Testicular Organogenesis in the Fetal Calf: Interstitial Endocrine (Leydig) Cell Development

1985 ◽  
Vol 121 (2) ◽  
pp. 99-109 ◽  
Author(s):  
R.L. Hullinger ◽  
C.J.G. Wensing
Keyword(s):  
Leydig Cell ◽  
Cell Development

scholarly journals Transient Hypothyroidism: Dual Effect on Adult-Type Leydig Cell and Sertoli Cell Development

2017 ◽  
Vol 8 ◽  
Author(s):  
Eddy Rijntjes ◽  
Marcos L. M. Gomes ◽  
Nina Zupanič ◽  
Hans J. M. Swarts ◽  
Jaap Keijer ◽  
...  
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Development ◽  
Dual Effect ◽  
Adult Type ◽  
Transient Hypothyroidism

Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy

2021 ◽  
Vol 415 ◽  
pp. 115440
Author(s):  
Haoni Yan ◽  
Changchang Li ◽  
Cheng Zou ◽  
Xiu Xin ◽  
Xiaoheng Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Leydig Cell ◽  
Cell Development ◽  
Male Rats

scholarly journals Fibroblast Growth Factor 1 Promotes Rat Stem Leydig Cell Development

2019 ◽  
Vol 10 ◽  
Author(s):  
Lanlan Chen ◽  
Xiaoheng Li ◽  
Yiyan Wang ◽  
Tiantian Song ◽  
Huitao Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Leydig Cell ◽  
Cell Development ◽  
Fibroblast Growth

scholarly journals Distinct Roles for Steroidogenic factor 1 and Desert hedgehog Pathways in Fetal and Adult Leydig Cell Development

Endocrinology ◽  
2007 ◽  
Vol 148 (8) ◽  
pp. 3704-3710 ◽  
Author(s):  
Susan Y. Park ◽  
Minghan Tong ◽  
J. Larry Jameson
Keyword(s):  
Leydig Cell ◽  
Leydig Cells ◽  
External Genitalia ◽  
Cell Development ◽  
Mutant Mice ◽  
Paracrine Factor ◽  
Signaling Mechanism ◽  
Steroidogenic Factor 1 ◽  
Desert Hedgehog

Testicular Leydig cells produce testosterone and provide the hormonal environment required for male virilization and spermatogenesis. In utero, fetal Leydig cells (FLCs) are necessary for the development of the Wolffian duct and male external genitalia. Steroidogenic factor 1 (Sf1) is a transcriptional regulator of hormone biosynthesis genes, thus serving a central role in the Leydig cell. Desert hedgehog (Dhh), a Sertoli cell product, specifies the FLC lineage in the primordial gonad through a paracrine signaling mechanism. Postnatally, FLCs are replaced in the testis by morphologically distinct adult Leydig cells (ALCs). To study a putative interaction between Sf1 and Dhh, we crossed Sf1 heterozygous mutant mice with Dhh homozygous null mice to test the function of these two genes in vivo. All of the compound Sf1+/−; Dhh−/− mutants failed to masculinize and were externally female. However, embryonic gonads contained anastomotic testis cords with Sertoli cells and germ cells, indicating that sex reversal was not attributable to a fate switch of the early gonad. Instead, external feminization was attributable to the absence of differentiated FLCs in XY compound mutant mice. ALCs also failed to develop, suggesting either a dependence of ALCs on the prenatal establishment of Leydig cell precursors or that Sf1 and Dhh are both required for ALC maturation. In summary, this study provides genetic evidence that combinatorial expression of the paracrine factor Dhh and nuclear transcription factor Sf1 is required for Leydig cell development.

scholarly journals Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191934 ◽  
Author(s):  
Soria Eladak ◽  
Delphine Moison ◽  
Marie-Justine Guerquin ◽  
Gabriele Matilionyte ◽  
Karen Kilcoyne ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Germ Cell ◽  
Leydig Cell ◽  
Cell Function ◽  
Cell Development ◽  
Germ Cell Development ◽  
Fetal Testis ◽  
Leydig Cell Function

scholarly journals Prenatal induced chronic dietary hypothyroidism delays but does not block adult-type Leydig cell development

2009 ◽  
Vol 296 (2) ◽  
pp. E305-E314 ◽  
Author(s):  
Eddy Rijntjes ◽  
Hans J. M. Swarts ◽  
Ravinder Anand-Ivell ◽  
Katja J. Teerds
Keyword(s):  
Cell Population ◽  
Leydig Cell ◽  
Cell Formation ◽  
Production Capacity ◽  
Weight Ratio ◽  
Cell Development ◽  
Thyroid Stimulating Hormone ◽  
Testis Weight ◽  
Adult Type ◽  
Physiological Approach

Transient hypothyroidism induced by propyl-2-thiouracyl blocks postpartum Leydig cell development. In the present study, the effects of chronic hypothyroidism on the formation of this adult-type Leydig cell population were investigated, using a more physiological approach. Before mating, dams were put on a diet consisting of an iodide-poor feed supplemented with a low dose of perchlorate and, with their offspring, were kept on this diet until death. In the pups at day 12 postpartum, plasma thyroid-stimulating hormone levels were increased by 20-fold, whereas thyroxine and free tri-iodothyronine levels were severely depressed, confirming a hypothyroid condition. Adult-type progenitor Leydig cell formation and proliferation were reduced by 40–60% on days 16 and 28 postpartum. This was followed by increased Leydig cell proliferation at later ages, suggesting a possible slower developmental onset of the adult-type Leydig cell population under hypothyroid conditions. Testosterone levels were increased 2- to 10-fold in the hypothyroid animals between days 21 and 42 postpartum compared with the age-matched controls. Combined with the decreased presence of 5α-reductase, this implicates a lower production capacity of 5α-reduced androgens. In 84-day-old rats, after correction for body weight-to-testis weight ratio, plasma insulin-like factor-3 levels were 35% lower in the hypothyroid animals, suggestive of a reduced Leydig cell population. This is confirmed by a 37% reduction in the Sertoli cell-to-Leydig cell ratio in hypothyroid rats. In conclusion, we show that dietary-induced hypothyroidism delays but, unlike propyl-2-thiouracyl, does not block the development of the adult-type Leydig cell population.

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