scholarly journals Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or diethylstilbestrol alters adult-type Leydig cell development in male offspring

2013 ◽  
Vol 15 (2) ◽  
pp. 261-268 ◽  
Author(s):  
Richard Ivell ◽  
Kee Heng ◽  
Helen Nicholson ◽  
Ravinder Anand-Ivell
Keyword(s):  
Leydig Cell ◽  
Dibutyl Phthalate ◽  
Cell Development ◽  
Maternal Exposure ◽  
Male Offspring ◽  
Adult Type

scholarly journals Transient Hypothyroidism: Dual Effect on Adult-Type Leydig Cell and Sertoli Cell Development

2017 ◽  
Vol 8 ◽  
Author(s):  
Eddy Rijntjes ◽  
Marcos L. M. Gomes ◽  
Nina Zupanič ◽  
Hans J. M. Swarts ◽  
Jaap Keijer ◽  
...  
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Development ◽  
Dual Effect ◽  
Adult Type ◽  
Transient Hypothyroidism

scholarly journals Prenatal induced chronic dietary hypothyroidism delays but does not block adult-type Leydig cell development

2009 ◽  
Vol 296 (2) ◽  
pp. E305-E314 ◽  
Author(s):  
Eddy Rijntjes ◽  
Hans J. M. Swarts ◽  
Ravinder Anand-Ivell ◽  
Katja J. Teerds
Keyword(s):  
Cell Population ◽  
Leydig Cell ◽  
Cell Formation ◽  
Production Capacity ◽  
Weight Ratio ◽  
Cell Development ◽  
Thyroid Stimulating Hormone ◽  
Testis Weight ◽  
Adult Type ◽  
Physiological Approach

Transient hypothyroidism induced by propyl-2-thiouracyl blocks postpartum Leydig cell development. In the present study, the effects of chronic hypothyroidism on the formation of this adult-type Leydig cell population were investigated, using a more physiological approach. Before mating, dams were put on a diet consisting of an iodide-poor feed supplemented with a low dose of perchlorate and, with their offspring, were kept on this diet until death. In the pups at day 12 postpartum, plasma thyroid-stimulating hormone levels were increased by 20-fold, whereas thyroxine and free tri-iodothyronine levels were severely depressed, confirming a hypothyroid condition. Adult-type progenitor Leydig cell formation and proliferation were reduced by 40–60% on days 16 and 28 postpartum. This was followed by increased Leydig cell proliferation at later ages, suggesting a possible slower developmental onset of the adult-type Leydig cell population under hypothyroid conditions. Testosterone levels were increased 2- to 10-fold in the hypothyroid animals between days 21 and 42 postpartum compared with the age-matched controls. Combined with the decreased presence of 5α-reductase, this implicates a lower production capacity of 5α-reduced androgens. In 84-day-old rats, after correction for body weight-to-testis weight ratio, plasma insulin-like factor-3 levels were 35% lower in the hypothyroid animals, suggestive of a reduced Leydig cell population. This is confirmed by a 37% reduction in the Sertoli cell-to-Leydig cell ratio in hypothyroid rats. In conclusion, we show that dietary-induced hypothyroidism delays but, unlike propyl-2-thiouracyl, does not block the development of the adult-type Leydig cell population.

Maternal exposure to zearalenone in masculinization window affects the fetal Leydig cell development in rat male fetus

2020 ◽  
Vol 263 ◽  
pp. 114357
Author(s):  
Peipei Pan ◽  
Feifei Ma ◽  
Keyang Wu ◽  
Yige Yu ◽  
Yang Li ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Cell Development ◽  
Maternal Exposure ◽  
Male Fetus

Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy

2021 ◽  
Vol 415 ◽  
pp. 115440
Author(s):  
Haoni Yan ◽  
Changchang Li ◽  
Cheng Zou ◽  
Xiu Xin ◽  
Xiaoheng Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Leydig Cell ◽  
Cell Development ◽  
Male Rats

scholarly journals Fibroblast Growth Factor 1 Promotes Rat Stem Leydig Cell Development

2019 ◽  
Vol 10 ◽  
Author(s):  
Lanlan Chen ◽  
Xiaoheng Li ◽  
Yiyan Wang ◽  
Tiantian Song ◽  
Huitao Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Leydig Cell ◽  
Cell Development ◽  
Fibroblast Growth

Testicular Organogenesis in the Fetal Calf: Interstitial Endocrine (Leydig) Cell Development

1985 ◽  
Vol 121 (2) ◽  
pp. 99-109 ◽  
Author(s):  
R.L. Hullinger ◽  
C.J.G. Wensing
Keyword(s):  
Leydig Cell ◽  
Cell Development
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