Serum sialic acid concentration in patients with hypertriglyceridaemia showing the Frederickson's IIB phenotype

1992 ◽  
Vol 83 (5) ◽  
pp. 593-595 ◽  
Author(s):  
M. Crook ◽  
P. Tutt
Keyword(s):  
Cardiovascular Risk ◽  
Sialic Acid ◽  
Normal Control ◽  
Acid Concentration ◽  
Serum Lipid ◽  
Total Serum ◽  
Control Group ◽  
Total Sialic Acid ◽  
Triacylglycerol Concentration ◽  
Serum Sialic Acid

1. Serum total sialic acid concentration, recently shown to be a cardiovascular risk factor, and also serum lipid-associated sialic acid concentration were measured in 15 patients with hypertriglyceridaemia (fasting serum triacylglycerol concentration > 2.3 mmol/l) showing a Frederickson's type IIB phenotype, 15 patients with hypercholesterolaemia showing a IIA phenotype and 15 age- and sex-matched normal control subjects. 2. Total serum sialic acid concentration was significantly raised in the hypertriglyceridaemic group (84.9 ± 21.5 versus 64.9 ± 20.8 mg/dl, P<0.03, Mann—Whitney U-test) compared with the normal control group, as was serum lipid-associated sialic acid concentration (23.0 ± 4.3 versus 12.0 ± 3.2 mg/dl, respectively, P<0.001, Mann—Whitney U-test). 3. Serum total sialic acid concentration was also significantly elevated in the hypertriglyceridaemic group as compared with the IIA phenotype hypercholesterolaemic group (84.9 ± 21.5 versus 58.4 ± 11.7 mg/dl, P<0.03, Mann—Whitney U-test), as was serum lipid-associated sialic acid concentration (23.0 ± 4.3 versus 14.9 ± 4.7 mg/dl, P<0.001, Mann—Whitney U-test). 4. We suggest that serum concentrations of both total sialic acid and lipid-associated sialic acid may be useful markers of cardiovascular risk which could, in part, be related to hypertriglyceridaemia.

Relationship between serum sialic acid concentration and diabetic retinopathy in Egyptian patients with type 2 diabetes mellitus

2018 ◽  
Vol 35 (2) ◽  
pp. 257
Author(s):  
AhmedE Mansour ◽  
MohamedS El-Sayed ◽  
Ayman El Badawy ◽  
RashaO Abdelmoneim ◽  
MedhatEl-Moneim Khalil ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Sialic Acid ◽  
Acid Concentration ◽  
Serum Sialic Acid ◽  
Egyptian Patients

Serum Sialic Acid Concentration and Content in ApoB-Containing Lipoproteins in Liver Diseases

2016 ◽  
Vol 62 (06/2016) ◽  
Author(s):  
Monika Gudowska ◽  
Ewa Gruszewska ◽  
Bogdan Cylwik ◽  
Anatol Panasiuk ◽  
Robert Filisiak ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Acid Concentration ◽  
Liver Diseases ◽  
Serum Sialic Acid

scholarly journals Tumours of the central nervous system and serum sialic acid concentration in men and women

1993 ◽  
Vol 68 (2) ◽  
pp. 425-427 ◽  
Author(s):  
O Gatchev ◽  
L Råstam ◽  
G Lindberg ◽  
B Gullberg ◽  
GA Eklund ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Sialic Acid ◽  
Acid Concentration ◽  
Men And Women ◽  
Serum Sialic Acid ◽  
The Central Nervous System

scholarly journals Serum Sialic Acid Concentration in Diabetic Subjects with Special Reference to Lipid Concentration

1987 ◽  
Vol 15 (5) ◽  
pp. 1193-1196
Author(s):  
Yasuko ICHIBA ◽  
Yasuhiro ORIBE ◽  
Hiroshi KUWAHARA ◽  
Ryosaburo TAKAKI
Keyword(s):  
Sialic Acid ◽  
Special Reference ◽  
Acid Concentration ◽  
Lipid Concentration ◽  
Serum Sialic Acid

CHANGES IN PLATELET SURVIVAL AND SIALIC ACID CONCENTRATION IN PLASMODIUM BERGEI INFECTED RATS

1987 ◽  
Author(s):  
E M Essien ◽  
A L Inyang
Keyword(s):  
Sialic Acid ◽  
Acid Concentration ◽  
Wistar Rats ◽  
Severe Thrombocytopenia ◽  
Control Value ◽  
Total Sialic Acid ◽  
Platelet Survival ◽  
Immune Mediated ◽  
The Difference ◽  
Survival Studies

