scholarly journals Effect of acetaminophen (paracetamol) on human osteosarcoma cell line MG63

2010 ◽  
Vol 31 (11) ◽  
pp. 1495-1499 ◽  
Author(s):  
Lourdes Díaz-Rodríguez ◽  
Olga García-Martínez ◽  
Manuel Arroyo-Morales ◽  
Belén Rubio-Ruiz ◽  
Concepción Ruiz
Keyword(s):  
Cell Line ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Human Osteosarcoma Cell Line ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cell ◽  
Osteosarcoma Cell Line Mg63

Recognition by cellular and humoral autologous immunity in a human osteosarcoma cell line

2003 ◽  
Vol 8 (4) ◽  
pp. 554-559 ◽  
Author(s):  
Yuki Nabeta ◽  
Kawaguchi Satoshi ◽  
Hiroeki Sahara ◽  
Hideyuki Ikeda ◽  
Yoshihiko Hirohashi ◽  
...  
Keyword(s):  
Cell Line ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Human Osteosarcoma Cell Line ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cell

scholarly journals Effect of Orento, a Traditional Japanese Medicine, on IL-6, IL-8 Secretion, Type 1 Collagen Production and Alkaline Phosphatase Secretion in the Human Osteosarcoma Cell Line Saos-2

Medicines ◽  
2020 ◽  
Vol 7 (10) ◽  
pp. 61
Author(s):  
Hourei Oh ◽  
Kazuya Masuno ◽  
Nobutaka Okusa ◽  
Yoshimasa Makita ◽  
Shin-ichi Fujiwara ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Cell Line ◽  
Osteosarcoma Cell Line ◽  
Osteosarcoma Cell ◽  
Human Osteosarcoma Cell Line ◽  
Collagen Production ◽  
Human Osteosarcoma ◽  
Traditional Japanese Medicine ◽  
Human Osteosarcoma Cell

Background: Orento, a traditional Japanese medicine, is known as Kampo medicine in Japan. We investigated the possible efficacy of Kampo medicine for periodontal disease. In this study, we examined the in vitro effects of orento on the proliferation of the inflammatory cytokines interleukin (IL)-6 and IL-8, the production of type 1 collagen, and the secretion of alkaline phosphatase (ALP) in the human osteosarcoma cell line Saos-2 (Saos-2 cells). Methods: The proliferation of Saos-2 cells was assessed by MTT assay. IL-6 and IL-8 levels, type 1 collagen production and ALP secretion were evaluated using enzyme-linked immunosorbent assay and ALP assays. Saos-2 cells were treated with or without 0.1, 1, 10, 100 and 1000 μg/mL of orento for 24 h. Results: Orento (10 μg/mL) significantly induced the proliferation of Saos-2 cells. At this concentration, orento suppressed IL-6 and IL-8 and enhanced type 1 collagen production and ALP secretion. Conclusions: These results indicate that orento controls the IL-6 and IL-8 secretion and cellular metabolism of osteoblasts, resulting in the secretion of early bone-related biomarkers.

Sign in / Sign up

Export Citation Format

Share Document