Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

Nature ◽  
1993 ◽  
Vol 362 (6415) ◽  
pp. 87-91 ◽  
Author(s):  
Michael J. Eck ◽  
Steven E. Shoelson ◽  
Stephen C. Harrison
Keyword(s):  
High Affinity ◽  
Src Homology 2 ◽  
Src Homology ◽  
Src Homology 2 Domain

scholarly journals IL-6 blocks a discrete early step in lymphopoiesis

Blood ◽  
2005 ◽  
Vol 106 (3) ◽  
pp. 879-885 ◽  
Author(s):  
Kazuhiko Maeda ◽  
Yoshihiro Baba ◽  
Yoshinori Nagai ◽  
Kozo Miyazaki ◽  
Alexander Malykhin ◽  
...  
Keyword(s):  
Target Cells ◽  
Hematopoietic Progenitors ◽  
Early Step ◽  
Hematopoietic Stem ◽  
Lymphoid Lineage ◽  
Src Homology 2 ◽  
Multipotent Progenitors ◽  
Src Homology ◽  
Src Homology 2 Domain

Abstract Animals lacking Src homology 2 domain-containing inositol 5-phosphatase (SHIP) display a reduction in lymphopoiesis and a corresponding enhancement of myelopoiesis. These effects are mediated at least in part by elevated levels of interleukin 6 (IL-6). Here, we show the lymphopoiesis block in SHIP–/– mice is due to suppression of the lymphoid lineage choice by uncommitted progenitors. The suppression can be reproduced in vitro with recombinant IL-6, and IL-6 acts directly on hematopoietic progenitors. The block is partially overcome in SHIP–/– IL-6–/– double-deficient animals. IL-6 does not suppress but actually enhances proliferation of lymphoid-committed progenitors, indicating the IL-6 target cells are hematopoietic stem cells or multipotent progenitors. The findings suggest a mechanism for the lymphopenia that accompanies proinflammatory diseases.

scholarly journals FP12.03 SRC-Homology 2 Domain-Containing Phosphatase 2 (SHP2) in Resected Lung Adenocarcinoma (LUAD)

2021 ◽  
Vol 16 (3) ◽  
pp. S217-S218
Author(s):  
M. Ito ◽  
J. Codony-Servat ◽  
A. Giménez-Capitán ◽  
M. Serra-Mitjans ◽  
F. Pérez-Ochoa ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Src Homology 2 ◽  
Src Homology ◽  
Src Homology 2 Domain

scholarly journals Integrin-linked kinase (ILK) and src homology 2 domain-containing phosphatase 2 (SHP2): Novel targets in EGFR-mutation positive non-small cell lung cancer (NSCLC)

EBioMedicine ◽  
2019 ◽  
Vol 39 ◽  
pp. 207-214 ◽  
Author(s):  
Niki Karachaliou ◽  
Andres Felipe Cardona ◽  
Jillian Wilhelmina Paulina Bracht ◽  
Erika Aldeguer ◽  
Ana Drozdowskyj ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Egfr Mutation ◽  
Small Cell ◽  
Small Cell Lung ◽  
Src Homology 2 ◽  
Integrin Linked Kinase ◽  
Src Homology ◽  
Novel Targets ◽  
Src Homology 2 Domain

scholarly journals Structural Determinants of the Interaction between the erbB2 Receptor and the Src Homology 2 Domain of Grb7

1997 ◽  
Vol 272 (13) ◽  
pp. 8490-8497 ◽  
Author(s):  
Peter W. Janes ◽  
Martin Lackmann ◽  
W. Bret Church ◽  
Georgina M. Sanderson ◽  
Robert L. Sutherland ◽  
...  
Keyword(s):  
Structural Determinants ◽  
Src Homology 2 ◽  
Erbb2 Receptor ◽  
Src Homology ◽  
Src Homology 2 Domain
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