A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

Nature ◽  
1993 ◽  
Vol 364 (6438) ◽  
pp. 626-632 ◽  
Author(s):  
Stuart A. Lipton ◽  
Yun-Beom Choi ◽  
Zhuo-Hua Pan ◽  
Sizheng Z. Lei ◽  
Huei-Sheng Vincent Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitroso Compounds

Can nitric oxide be spin trapped by nitrone and nitroso compounds?

1994 ◽  
Vol 1201 (1) ◽  
pp. 118-124 ◽  
Author(s):  
S POU ◽  
L KEATON ◽  
W SURICHAMORN ◽  
P FRIGILLANA ◽  
G ROSEN
Keyword(s):  
Nitric Oxide ◽  
Nitroso Compounds

Interactions of nitric oxide and organic nitroso compounds with metalloporphyrins and heme

2000 ◽  
Vol 04 (04) ◽  
pp. 354-357 ◽  
Author(s):  
GEORGE B. RICHTER-ADDO
Keyword(s):  
Nitric Oxide ◽  
Excited State ◽  
Electronic Properties ◽  
Ground State ◽  
Bond Formation ◽  
Metal Center ◽  
Nitroso Compounds ◽  
Model Compounds ◽  
Axial Ligands ◽  
Metal Nitrosyls

The chemistry of nitric oxide (NO) has taken on new dimensions since the discovery, about a decade ago, of a myriad of biological events that NO participates in. Many of the foundations of metal-NO chemistry were laid out earlier by inorganic chemists and biochemists investigating the structures and electronic properties of the heme-NO moiety or its model compounds. Certainly, the persistent work over the last three decades by chemists working with metal nitrosyls has paid off. Current areas of research in heme-NO chemistry include (i) how the NO group approaches and binds to the metal center (or how it dissociates from the metal center); (ii) the ground state and excited state geometries of the metal-NOfragment; (iii) effects of the trans axial ligands on NO orientation and/or dissociation; and (iv) N-N bond formation from NO molecules catalyzed by heme groups.

Action profiles of nitric oxide, S-nitroso-L-cysteine, SNP, and NANC responses in opossum lower esophageal sphincter

1992 ◽  
Vol 262 (5) ◽  
pp. G840-G846 ◽  
Author(s):  
M. A. Knudsen ◽  
D. Svane ◽  
A. Tottrup
Keyword(s):  
Nitric Oxide ◽  
Methylene Blue ◽  
Lower Esophageal Sphincter ◽  
Circular Muscle ◽  
Isometric Tension ◽  
Nitroso Compounds ◽  
Field Stimulation ◽  
Superoxide Anions ◽  
Esophageal Sphincter ◽  
Action Profile

Circular muscle strips from opossum lower esophageal sphincter were suspended in organ baths for measurement of isometric tension. Nonadrenergic noncholinergic (NANC) inhibitory nerves were stimulated by means of transmural field stimulation. This induced frequency-dependent relaxations of the muscle strips. Methylene blue (3 x 10(-6) M; inhibits guanylate cyclase) and pyrogallol (10(-4) M; generates superoxide anions) had no influence on relaxations, whereas oxyhemoglobin [10(-5) M; binds nitric oxide (NO) and other nitroso compounds extracellularly] inhibited relaxations at all frequencies. NO concentration dependently relaxed the muscle strips. Pyrogallol (10(-4) M) and methylene blue (3 x 10(-6) M) inhibited and oxyhemoglobin (10(-5) M) nearly abolished relaxation induced by NO. S-nitroso-L-cysteine caused concentration-dependent relaxations of the muscle strips, which were inhibited by pyrogallol (10(-4) M), whereas methylene blue (3 x 10(-6) M) augmented the action of S-nitroso-L-cysteine. Methylene blue (3 x 10(-6) M) had no influence on the concentration-dependent relaxations caused by sodium nitroprusside (SNP). Oxyhemoglobin (10(-5) M), and to a lesser extent pyrogallol (10(-4) M), both inhibited the effects of SNP. The action profiles for S-nitroso-L-cysteine, NO, and SNP differed from the action profile for NANC nerve-mediated response. Although pyrogallol inhibited the effects of SNP, the action profile generally resembled the action profile for NANC responses more closely than did the profiles for S-nitroso-L-cysteine or NO. In conclusion, of the nitroso compounds studied, SNP most closely resembled the response to NANC nerve stimulation. Neither NO nor S-nitroso-L-cysteine individually mimicked the NANC response.

Stabile und instabile Produkte bei der Reaktion von 2.2-Diphenyl-1,2-dihydrochinolinnitroxid-Radikalen mit Stickstoffmonoxid / Stable and Unstable Products on the Reaction of 2.2-Diphenyl-1,2-dihydroquinolinenitroxide Radicals with Nitric Oxide

1994 ◽  
Vol 49 (8) ◽  
pp. 1041-1050 ◽  
Author(s):  
Horst Weber ◽  
Andreas Grzesiok ◽  
Reiner Sustmann ◽  
Hans-Gert Korth
Keyword(s):  
Nitric Oxide ◽  
Nitro Compounds ◽  
Nitroso Compounds ◽  
Mechanism Of The Reaction

The stable 2,2-diphenyl-1,2-dihydroquinolinenitroxide radicals 1 react with nitric oxide (NO) to form the stable nitro compounds 2 and 3 as main products. The stable dinitro compounds 6 and 1,2-dihydroquinolines 7 are formed in minor yield as side-products accom­panied with the unstable N-nitroso compounds 4 and 5, which further decompose to form the stable products mentioned above. The proposed mechanism of the reaction is discussed in terms of homolytical processes and is supported by PM 3 calculations.

Sign in / Sign up

Export Citation Format

Share Document