Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

Nature ◽  
1991 ◽  
Vol 351 (6329) ◽  
pp. 714-718 ◽  
Author(s):  
David S. Bredt ◽  
Paul M. Hwang ◽  
Charles E. Glatt ◽  
Charles Lowenstein ◽  
Randall R. Reed ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Cytochrome P 450

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

Biochemistry ◽  
1992 ◽  
Vol 31 (29) ◽  
pp. 6627-6631 ◽  
Author(s):  
Kimberly A. White ◽  
Michael A. Marletta
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Cytochrome P 450

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 ◽  
Vol 1 (4) ◽  
pp. 86
Author(s):  
D.S. Bredt ◽  
P.M. Hwang ◽  
C.E. Glatt ◽  
C. Lowenstein ◽  
R.R. Reed ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Cytochrome P 450

scholarly journals Characterization of Inducible Nitric-oxide Synthase by Cytochrome P-450 Substrates and Inhibitors

1997 ◽  
Vol 272 (2) ◽  
pp. 977-983 ◽  
Author(s):  
Stephan K. Grant ◽  
Barbara G. Green ◽  
Regina Wang ◽  
Stephen G. Pacholok ◽  
John W. Kozarich
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Cytochrome P 450 ◽  
Inducible Nitric Oxide

Difference in the inhibition of nitric oxide synthase and cytochrome P-450 by some H2-antagonists

1997 ◽  
Vol 11 (6) ◽  
pp. 775-778
Author(s):  
J.B.G. Paquay ◽  
M.Ten Bolscher ◽  
H.-P. Voss ◽  
H. Timmerman ◽  
A. Bast
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
H2 Antagonists ◽  
Oxide Synthase ◽  
Cytochrome P 450

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

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