scholarly journals Lack of effect of immunotherapy with BCG and Corynebacterium parvum on hepatic drug hydroxylation in man

1979 ◽  
Vol 39 (4) ◽  
pp. 441-444 ◽  
Author(s):  
H H Wan ◽  
N Thatcher ◽  
P W Mullen ◽  
G N Smith ◽  
P M Wilkinson
Keyword(s):  
Hepatic Drug ◽  
Corynebacterium Parvum ◽  
Drug Hydroxylation

Inhibition of hepatic drug metabolism in the rat after Corynebacterium parvum treatment

1983 ◽  
Vol 32 (7) ◽  
pp. 1275-1280 ◽  
Author(s):  
David Farquhar ◽  
John A. Benvenuto ◽  
Nancy Kuttesch ◽  
Ti Li Loo
Keyword(s):  
Drug Metabolism ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
Corynebacterium Parvum

Effect of diphenylhydantoin on hepatic drug hydroxylation

1974 ◽  
Vol 7 (4) ◽  
pp. 281-285 ◽  
Author(s):  
F. Petruch ◽  
R. V. A. Sch�ppel ◽  
G. Steinhilber
Keyword(s):  
Hepatic Drug ◽  
Drug Hydroxylation

Stimulation of hepatic drug hydroxylation and conjugation by a cutaneously applied PCB-mixture (Clophen A 50)

1977 ◽  
Vol 18 (2) ◽  
pp. 247-251 ◽  
Author(s):  
Jukka Marniemi ◽  
Markku Nokkala ◽  
Harri Vainio ◽  
Kaarlo J.W. Hartiala
Keyword(s):  
Hepatic Drug ◽  
Drug Hydroxylation ◽  
Stimulation Of

scholarly journals Hepatic drug hydroxylation and lipid peroxidation in riboflavin-deficient rats*

1974 ◽  
Vol 140 (3) ◽  
pp. 363-368 ◽  
Author(s):  
J. M. Patel ◽  
N. R. Galdhar ◽  
S. S. Pawar
Keyword(s):  
Lipid Peroxidation ◽  
Adult Female ◽  
Adult Male ◽  
Female Rats ◽  
Hydroxylase Activity ◽  
Riboflavin Deficiency ◽  
Hepatic Drug ◽  
Drug Hydroxylation ◽  
Riboflavin Deficient

The effect of riboflavin deficiency and phenobarbital pretreatment on drug hydroxylation and lipid peroxidation was investigated. A significant decrease in aniline and acetanilide hydroxylation as well as NADPH-linked and ascorbate-induced lipid peroxidation was observed during 4- and 7-week riboflavin deficiency in both adult male and adult female rats. The drug-hydroxylation and lipid-peroxidation activities were further lowered with the increase in riboflavin deficiency. The phenobarbital pretreatment induced aniline and acetanilide hydroxylase activity even in riboflavin-deficient animals. Drug hydroxylation inhibits lipid peroxidation in both deficient and normal rats. The administration of riboflavin was followed by a significant increase in drug hydroxylation and lipid peroxidation.

New Applications of Oleanolic Acid and its Derivatives as Cardioprotective Agents: A Review of their Therapeutic Perspectives

2019 ◽  
Vol 25 (35) ◽  
pp. 3740-3750 ◽  
Author(s):  
Ning Sun ◽  
Dongli Li ◽  
Xiaoqing Chen ◽  
Panpan Wu ◽  
Yu-Jing Lu ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Liver Diseases ◽  
Therapeutic Agent ◽  
Heart Diseases ◽  
Pentacyclic Triterpenoids ◽  
Hepatic Drug ◽  
Approved Drugs ◽  
New Applications ◽  
Functional Mechanisms ◽  
Potent Therapeutic Agent

Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.

scholarly journals The effects of the new macrolide antibiotic clarithromycin on hepatic drug- $$$metabolizing enzyme in rats

1992 ◽  
Vol 58 ◽  
pp. 331
Author(s):  
Reiji Kitashiro ◽  
Norimitsu Kurata ◽  
Shinichi Kobayashi ◽  
Yuki Nishimura ◽  
Eiji Uchida ◽  
...  
Keyword(s):  
Macrolide Antibiotic ◽  
Hepatic Drug ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme
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