scholarly journals Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats

2010 ◽  
Vol 31 (8) ◽  
pp. 930-937 ◽  
Author(s):  
Ji-ye Aa ◽  
Guang-ji Wang ◽  
Hai-ping Hao ◽  
Qing Huang ◽  
Yi-hong Lu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Agents ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Stimulation of Peripheral Dopamine Receptors in Rats: A Mechanism for Novel Antihypertensive Agents

1980 ◽  
Vol 59 (s6) ◽  
pp. 291s-294s ◽  
Author(s):  
Francloise Lefegvre-Borg ◽  
Icilio Cavero
Keyword(s):  
Blood Pressure ◽  
Dopamine Receptors ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Agents ◽  
Sympathetic Ganglia ◽  
Vasomotor Tone ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Sympathetic Vasomotor Tone ◽  
Stimulation Of

1. The aim of this investigation was to provide support for the hypothesis that stimulation of peripheral dopamine receptors reduces sympathetic vasomotor tone and thus may be a mechanism for novel antihypertensive agents. 2. NN-Di-n-propyldopamine (DPDA: 0.03-0.1 mg min−1 kg−1 intra-arterially) produced sustained decreases in blood pressure measured from the cannulated tail artery in conscious spontaneously hypertensive rats. 3. This antihypertensive action of DPDA was antagonized by sulpiride but not by atropine, promethazine, propranolol or indomethacin. 4. DPDA failed to lower blood pressure in spontaneously hypertensive rats in which peripheral stores of catecholamines had been previously depleted with syrosingopine. 5. In the pithed atropine-pretreated spontaneously hypertensive rats in which the low blood pressure was elevated by electrical stimulation of the spinal cord, DPDA produced hypotensive effects which were antagonized by sulpiride. However, DPDA, in contrast to phentolamine, did not modify the blood pressure raised by an infusion of adrenaline. 6. In conclusion, the blood pressure-lowering action of DPDA is due to stimulation of dopamine receptors which decreases noradrenaline release and consequently sympathetic vasomotor tone. These receptors may be located on sympathetic ganglia or sympathetic endings innervating resistance vessels.

scholarly journals Antihypertensive effect of aqueous polyphenol extracts of Amaranthusviridis and Telfairiaoccidentalis leaves in spontaneously hypertensive rats

2018 ◽  
Vol 1 ◽  
Author(s):  
Olayinka A. Olarewaju ◽  
Adeola M. Alashi ◽  
Rotimi E Aluko
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Agents ◽  
Hypertensive Rats ◽  
Leaf Extracts ◽  
Spontaneously Hypertensive ◽  
Angiotensin I Converting Enzyme ◽  
Arterial Blood ◽  
Renin Inhibition

The antihypertensive effects of aqueous polyphenol-rich extracts of Amaranthusviridis (AV) and Telfairiaoccidentalis (TO) leaves in spontaneously hypertensive rats (SHR) were investigated. The dried vegetable leaves were extracted using 1:20 (leaves:water, w/v) ratio for 4 h at 60 °C. Results showed significantly (P < 0.05) higher polyphenol contents in TO extracts (80–88 mg gallic acid equivalents, GAE/100 mg) when compared with the AV (62–67 mg GAE/100 mg). Caffeic acid, rutin and myricetin were the main polyphenols found in the extracts. The TO extracts had significantly (P < 0.05) higher in vitro inhibition of angiotensin I-converting enzyme (ACE) activity while AV extracts had better renin inhibition. Oral administration (100 mg/kg body weight) to SHR led to significant (P < 0.05) reductions in systolic blood pressure for the AV (−39 mmHg after 8 h)and TO (−24 mmHg after 4 and 8 h).The vegetable extracts also produced significant (P < 0.05) reductions in diastolic blood pressure, mean arterial blood pressure and heart rate when compared to the untreated rats. Thus both the AV and TO leaf extracts have the potential to be used as antihypertensive agents, especially the AV, which produced persistent long-lasting effect over a 24 h period.

Sign in / Sign up

Export Citation Format

Share Document