The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

Nature ◽  
2000 ◽  
Vol 407 (6806) ◽  
pp. 920-923 ◽  
Author(s):  
Ping Wei ◽  
Jun Zhang ◽  
Margarete Egan-Hafley ◽  
Shuguang Liang ◽  
David D. Moore
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor ◽  
Xenobiotic Induction

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

10.1038/87912 ◽  
2001 ◽  
Vol 7 (5) ◽  
pp. 584-590 ◽  
Author(s):  
Timothy W. Synold ◽  
Isabelle Dussault ◽  
Barry Marc Forman
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor ◽  
Orphan Nuclear Receptor

scholarly journals Extrahepatic Cancer Suppresses Nuclear Receptor–Regulated Drug Metabolism

2011 ◽  
Vol 17 (10) ◽  
pp. 3170-3180 ◽  
Author(s):  
Marina Kacevska ◽  
Michael R. Downes ◽  
Rohini Sharma ◽  
Ronald M. Evans ◽  
Stephen J. Clarke ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor

Oleuropein-induced accelerationof CYP-catalyzed drug metabolism: central role for nuclear receptor PPARα

2021 ◽  
pp. DMD-AR-2020-000302
Author(s):  
Foteini Malliou ◽  
Christina E. Andriopoulou ◽  
Frank J. Gonzalez ◽  
Aristeidis Kofinas ◽  
Alexios-Leandros Skaltsounis ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor

scholarly journals Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

Hepatology ◽  
2012 ◽  
Vol 56 (4) ◽  
pp. 1499-1508 ◽  
Author(s):  
Wei-Dong Chen ◽  
Xianghui Fu ◽  
Bingning Dong ◽  
Yan-Dong Wang ◽  
Steven Shiah ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor ◽  
Mouse Liver ◽  
Epigenetic Memory ◽  
Permanent Change

Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism

2004 ◽  
Vol 9 (10) ◽  
pp. 442-449 ◽  
Author(s):  
Wen Xie ◽  
Hirdesh Uppal ◽  
Simrat P.S Saini ◽  
Ying Mu ◽  
Joanna M Little ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor ◽  
Orphan Nuclear Receptor

A Nuclear Receptor-Mediated Xenobiotic Response and Its Implication in Drug Metabolism and Host Protection

2003 ◽  
Vol 4 (1) ◽  
pp. 59-72 ◽  
Author(s):  
J. Sonoda ◽  
J. Rosenfeld ◽  
L. Xu ◽  
R. Evans ◽  
W. Xie
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor ◽  
Host Protection ◽  
Xenobiotic Response
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