The Soluble Guanylyl Cyclase Inhibitor 1H-[1,2,4]Oxadiazolo[4,3,-a]quinoxalin-1-one Is a Nonselective Heme Protein Inhibitor of Nitric Oxide Synthase and Other Cytochrome P-450 Enzymes Involved in Nitric Oxide Donor Bioactivation

1999 ◽  
Vol 56 (2) ◽  
pp. 243-253 ◽  
Author(s):  
Martin Feelisch ◽  
Peter Kotsonis ◽  
Jan Siebe ◽  
Bernd Clement ◽  
Harald H. H. W. Schmidt
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Heme Protein ◽  
Nitric Oxide Donor ◽  
Protein Inhibitor ◽  
Oxide Synthase ◽  
Cytochrome P 450

scholarly journals Synaptic Localization of Nitric Oxide Synthase and Soluble Guanylyl Cyclase in the Hippocampus

2002 ◽  
Vol 22 (20) ◽  
pp. 8961-8970 ◽  
Author(s):  
Alain Burette ◽  
Ulrike Zabel ◽  
Richard J. Weinberg ◽  
Harald H. H. W. Schmidt ◽  
Juli G. Valtschanoff
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Synaptic Localization ◽  
Oxide Synthase

TNF-alpha and IFN-gamma induce expression of nitric oxide synthase in cultured rat medullary interstitial cells

1995 ◽  
Vol 269 (2) ◽  
pp. F212-F217 ◽  
Author(s):  
K. S. Lau ◽  
O. Nakashima ◽  
G. R. Aalund ◽  
L. Hogarth ◽  
K. Ujiie ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Nitric Oxide Synthase ◽  
Vascular Smooth Muscle ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Tnf Alpha ◽  
No Production ◽  
Ifn Gamma ◽  
Oxide Synthase

Cytokines increase the expression of the inducible (type II) nitric oxide synthase (NOS) in macrophages, liver, and renal epithelial cells. Previously, we found that cultured rat medullary interstitial cells (RMIC) contain high levels of soluble guanylyl cyclase. To determine whether these cells can also produce NO, we studied the effects of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on NO production, NOS II mRNA, and NOS II protein expression. Both TNF-alpha and IFN-gamma, in the presence of a low concentration of the other cytokine, caused dose-dependent increases in NO production. Exposure to TNF-alpha and IFN-gamma stimulated the production of NOS II mRNA, as determined by Northern blotting. Restriction mapping of reverse transcription-polymerase chain reaction products indicated that normal cells contained macrophage NOS II, whereas cytokine-stimulated cells contained primarily vascular smooth muscle NOS II and some macrophage NOS II. The appearance of NOS II protein was demonstrated by Western blotting. RMIC cell guanosine 3',5'-cyclic monophosphate accumulation increased 129-fold in response to the cytokines. NOS inhibitors decreased nitrite production. We conclude that 1) TNF-alpha and IFN-gamma induce the expression of vascular smooth muscle NOS II and production of NO in RMIC, and 2) NO acts as an autocrine activator of the soluble guanylyl cyclase in RMIC.

Nitric oxide synthase and soluble guanylyl cyclase underlying the modulation of electrical oscillations in a central olfactory organ

2004 ◽  
Vol 62 (1) ◽  
pp. 14-30 ◽  
Author(s):  
Sayoko Fujie ◽  
Takehiro Yamamoto ◽  
Jun Murakami ◽  
Dai Hatakeyama ◽  
Hatsuki Shiga ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Olfactory Organ ◽  
Oxide Synthase

Constitutive Coexpression of Nitric Oxide Synthase-1 and Soluble Guanylyl Cyclase in Myoepithelial Cells of Mammary Glands in Mice

2005 ◽  
Vol 180 (3) ◽  
pp. 178-184 ◽  
Author(s):  
Achim Wöckel ◽  
Oliver Baum ◽  
Gerit Planitzer ◽  
Barbara Rothen-Rutishauser ◽  
Reinhart Gossrau ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Mammary Glands ◽  
Myoepithelial Cells ◽  
Nitric Oxide Synthase 1 ◽  
Oxide Synthase
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