scholarly journals Active ingredients in Chinese medicines promoting blood circulation as Na+/K+-ATPase inhibitors

2011 ◽  
Vol 32 (2) ◽  
pp. 141-151 ◽  
Author(s):  
Ronald JY Chen ◽  
Tzyy-rong Jinn ◽  
Yi-ching Chen ◽  
Tse-yu Chung ◽  
Wei-hung Yang ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Active Ingredients ◽  
Chinese Medicines ◽  
Atpase Inhibitors

The Application of High Throughput Microarrays in the Screening Active Ingredients of Traditional Chinese Medicine

2014 ◽  
Vol 998-999 ◽  
pp. 346-349
Author(s):  
Qing Shan Liu ◽  
Wei Wei Zhang ◽  
Xu Li ◽  
Shu Juan Zhuang ◽  
Xiao Ying Yin
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
High Throughput ◽  
Detection Method ◽  
Active Ingredients ◽  
Chinese Medicines ◽  
Accurate Detection ◽  
And Control ◽  
Research Tools

The accurate detection of traditional Chinese medicine is significant for diagnosis, treatment and control for disease. There is an urgent need for the development of a rapid, simple, and accurate detection method. The high throughput microarray is recommended for use in all researches including those involving rare samples and expensive reagents. Due to the complexity of Chinese medicines interference and multi-target, multi-component, the advantages that sensitivity, reproducibility, and specificity of high-throughput microarrays make it become one of the effective research tools.

Natural Products with Analgesic Effect from Herbs and Nutraceuticals Used in Traditional Chinese Medicines

2020 ◽  
Vol 20 (6) ◽  
pp. 461-483 ◽  
Author(s):  
Tian-Xing Wang ◽  
Guo-Jie Wu ◽  
Jian-Guo Jiang
Keyword(s):  
Nervous System ◽  
Clinical Symptoms ◽  
Early Gene ◽  
Traditional Chinese Medicines ◽  
Active Ingredients ◽  
Chinese Medicines ◽  
The Central Nervous System ◽  
Development And Utilization ◽  
Endogenous Analgesia ◽  
Brain Tissues

Introduction: Pain is one of the most common clinical symptoms . This review aims to describe research on herbs and their active ingredients in treating pain and provide a valuable reference for the development and utilization of analgesic traditional Chinese medicine (TCM). Materials and Methods: The literature search was performed from 1995 to October 2016, covering the relevant studies that concern the treatment of pain with TCM. Active ingredients extracted from TCM with analgesic activity are summarized and classified into six categories, including polysaccharides, saponins, alkaloids, flavonoids, terpenoids, and other constituents. Results: There are two pathways constituting the analgesic mechanisms of TCM: through the central nervous system and the peripheral nervous system. The former pathway includes increasing the content of endogenous analgesic substances like opiate peptide, cutting down the second messenger of neurotransmitter like nitric oxide (NO), reducing the content of prostaglandin E2 (PGE2) in brain tissues, blocking the central calcium channel, reducing excitatory amino acids in brain tissues, inhibiting their receptors and raising the content of the central 5-hydroxytryptamine (5-HT). The latter one usually involves the decrease in the secretion of peripheral algogenic substances, the induction of pain-sensitive substances, the accumulation of a local algogenic substance, the increase in the release of peripheral endogenous analgesia materials and the regulation of c-Fos gene (immediate early gene).

Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines

2004 ◽  
Vol 36 (12) ◽  
pp. 1575-1587 ◽  
Author(s):  
Soon Yew Tang ◽  
Matthew Whiteman ◽  
Zhao Feng Peng ◽  
Andrew Jenner ◽  
Eu Leong Yong ◽  
...  
Keyword(s):  
Traditional Chinese Medicines ◽  
Active Ingredients ◽  
Chinese Medicines

scholarly journals Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis

2021 ◽  
Vol 22 (3) ◽  
pp. 190-203
Author(s):  
Bingyu Sun ◽  
Yongqiang Liu ◽  
Danhua He ◽  
Jinke Li ◽  
Jiawei Wang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Traditional Chinese Medicines ◽  
Active Ingredients ◽  
Chinese Medicines ◽  
Induced Apoptosis

scholarly journals The Antitumor Efficacy of β-Elemene by Changing Tumor Inflammatory Environment and Tumor Microenvironment

2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
Qiang Xie ◽  
Fengzhou Li ◽  
Lei Fang ◽  
Wenzhi Liu ◽  
Chundong Gu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cancer Cells ◽  
Traditional Chinese Medicines ◽  
Active Ingredients ◽  
Antitumor Effects ◽  
Tumor Immune Escape ◽  
Chinese Medicines ◽  
Inflammatory Microenvironment ◽  
Anti Inflammatory

Inflammatory mediators and inflammatory cells in the inflammatory microenvironment promote the transformation of normal cells to cancer cells in the early stage of cancer, promote the growth and development of cancer cells, and induce tumor immune escape. The monomeric active ingredient β-elemene is extracted from the traditional Chinese medicine Curcuma wenyujin and has been proven to have good anti-inflammatory and antitumor activities in clinical applications for more than 20 years in China. Recent studies have found that this traditional Chinese medicine plays a vital role in macrophage infiltration and M2 polarization, as well as in regulating immune disorders, and it even regulates the transcription factors NF-κB and STAT3 to alter inflammation, tumorigenesis, and development. In addition, β-elemene regulates not only different inflammatory factors (such as TNF-α, IFN, TGF-β, and IL-6/10) but also oxidative stress in vivo and in vitro. The excellent anti-inflammatory and antitumor effects of β-elemene and its ability to alter the inflammatory microenvironment of tumors have been gradually elaborated. Although the study of monomeric active ingredients in traditional Chinese medicines is insufficient in terms of quality and quantity, the pharmacological effects of more active ingredients of traditional Chinese medicines will be revealed after β-elemene.

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