Reduced circulating platelet count sometimes to thrombocytopenic levels in man and normally severe thrombocytopenia in animals are well known features of acute Plasmodium falciparum or experimental P. bergei infections in these respective organisms. Suggested mechanism(s), disseminated intravascular coagulation or immune mediated mechanism, thought to be involved in these observations are disputed. Shortened platelet survival has been reported in man.We now present data on platelet survival and total platelet sialic acid concentration in P. bergei-infected Wistar rats. A total of 52 rats were used. For the platelet survival studies each of the 8 suckling test animals was infected by intraperi-toneal route with mouse-passaged P. bergei 4-5 days before inaction of Cr-labelled homologous rat platelets (50 μCi Na51 CrC4/rat) the platelets being obtained from adult Wistarrats. Blood samples were then collected 2 hr after the injection (zero hr sample) and subsequently at 17.0, 42.5 and 66 hr s.Platelet recovery and survival curves were determined on these samples. It was found dat fewer platelets (as % recovery) were obtained from each infected rat sample compared with control, the difference was significant in the 42.5 and 66 hr samples: 7.9 ± 8.1 (test) vs 41.4 ± 15.2% (C) for 42.5 hr and 2.8 ±4.1 (t) vs 26.8 ± 6.2% (C) for the 66 hr samples (p < 0.005 for each). For sialic acid determinations, 40 suckling Wistar rats (30 test, 10 control) were treated as for survival studies.At identical periods, blood was collected, washed platelets obtained, lysed and protein and total sialic acid determined by Lowry (1951) and Aminoff (1961) methods respectively. Total sialic acid of 7.02 ± 4.21 nM/mg protein at 42.5 hrs and 4.8 ± 2.14 at 66 hrs were significantly less than control value of 11.43 nm/mg protein and also showed a negative correlation (r = -0.95) with % parasitaemia.It is concluded that P. bergei infection causes a reduction in total platelet sialic acid with resultant significant shortening of the platelet life span.

Low vitamin B12 level in relation to trace element, total sialic acid and antioxidant enzymes in children with vitamin B12 deficiency anemia

2021 ◽  
pp. 1-10
Author(s):  
Isa Kiran ◽  
Suat Ekin ◽  
Özge Vural
Keyword(s):  
Sialic Acid ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Deficiency Anemia ◽  
Control Group ◽  
Vitamin B ◽  
Cobalt Chromium ◽  
Control Subjects ◽  
Total Sialic Acid ◽  
The Mean

Abstract. In this study, children with vitamin B12 deficiency anemia (V-B12DA) and control subjects were evaluated for erythrocyte glutathione peroxidase, catalase and superoxide dismutase enzyme activities, glutathione, malondialdehyde, serum total sialic acid, total antioxidant status, cobalt, chromium, copper, selenium, vanadium, zinc, iron, lead, magnesium, calcium, sodium, potassium, chloride, phosphorus levels, and the associations of these variables were assessed. The study included 50 children with V-B12DA and 50 control subjects. It was found that the V-B12DA group was significantly lower than the control group, with regard to the mean±the standard error of the mean levels of cobalt (0.089±0.009; 0.058±0.0063 μmol/L, p<0.01), selenium (2.19±0.087; 1.88±0.057 μmol/L, p<0.01), vanadium (1.31±0.053; 1.18±0.035 μmol/L, p<0.05), magnesium (3.02±0.15; 2.73±0.068 μmol/L, p<0.05), zinc (50.76±1.96; 42.23± 1.53 μmol/L, p<0.001), and vitamin B12 (427.20±21.45; 157.08±3.96 pg/mL, p<0.001). Moreover, a significant elevation in total sialic acid (1.44±0.050; 1.61±0.043 mmol/L, p<0.01), and mean corpuscular volume (MCV) (75.37±0.95; 79.91±1.14 fL, p<0.01). It was observed that in the V-B12DA, significantly linear correlations were observed between cobalt – vitamin B12 (r=0.334; p=0.025), vanadium – MCV (r=0.315; p=0.017), vitamin B12 – MCV (r=−0.297; p=0.026). The findings of the study indicated that the levels of cobalt, vanadium significantly associated with traditional vitamin B12-deficiency parameters. Vitamin B12 and MCV should be measured together with cobalt, vanadium for monitoring the vitamin B12 deficiency anemia.

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