Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

Nature ◽  
1995 ◽  
Vol 375 (6533) ◽  
pp. 700-704 ◽  
Author(s):  
Peter L. Roach ◽  
Ian J. Clifton ◽  
Vilmos Fülöp ◽  
Karl Harlos ◽  
Geoffrey J. Barton ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Structural Family ◽  
Isopenicillin N

The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site

FEBS Letters ◽  
2013 ◽  
Vol 587 (16) ◽  
pp. 2705-2709 ◽  
Author(s):  
Ian J. Clifton ◽  
Wei Ge ◽  
Robert M. Adlington ◽  
Jack E. Baldwin ◽  
Peter J. Rutledge
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Oxygen Binding ◽  
Substrate Analogue ◽  
Isopenicillin N

scholarly journals Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: Homology of the AhpD-like structural family

2011 ◽  
Vol 11 (1) ◽  
pp. 27 ◽  
Author(s):  
Teresa E Clarke ◽  
Vladimir Romanov ◽  
Yuri N Chirgadze ◽  
Chananat Klomsiri ◽  
Gera Kisselman ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Pseudomonas Aeruginosa ◽  
Structural Family ◽  
Alkyl Hydroperoxidase

scholarly journals 1.8 Å resolution crystal structure of the carbapenem intrinsic resistance protein CarF

2017 ◽  
Vol 73 (7) ◽  
pp. 549-556
Author(s):  
Evelyn M. Tichy ◽  
Steven W. Hardwick ◽  
Ben F. Luisi ◽  
George P. C. Salmond
Keyword(s):  
Crystal Structure ◽  
Host Organism ◽  
Intrinsic Resistance ◽  
Synthetic Pathway ◽  
Structural Family ◽  
Natural Production ◽  
Resistance Function ◽  
Lactam Antibiotic ◽  
Resistance Protein

The natural production of the β-lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self-intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance function has been derived.

The crystal structure of isopenicillin N synthase with δ-(l-α-aminoadipoyl)-l-cysteinyl-d-methionine reveals thioether coordination to iron

2011 ◽  
Vol 516 (2) ◽  
pp. 103-107 ◽  
Author(s):  
Ian J. Clifton ◽  
Wei Ge ◽  
Robert M. Adlington ◽  
Jack E. Baldwin ◽  
Peter J. Rutledge
Keyword(s):  
Crystal Structure ◽  
Isopenicillin N

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue

2013 ◽  
Vol 530 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Adam Daruzzaman ◽  
Ian J. Clifton ◽  
Robert M. Adlington ◽  
Jack E. Baldwin ◽  
Peter J. Rutledge
Keyword(s):  
Crystal Structure ◽  
Substrate Analogue ◽  
Isopenicillin N

The crystal structure of anlll-configured depsipeptide substrate analogue bound to isopenicillin N synthase

2010 ◽  
Vol 8 (1) ◽  
pp. 122-127 ◽  
Author(s):  
Wei Ge ◽  
Ian J. Clifton ◽  
Jeanette E. Stok ◽  
Robert M. Adlington ◽  
Jack E. Baldwin ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Substrate Analogue ◽  
Isopenicillin N

Crystal Structure Determination of Glycerol-Containing Lipids from Electron Diffraction Data. Use of Analog Compounds Based upon Configurational Isomers of Cyclopentane-1, 2, 3-TRIOL

1977 ◽  
Vol 35 ◽  
pp. 24-25
Author(s):  
Douglas L. Dorset ◽  
Anthony J. Hancock
Keyword(s):  
Crystal Structure ◽  
Electron Diffraction ◽  
Diffraction Data ◽  
Structure Determination ◽  
Crystal Surface ◽  
Coherent Scattering ◽  
Crystal Structure Determination ◽  
Electron Diffraction Data ◽  
Polar Group ◽  
Axis Orientation

Lipids containing long polymethylene chains were among the first compounds subjected to electron diffraction structure analysis. It was only recently realized, however, that various distortions of thin lipid microcrystal plates, e.g. bends, polar group and methyl end plane disorders, etc. (1-3), restrict coherent scattering to the methylene subcell alone, particularly if undistorted molecular layers have well-defined end planes. Thus, ab initio crystal structure determination on a given single uncharacterized natural lipid using electron diffraction data can only hope to identify the subcell packing and the chain axis orientation with respect to the crystal surface. In lipids based on glycerol, for example, conformations of long chains and polar groups about the C-C bonds of this moiety still would remain unknown.One possible means of surmounting this difficulty is to investigate structural analogs of the material of interest in conjunction with the natural compound itself. Suitable analogs to the glycerol lipids are compounds based on the three configurational isomers of cyclopentane-1,2,3-triol shown in Fig. 1, in which three rotameric forms of the natural glycerol derivatives are fixed by the ring structure (4-7).

Spherulitic crystal growth in the prodissoconch larval of Crassostrea virginica

1983 ◽  
Vol 41 ◽  
pp. 518-519
Author(s):  
George G. Cocks ◽  
Louis Leibovitz ◽  
DoSuk D. Lee
Keyword(s):  
Crystal Structure ◽  
Crassostrea Virginica ◽  
Crystal Orientation ◽  
Developmental Changes ◽  
Gastrula Stage ◽  
Orthorhombic Crystal ◽  
Orthorhombic Crystal Structure ◽  
Stages Of Growth ◽  
Early Stages ◽  
Initial Deposition

Our understanding of the structure and the formation of inorganic minerals in the bivalve shells has been considerably advanced by the use of electron microscope. However, very little is known about the ultrastructure of valves in the larval stage of the oysters. The present study examines the developmental changes which occur between the time of conception to the early stages of Dissoconch in the Crassostrea virginica(Gmelin), focusing on the initial deposition of inorganic crystals by the oysters.The spawning was induced by elevating the temperature of the seawater where the adult oysters were conditioned. The eggs and sperm were collected separately, then immediately mixed for the fertilizations to occur. Fertilized animals were kept in the incubator where various stages of development were stopped and observed. The detailed analysis of the early stages of growth showed that CaCO3 crystals(aragonite), with orthorhombic crystal structure, are deposited as early as gastrula stage(Figuresla-b). The next stage in development, the prodissoconch, revealed that the crystal orientation is in the form of spherulites.

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