scholarly journals 1.8 Å resolution crystal structure of the carbapenem intrinsic resistance protein CarF

2017 ◽  
Vol 73 (7) ◽  
pp. 549-556
Author(s):  
Evelyn M. Tichy ◽  
Steven W. Hardwick ◽  
Ben F. Luisi ◽  
George P. C. Salmond
Keyword(s):  
Crystal Structure ◽  
Host Organism ◽  
Intrinsic Resistance ◽  
Synthetic Pathway ◽  
Structural Family ◽  
Natural Production ◽  
Resistance Function ◽  
Lactam Antibiotic ◽  
Resistance Protein

The natural production of the β-lactam antibiotic carbapenem in bacteria involves a group of enzymes that form a synthetic pathway as well as proteins that protect the cell from self-intoxification by the products. Here, the crystal structure of CarF, one of the two proteins that confer resistance to synthesis of the antibiotic in the host organism, is reported. The CarF fold places it within a widely occurring structural family, indicating an ancient structural origin from which the resistance function has been derived.

scholarly journals Crystal Structure of the Carbapenem Intrinsic Resistance Protein CarG

2014 ◽  
Vol 426 (9) ◽  
pp. 1958-1970 ◽  
Author(s):  
E.M. Tichy ◽  
B.F. Luisi ◽  
G.P.C. Salmond
Keyword(s):  
Crystal Structure ◽  
Intrinsic Resistance ◽  
Resistance Protein

Crystal Structure of Tabtoxin Resistance Protein Complexed with Acetyl Coenzyme A Reveals the Mechanism for β-Lactam Acetylation

2003 ◽  
Vol 325 (5) ◽  
pp. 1019-1030 ◽  
Author(s):  
Hongzhen He ◽  
Yi Ding ◽  
Mark Bartlam ◽  
Fei Sun ◽  
Yi Le ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Coenzyme A ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme ◽  
Resistance Protein

scholarly journals 1.6 Å Crystal structure of a PA2721 protein from pseudomonas aeruginosa-A potential drug-resistance protein

2006 ◽  
Vol 63 (4) ◽  
pp. 1102-1105 ◽  
Author(s):  
B. Nocek ◽  
M. Cuff ◽  
E. Evdokimova ◽  
A. Edwards ◽  
A. Joachimiak ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Pseudomonas Aeruginosa ◽  
Drug Resistance ◽  
Potential Drug ◽  
Resistance Protein

scholarly journals Crystal structure of theMelampsora linieffector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P

2017 ◽  
Vol 19 (5) ◽  
pp. 1196-1209 ◽  
Author(s):  
Xiaoxiao Zhang ◽  
Nadya Farah ◽  
Laura Rolston ◽  
Daniel J. Ericsson ◽  
Ann-Maree Catanzariti ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Disease Resistance ◽  
Nuclear Function ◽  
Disease Resistance Protein ◽  
Resistance Protein

scholarly journals Crystal structure of dimethyl 2-((2Z,5Z)-5-(2-methoxy-2-oxoethylidene)-2-{(E)-[2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enylidene]hydrazinylidene}-4-oxothiazolidin-3-yl)fumarate

2017 ◽  
Vol 73 (2) ◽  
pp. 296-299 ◽  
Author(s):  
Abdellah N'ait Ousidi ◽  
My Youssef Ait Itto ◽  
Aziz Auhmani ◽  
Abdelkhalek Riahi ◽  
Abdelwahed Auhmani ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Title Compound ◽  
Synthetic Pathway ◽  
X Ray ◽  
Compound C ◽  
Pure Product

The crystal structure and the conformation of the title compound, C22H27N3O7S, were determined from the synthetic pathway and by X-ray analysis. This compound is a new 4-thiazolidinone derivative prepared and isolated as pure product from thiosemicarbazone carvone. The molecule is built up from an oxothiazolidine ring tetrasubstituted by a methoxy–oxoethylidene, a maleate, an oxygen and a cyclohexylidene–hydrazone. The cyclohexylidene ring is statistically disordered over two positions, resulting in an inversion of configuration for the substituted carbon.

scholarly journals Crystal structure of (S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-N-methoxy-N-methylpropanamide (Fernholz Weinreb amide)

2015 ◽  
Vol 71 (3) ◽  
pp. 275-277 ◽  
Author(s):  
Elvar Ørn Viktorsson ◽  
Ove Alexander Høgmoen Åstrand ◽  
Rasha Sabah Haseeb ◽  
Carl Henrik Görbitz ◽  
Pål Rongved
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonds ◽  
Title Compound ◽  
High Yield ◽  
Carbonyl Groups ◽  
Asymmetric Unit ◽  
Synthetic Pathway ◽  
Compound C ◽  
Weinreb Amide ◽  
Important Intermediate

The literature compound 3β-hydroxy-bisnor-5-cholenic aldehyde is an important intermediate for the synthesis of new modulators of the nuclear oxysterol receptor LiverX. As part of our ongoing search for new LXR antagonists, the title compound, C24H39NO3, has proven to be an important intermediate in our new synthetic pathway, giving the corresponding aldehyde in high yield and in only three steps from the commercially available 3β-hydroxy-bisnor-5-cholenic acid. The title amide crystallized with two molecules in the asymmetric unit, linked into helices by O—H...O hydrogen bonds involving the hydroxy and carbonyl groups.

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