A base pair between tRNA and 235 rRNA in the peptidyl transferase centre of the ribosome

Raymond R. Samaha; Rachel Green; Harry F. Noller

doi:10.1038/378419f0

A base pair between tRNA and 235 rRNA in the peptidyl transferase centre of the ribosome

Nature ◽

10.1038/378419f0 ◽

1995 ◽

Vol 378 (6555) ◽

pp. 419-419 ◽

Cited By ~ 1

Author(s):

Raymond R. Samaha ◽

Rachel Green ◽

Harry F. Noller

Keyword(s):

Base Pair ◽

Peptidyl Transferase ◽

Peptidyl Transferase Centre

Download Full-text

A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome

Nature ◽

10.1038/377309a0 ◽

1995 ◽

Vol 377 (6547) ◽

pp. 309-314 ◽

Cited By ~ 152

Author(s):

Raymond R. Samaha ◽

Rachel Green ◽

Harry F. Noller

Keyword(s):

Base Pair ◽

23S Rrna ◽

Peptidyl Transferase ◽

Peptidyl Transferase Centre

Download Full-text

Interaction of Arginine with the Ribosomal Peptidyl Transferase Centre

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1979.tb19741.x ◽

1979 ◽

Vol 101 (2) ◽

pp. 469-473 ◽

Cited By ~ 4

Author(s):

Enrique PALACIAN ◽

David VAZQUEZ

Keyword(s):

Peptidyl Transferase ◽

Peptidyl Transferase Centre

Download Full-text

Structure of a conserved RNA component of the peptidyl transferase centre

Natural Structural Biology ◽

10.1038/nsb1097-775 ◽

1997 ◽

Vol 4 (10) ◽

pp. 775-778 ◽

Cited By ~ 25

Author(s):

Elisabetta Viani Puglisi ◽

Rachel Green ◽

Harry F. Noller ◽

Joseph D. Puglisi

Keyword(s):

Peptidyl Transferase ◽

Peptidyl Transferase Centre

Download Full-text

Identifying the peptidyl transferase centre

Trends in Biochemical Sciences ◽

10.1016/0968-0004(82)90175-x ◽

1982 ◽

Vol 7 (11) ◽

pp. 385-386 ◽

Cited By ~ 14

Author(s):

R.A. Garrett ◽

Paul Wooley

Keyword(s):

Peptidyl Transferase ◽

Peptidyl Transferase Centre

Download Full-text

Structure of a protein L23-RNA complex located at the A-site domain of the ribosomal peptidyl transferase centre

Journal of Molecular Biology ◽

10.1016/0022-2836(84)90074-3 ◽

1984 ◽

Vol 179 (3) ◽

pp. 431-452 ◽

Cited By ~ 31

Author(s):

Birte Vester ◽

Roger A. Garrett

Keyword(s):

Peptidyl Transferase ◽

Peptidyl Transferase Centre ◽

A Site ◽

Rna Complex

Download Full-text

Sequence complementarity at the ribosomal Peptidyl Transferase Centre implies self-replicating origin

FEBS Letters ◽

10.1002/1873-3468.12781 ◽

2017 ◽

Vol 591 (20) ◽

pp. 3252-3258 ◽

Cited By ~ 5

Author(s):

Ilana Agmon

Keyword(s):

Peptidyl Transferase ◽

Sequence Complementarity ◽

Peptidyl Transferase Centre

Download Full-text

Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes: Binding of UACCA-Leu to 50 S subunits

FEBS Letters ◽

10.1016/0014-5793(71)80546-x ◽

1971 ◽

Vol 13 (4) ◽

pp. 247-251 ◽

Cited By ~ 74

Author(s):

M.L. Celma ◽

R.E. Monro ◽

D. Vazquez

Keyword(s):

Binding Sites ◽

Peptidyl Transferase ◽

E Coli ◽

Peptidyl Transferase Centre

Download Full-text

Antibiotic Action on the Ribosomal Peptidyl Transferase Centre

Drug Receptor Interactions in Antimicrobial Chemotherapy - Topics in Infectious Diseases ◽

10.1007/978-3-7091-8405-9_14 ◽

1975 ◽

pp. 193-216 ◽

Cited By ~ 2

Author(s):

D. Vazquez ◽

M. Barbacid ◽

R. Fernandez-Muñoz

Keyword(s):

Peptidyl Transferase ◽

Antibiotic Action ◽

Peptidyl Transferase Centre

Download Full-text

The Involvement of Sulphydryl Groups in the Peptidyl Transferase Centre of Eukaryotic Ribosomes

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1975.tb09806.x ◽

1975 ◽

Vol 50 (2) ◽

pp. 317-323 ◽

Cited By ~ 16

Author(s):

Luis CARRASCO ◽

David VAZQUEZ

Keyword(s):

Peptidyl Transferase ◽

Sulphydryl Groups ◽

Peptidyl Transferase Centre

Download Full-text

Ribosome crystallography: catalysis and evolution of peptide-bond formation, nascent chain elongation and its co-translational folding

Biochemical Society Transactions ◽

10.1042/bst0330488 ◽

2005 ◽

Vol 33 (3) ◽

pp. 488-492 ◽

Cited By ~ 12

Author(s):

A. Bashan ◽

A. Yonath

Keyword(s):

Bond Formation ◽

Peptide Bond ◽

Trigger Factor ◽

Chain Elongation ◽

Peptide Bond Formation ◽

Peptidyl Transferase ◽

Chemical Catalysis ◽

Nascent Chain ◽

Peptidyl Transferase Centre ◽

Folding Space

A ribosome is a ribozyme polymerizing amino acids, exploiting positional- and substrate-mediated chemical catalysis. We showed that peptide-bond formation is facilitated by the ribosomal architectural frame, provided by a sizable symmetry-related region in and around the peptidyl transferase centre, suggesting that the ribosomal active site was evolved by gene fusion. Mobility in tunnel components is exploited for elongation arrest as well as for trafficking nascent proteins into the folding space bordered by the bacterial chaperone, namely the trigger factor.

Download Full-text