scholarly journals The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma

2014 ◽  
Vol 4 (7) ◽  
pp. e229-e229 ◽  
Author(s):  
A Tagde ◽  
H Singh ◽  
M H Kang ◽  
C P Reynolds
Keyword(s):  
Multiple Myeloma ◽  
Buthionine Sulfoximine ◽  
Preclinical Models ◽  
Synthesis Inhibitor ◽  
Glutathione Synthesis

Interactions of nitroglycerin and sulfhydryl-donating compounds in coronary microvessels

1994 ◽  
Vol 266 (1) ◽  
pp. H291-H297 ◽  
Author(s):  
R. M. Wheatley ◽  
S. P. Dockery ◽  
M. A. Kurz ◽  
H. S. Sayegh ◽  
D. G. Harrison
Keyword(s):  
Redox Potential ◽  
Potent Inhibitor ◽  
Buthionine Sulfoximine ◽  
Glutathione Synthesis ◽  
Endothelin 1 ◽  
Intracellular Glutathione ◽  
Enzymatic Bioconversion

Previous studies have shown the effect of nitroglycerin on coronary microvessels < 100 microns in diameter is markedly enhanced by L-cysteine. These studies were performed to examine the mechanisms responsible for this effect. Under control conditions, nitroglycerin caused potent dilations of large (> 200 microns diam) coronary microvessels while having minimal effects on small (< 100 microns diam) coronary microvessels [peak relaxations 85 +/- 4 vs. 23 +/- 3% (mean +/- SE) of endothelin-1-constricted vessels, respectively]. L-Cysteine (100 microM) and N-acetylcysteine (100 microM) markedly enhanced nitroglycerin-induced relaxations of small coronary microvessels (peak relaxation 84 +/- 6 and 87 +/- 12%, respectively) while having no effect on relaxations of vessels > 100 microns. In contrast, neither L-methionine (100 microM) nor glutathione (100 microM) enhanced nitroglycerin's vasodilation of small coronary microvessels. The effects of L-cysteine and N-acetylcysteine on the augmentation of nitroglycerin vasodilatation in smaller coronary microvessels was abolished in the presence of buthionine sulfoximine (100 microM), a potent inhibitor of intracellular glutathione synthesis. Buthionine sulfoximine had no effect on the vasodilatation produced by nitroprusside. These data demonstrate that, in smaller coronary microvessels, L-cysteine and N-acetylcysteine enhance nitroglycerin-induced vasodilatation by increasing intracellular glutathione concentrations. Intracellular glutathione, formed from either L-cysteine or N-acetylcysteine, may participate in the formation of an intermediate of nitroglycerin biotransformation or may maintain a redox potential within coronary microvessels that favors enzymatic bioconversion of nitroglycerin.

scholarly journals New Insights in Anti-Angiogenesis in Multiple Myeloma

2018 ◽  
Vol 19 (7) ◽  
pp. 2031 ◽  
Author(s):  
Domenico Ribatti ◽  
Angelo Vacca
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Plasma Cells ◽  
Recent Literature ◽  
Therapeutic Agents ◽  
Bone Marrow Microenvironment ◽  
Clinical Settings ◽  
Preclinical Models ◽  
Direct Production ◽  
Angiogenic Cytokines

Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and involves direct production of angiogenic cytokines by plasma cells and their induction within the bone marrow microenvironment. This article summarizes the more recent literature data concerning the employment of anti-angiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of multiple myeloma.

scholarly journals Inhibition of Interleukin-6 Signaling with CNTO 328 Enhances the Activity of Bortezomib in Preclinical Models of Multiple Myeloma

2007 ◽  
Vol 13 (21) ◽  
pp. 6469-6478 ◽  
Author(s):  
Peter M. Voorhees ◽  
Qing Chen ◽  
Deborah J. Kuhn ◽  
George W. Small ◽  
Sally A. Hunsucker ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Interleukin 6 ◽  
Preclinical Models
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