Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor

Coleman; Zhiyong Ren; Pijus K. Mandal; Arlin G. Cameron; Garrett A. Dyer; Seema Muranjan; Martin Campbell; Xiaomin Chen; John S. McMurray

doi:10.1021/jm050513m

Investigation of the Binding Determinants of Phosphopeptides Targeted to the Src Homology 2 Domain of the Signal Transducer and Activator of Transcription 3. Development of a High-Affinity Peptide Inhibitor

Journal of Medicinal Chemistry ◽

10.1021/jm050513m ◽

2005 ◽

Vol 48 (21) ◽

pp. 6661-6670 ◽

Cited By ~ 90

Author(s):

Coleman ◽

Zhiyong Ren ◽

Pijus K. Mandal ◽

Arlin G. Cameron ◽

Garrett A. Dyer ◽

...

Keyword(s):

Peptide Inhibitor ◽

Signal Transducer ◽

High Affinity ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain ◽

Affinity Peptide ◽

Binding Determinants ◽

Transcription 3

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Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

Nature ◽

10.1038/362087a0 ◽

1993 ◽

Vol 362 (6415) ◽

pp. 87-91 ◽

Cited By ~ 348

Author(s):

Michael J. Eck ◽

Steven E. Shoelson ◽

Stephen C. Harrison

Keyword(s):

High Affinity ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domain

JAK-STAT ◽

10.4161/jkst.22682 ◽

2012 ◽

Vol 1 (4) ◽

pp. 263-347 ◽

Cited By ~ 6

Author(s):

John S. McMurray ◽

Pijus K. Mandal ◽

Warren S. Liao ◽

Jim Klostergaard ◽

Fredika M. Robertson

Keyword(s):

Selective Inhibition ◽

Sh2 Domain ◽

Signal Transducer ◽

Src Homology 2 ◽

Src Homology ◽

Transcription 3

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Changes in Signal Transducer and Activator of Transcription 3 (STAT3) Dynamics Induced by Complexation with Pharmacological Inhibitors of Src Homology 2 (SH2) Domain Dimerization

Journal of Biological Chemistry ◽

10.1074/jbc.m114.595454 ◽

2014 ◽

Vol 289 (47) ◽

pp. 32538-32547 ◽

Cited By ~ 23

Author(s):

Diana Resetca ◽

Sina Haftchenary ◽

Patrick T. Gunning ◽

Derek J. Wilson

Keyword(s):

Sh2 Domain ◽

Signal Transducer ◽

Src Homology 2 ◽

Src Homology ◽

Transcription 3

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Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma

Journal of Medicinal Chemistry ◽

10.1021/jm3017255 ◽

2013 ◽

Vol 56 (18) ◽

pp. 7190-7200 ◽

Cited By ~ 25

Author(s):

Brent D. G. Page ◽

Danielle C. Croucher ◽

Zhi Hua Li ◽

Sina Haftchenary ◽

Victor H. Jimenez-Zepeda ◽

...

Keyword(s):

Multiple Myeloma ◽

Small Molecule ◽

Signal Transducer ◽

Protein Activation ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3

Journal of Medicinal Chemistry ◽

10.1021/jm2000882 ◽

2011 ◽

Vol 54 (10) ◽

pp. 3549-3563 ◽

Cited By ~ 91

Author(s):

Pijus K. Mandal ◽

Fengqin Gao ◽

Zhen Lu ◽

Zhiyong Ren ◽

Rajagopal Ramesh ◽

...

Keyword(s):

Sh2 Domain ◽

Signal Transducer ◽

Src Homology 2 ◽

Src Homology ◽

Transcription 3

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Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)

International Journal of Peptide Research and Therapeutics ◽

10.1007/s10989-012-9313-0 ◽

2012 ◽

Vol 19 (1) ◽

pp. 3-12 ◽

Cited By ~ 8

Author(s):

Pijus K. Mandal ◽

Zhiyong Ren ◽

Xiaomin Chen ◽

Kumar Kaluarachchi ◽

Warren S.-L. Liao ◽

...

Keyword(s):

Sh2 Domain ◽

Signal Transducer ◽

Src Homology 2 ◽

Structure Activity ◽

Src Homology ◽

Transcription 3

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Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)53920-x ◽

1993 ◽

Vol 268 (3) ◽

pp. 1775-1779 ◽

Cited By ~ 1

Author(s):

G. Zhu ◽

S.J. Decker ◽

B.J. Mayer ◽

A.R. Saltiel

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Direct Analysis ◽

Src Homology 2 ◽

Src Homology ◽

Epidermal Growth ◽

Src Homology 2 Domain

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Evidence for autoinhibitory regulation of the c-src gene product. A possible interaction between the src homology 2 domain and autophosphorylation site.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54051-5 ◽

1993 ◽

Vol 268 (2) ◽

pp. 1132-1140

Author(s):

Y. Fukami ◽

K. Sato ◽

K. Ikeda ◽

K. Kamisango ◽

K. Koizumi ◽

...

Keyword(s):

Gene Product ◽

Src Homology 2 ◽

Src Gene ◽

Src Homology ◽

Src Homology 2 Domain ◽

Autophosphorylation Site

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Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)31807-0 ◽

1994 ◽

Vol 269 (35) ◽

pp. 22427-22432 ◽

Cited By ~ 7

Author(s):

H. Kihara ◽

R.P. Siraganian

Keyword(s):

Ige Receptor ◽

High Affinity ◽

Src Homology 2 ◽

Src Homology ◽

High Affinity Ige Receptor

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Investigating the reason for loss-of-function of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) caused by Y279C mutation through molecular dynamics simulation

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2019.1634641 ◽

2019 ◽

Vol 38 (9) ◽

pp. 2509-2520 ◽

Cited By ~ 2

Author(s):

Wen-Shan Liu ◽

Rui-Rui Wang ◽

Wei-Ya Li ◽

Mei Rong ◽

Chi-Lu Liu ◽

...

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulation ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Dynamics Simulation ◽

Loss Of Function ◽

Protein Tyrosine ◽

Src Homology 2 ◽

Src Homology ◽

Src Homology 2 Domain

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