽  
pp. S12
Author(s):  
C.T.M. Brekelmans ◽  
A.C. Voogd ◽  
G. Botke ◽  
A.N. van Geel ◽  
P. Rodrigus ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Family History ◽  
Local Recurrence ◽  
Breast Conserving Therapy ◽  
History Of

Risk factors for local recurrence after breast-conserving therapy

1999 ◽  
Vol 4 (4) ◽  
pp. 230-235
Author(s):  
E. Shin ◽  
Yuichi Takatsuka ◽  
Yasuhiko Okamura ◽  
Tetsuro Kobayashi ◽  
Isamu Nishisho ◽  
...  
Keyword(s):  
Risk Factors ◽  
Local Recurrence ◽  
Breast Conserving Therapy

scholarly journals Risk Factors of Local Recurrence after Breast Conserving Therapy in Invasive Breast Cancer

2009 ◽  
Vol 12 (4) ◽  
pp. 302 ◽  
Author(s):  
On Vox Yi ◽  
Jong Won Lee ◽  
Hee Jung Kim ◽  
Woo Sung Lim ◽  
Eun Hwa Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Local Recurrence ◽  
Invasive Breast Cancer ◽  
Breast Conserving Therapy
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