scholarly journals Relationship of total serum sialic acid to sialylglycoprotein acute-phase reactants in malignant melanoma

1980 ◽  
Vol 41 (5) ◽  
pp. 745-750 ◽  
Author(s):  
H K Silver ◽  
K A Karim ◽  
F A Salinas
Keyword(s):  
Sialic Acid ◽  
Malignant Melanoma ◽  
Acute Phase ◽  
Total Serum ◽  
Acute Phase Reactants ◽  
Serum Sialic Acid ◽  
Relationship Of

scholarly journals Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Alejandro Sanchez ◽  
Colleen Azen ◽  
Brenda Jones ◽  
Stan Louie ◽  
Fred Sattler
Keyword(s):  
Acute Phase ◽  
Muscle Wasting ◽  
Cell Mass ◽  
Fat Free Mass ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Low Levels ◽  
Beta 2 Microglobulin ◽  
Relationship Of

Background. Tuberculosis causes inflammation and muscle wasting. We investigated how attenuation of inflammation relates to repletion of body composition during treatment in an underserved population.Design. Twenty-four patients (23 to 79 years old) with pulmonary tuberculosis and inflammation (pretreatment albumin  g/dL, C-reactive protein [CRP]  μg/dL, and beta-2-microglobulin  μg/L) were evaluated and had BIA over 24 weeks.Results. Weight increased by  kg (5.5%; ) at week 4 and by  kg (15.6%; ) at week 24. Repletion of body mass was primarily fat, which increased by  kg at week 4 and  kg at week 24 ( and versus baseline). Fat-free mass (FFM), body cell mass (BCM), and phase angle did not increase until study week 8. Albumin rose to  g/dL by week 4 () and slowly increased thereafter. CRP levels declined by~50% at each interval visit.Conclusions. During the initial treatment, acute phase reactants returned towards normal. The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation.

Serum sialic acid and acute phase proteins in type 1 and type 2 diabetes mellitus

1993 ◽  
Vol 219 (1-2) ◽  
pp. 131-138 ◽  
Author(s):  
Martin A. Crook ◽  
Peter Tutt ◽  
Helen Simpson ◽  
John C. Pickup
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Sialic Acid ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Serum Sialic Acid

Serum sialic acid concentration in patients with hypertriglyceridaemia showing the Frederickson's IIB phenotype

1992 ◽  
Vol 83 (5) ◽  
pp. 593-595 ◽  
Author(s):  
M. Crook ◽  
P. Tutt
Keyword(s):  
Cardiovascular Risk ◽  
Sialic Acid ◽  
Normal Control ◽  
Acid Concentration ◽  
Serum Lipid ◽  
Total Serum ◽  
Control Group ◽  
Total Sialic Acid ◽  
Triacylglycerol Concentration ◽  
Serum Sialic Acid

1. Serum total sialic acid concentration, recently shown to be a cardiovascular risk factor, and also serum lipid-associated sialic acid concentration were measured in 15 patients with hypertriglyceridaemia (fasting serum triacylglycerol concentration > 2.3 mmol/l) showing a Frederickson's type IIB phenotype, 15 patients with hypercholesterolaemia showing a IIA phenotype and 15 age- and sex-matched normal control subjects. 2. Total serum sialic acid concentration was significantly raised in the hypertriglyceridaemic group (84.9 ± 21.5 versus 64.9 ± 20.8 mg/dl, P<0.03, Mann—Whitney U-test) compared with the normal control group, as was serum lipid-associated sialic acid concentration (23.0 ± 4.3 versus 12.0 ± 3.2 mg/dl, respectively, P<0.001, Mann—Whitney U-test). 3. Serum total sialic acid concentration was also significantly elevated in the hypertriglyceridaemic group as compared with the IIA phenotype hypercholesterolaemic group (84.9 ± 21.5 versus 58.4 ± 11.7 mg/dl, P<0.03, Mann—Whitney U-test), as was serum lipid-associated sialic acid concentration (23.0 ± 4.3 versus 14.9 ± 4.7 mg/dl, P<0.001, Mann—Whitney U-test). 4. We suggest that serum concentrations of both total sialic acid and lipid-associated sialic acid may be useful markers of cardiovascular risk which could, in part, be related to hypertriglyceridaemia.

scholarly journals SERUM AND TISSUE MUCOPROTEINS AND SIALIC ACID IN THYROID DISEASES

2008 ◽  
Vol 15 (03) ◽  
pp. 309-316
Author(s):  
ZARFAR IQBAL ◽  
TASNEEM ZAFAR
Keyword(s):  
Sialic Acid ◽  
Correlation Coefficient ◽  
Inverse Relationship ◽  
Thyroid Tissue ◽  
Normal Subjects ◽  
Thyroid Diseases ◽  
Pathological State ◽  
Serum Sialic Acid ◽  
Toxic Goiter ◽  
Relationship Of

. Objective: To find the correlation coefficient of serum mucoproteins and sialic acid to thyroid tissuein thyroid diseases. Study Design: The study was carried out at J.P.M.C, Karachi. Materials and Methods: A total oftwenty four thyroid patients and twenty normal subjects were studied. The cases were divided into non toxic goiterfourteen, and toxic goiter ten on the basis of clinical and physical examination, thyroid scanning and hormone analysis.Thyroid hormones were estimated in serum. Mucoproteins and sialic acid were estimated in serum as well as in thyroidtissue. Results: Estimations of thyroid hormones and thyroxine binding globulin (T.B.G.) are useful clinically to evaluatethe functions status and diagnosis of different thyroid disorders. Thyroid tissue is mainly composed of glycoprotein,thyroglobulin, and different studies showed that serum glycoprotein fractions varied in different thyroid diseases.Si 4gnificantly increased levels of T were observed in toxic goiter group. The levels of TBG was significantly increased4in non toxic goiter, toxic goiter patients while T /TBG ratio was significantly decreased in non toxic goiter. Coefficientcorrelation ( r) of serum to tissue mucoproteins shows an inverse relationship in non toxic goiter and toxic goiter patients.In non toxic goiter and toxic goiter patients the serum sialic acid levels to tissue sialic acid levels also shows an inverserelationship. Conclusion: Correlation coefficient analysis showed an inverse relationship of serum mucoproteins andsialic acid to thyroid tissue. It signifies that carbohydrate moieties are increased in the blood when the tissue arehyperactive and in the pathological state. It further concludes that thyrotoxic state might be converted into nodular formeven into cancerous form later on.

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