Risk factors for local recurrence after breast-conserving therapy

1999 ◽  
Vol 4 (4) ◽  
pp. 230-235
Author(s):  
E. Shin ◽  
Yuichi Takatsuka ◽  
Yasuhiko Okamura ◽  
Tetsuro Kobayashi ◽  
Isamu Nishisho ◽  
...  
Keyword(s):  
Risk Factors ◽  
Local Recurrence ◽  
Breast Conserving Therapy

scholarly journals Risk Factors of Local Recurrence after Breast Conserving Therapy in Invasive Breast Cancer

2009 ◽  
Vol 12 (4) ◽  
pp. 302 ◽  
Author(s):  
On Vox Yi ◽  
Jong Won Lee ◽  
Hee Jung Kim ◽  
Woo Sung Lim ◽  
Eun Hwa Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Local Recurrence ◽  
Invasive Breast Cancer ◽  
Breast Conserving Therapy

Local Recurrence (LR) after Breast Conserving Therapy (BCT); risk factors predicting for subsequent distant metastasis

1999 ◽  
Vol 35 ◽  
pp. S88-S89
Author(s):  
P.H.M. Elkhuizen ◽  
J. Hermans ◽  
J.W.H. Leer ◽  
L.C.J.M. van den Broek ◽  
M.J. van de Vijver
Keyword(s):  
Risk Factors ◽  
Local Recurrence ◽  
Distant Metastasis ◽  
Breast Conserving Therapy

PP-3-23 risk factors of local recurrence after breast conserving therapy

1996 ◽  
Vol 32 ◽  
pp. 24
Author(s):  
P.H.M. Elkhuizen ◽  
J.W.H. Leer ◽  
G.J. Fleuren ◽  
J.C. van Houwelingen ◽  
J.M.H. Hermans ◽  
...  
Keyword(s):  
Risk Factors ◽  
Local Recurrence ◽  
Breast Conserving Therapy

High Local Recurrence Risk After Breast-Conserving Therapy in Node-Negative Premenopausal Breast Cancer Patients Is Greatly Reduced by One Course of Perioperative Chemotherapy: A European Organization for Research and Treatment of Cancer Breast Cancer Cooperative Group Study

2000 ◽  
Vol 18 (5) ◽  
pp. 1075-1075 ◽  
Author(s):  
Paula H. M. Elkhuizen ◽  
Henk-Jan van Slooten ◽  
Pieter C. Clahsen ◽  
Jo Hermans ◽  
Cornelis J. H. van de Velde ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Risk Factor ◽  
Local Recurrence ◽  
Breast Conserving Therapy ◽  
Perioperative Chemotherapy ◽  
Breast Cancer Patients ◽  
European Organization ◽  
Node Negative ◽  
Node Negative Breast Cancer

PURPOSE: Patients with invasive breast cancer may develop a local recurrence (LR) after breast-conserving therapy (BCT). Younger age has been found to be an independent risk factor for LR. Within a group of premenopausal node-negative breast cancer patients, we studied risk factors for LR and the effect of perioperative chemotherapy (PeCT) on LR. PATIENTS AND METHODS: The European Organization for Research and Treatment of Cancer (EORTC) conducted a randomized trial (EORTC 10854) to compare surgery followed by one course of PeCT (fluorouracil, doxorubicin, and cyclophosphamide) with surgery alone. From patients treated on this trial, we selected premenopausal patients with node-negative breast cancer who were treated with BCT to examine whether histologic characteristics and the expression of various proteins (estrogen receptor, progesterone receptor, p53, Ki-67, bcl-2, CD31, c-erbB-2/neu) are risk factors for subsequent LR. Also, the effect of one course of PeCT on the LR risk (LRR) was studied. RESULTS: Using multivariate analysis, age younger than 43 years (relative risk [RR], 2.75; 95% confidence interval [CI], 1.46 to 5.18; P = .002), multifocal growth (RR, 3.34; 95% CI, 1.27 to 8.77; P = .014), and elevated levels of p53 (RR, 2.14; 95% CI, 1.13 to 4.05; P = .02) were associated with higher LRR. Also, PeCT was found to reduce LRR by more than 50% (RR, 0.47; 95% CI, 0.25 to 0.86; P = .02). Patients younger than 43 years who received PeCT achieved similar LR rates as those of patients younger than 43 years who were treated with BCT alone. CONCLUSION: In premenopausal node-negative patients, age younger than 43 years is the most important risk factor for LR after BCT; this risk is greatly reduced by one course of PeCT. The main reason for administering systemic adjuvant treatment is to improve overall survival. The important reduction of LR after BCT is an additional reason for considering systemic treatment in young node-negative patients with breast cancer.

scholarly journals The risk factors of local recurrence and distant metastasis on pT1/T2N0 mid-low rectal cancer after total mesorectal excision

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
I-Li Lai ◽  
Jeng-Fu You ◽  
Yih-Jong Chern ◽  
Wen-Sy Tsai ◽  
Jy-Ming Chiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rectal Cancer ◽  
Local Recurrence ◽  
Distant Metastasis ◽  
Resection Margin ◽  
Radical Resection ◽  
Hazard Ratio ◽  
Low Rectal Cancer ◽  
Distal Resection Margin ◽  
Lymph Node Yield

Abstract Background Radical resection is associated with good prognosis among patients with cT1/T2Nx rectal cancer. However, still some of the patients experienced cancer recurrence following radical resection. This study tried to identify the postoperative risk factors of local recurrence and distant metastasis separately. Methods This retrospective, single-center study comprised of 279 consecutive patients from Linkou branch of Chang Gung Memorial Hospital in 2005–2016 with rectal adenocarcinoma, pT1/T2N0M0 at distance from anal verge ≤ 8cm, who received curative radical resection. Results The study included 279 patients with pT1/pT2N0 mid-low rectal cancer with median follow-up of 73.5 months. Nineteen (6.8%) patients had disease recurrence in total. Nine (3.2%) of them had local recurrence, and fourteen (5.0%) of them had distant metastasis. Distal resection margin < 0.9 (cm) (hazard ratio = 4.9, p = 0.050) was the risk factor of local recurrence. Preoperative carcinoembryonic antigen (CEA) ≥ 5 ng/mL (hazard ratio = 9.3, p = 0.0003), lymph node yield (LNY) < 14 (hazard ratio = 5.0, p = 0.006), and distal resection margin < 1.4cm (hazard ratio = 4.0, p = 0.035) were the risk factors of distant metastasis. Conclusion For patients with pT1/pT2N0 mid-low rectal cancer, current multidisciplinary treatment brings acceptable survival outcome. Insufficient distal resection margin attracted the awareness of risk factors for local recurrence and distant metastasis as a foundation for future research.

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