A Nuclear Receptor-Mediated Xenobiotic Response and Its Implication in Drug Metabolism and Host Protection

2003 ◽  
Vol 4 (1) ◽  
pp. 59-72 ◽  
Author(s):  
J. Sonoda ◽  
J. Rosenfeld ◽  
L. Xu ◽  
R. Evans ◽  
W. Xie
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor ◽  
Host Protection ◽  
Xenobiotic Response

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

10.1038/87912 ◽  
2001 ◽  
Vol 7 (5) ◽  
pp. 584-590 ◽  
Author(s):  
Timothy W. Synold ◽  
Isabelle Dussault ◽  
Barry Marc Forman
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor ◽  
Orphan Nuclear Receptor

scholarly journals The Nuclear Receptor Seven Up Regulates Genes Involved in Immunity and Xenobiotic Response in the Adult Drosophila Female Fat Body

2020 ◽  
Vol 10 (12) ◽  
pp. 4625-4635
Author(s):  
Lesley N. Weaver ◽  
Daniela Drummond-Barbosa
Keyword(s):  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Adult Female ◽  
Fat Body ◽  
Peripheral Tissues ◽  
Immune Genes ◽  
Xenobiotic Detoxification ◽  
Intrinsic Roles ◽  
Xenobiotic Response ◽  
Adult Drosophila

The physiology of organisms depends on inter-organ communication in response to changes in the environment. Nuclear receptors are broadly expressed transcription factors that respond to circulating molecules to control many biological processes, including immunity, detoxification, and reproduction. Although the tissue-intrinsic roles of nuclear receptors in reproduction have been extensively studied, there is increasing evidence that nuclear receptor signaling in peripheral tissues can also influence oogenesis. We previously showed that the Drosophila nuclear receptor Seven up (Svp) is required in the adult fat body to regulate distinct steps of oogenesis; however, the relevant downstream targets of Svp remain unknown. Here, we took an RNA sequencing approach to identify candidate Svp targets specifically in the adult female fat body that might mediate this response. svp knockdown in the adult female fat body significantly downregulated immune genes involved in the first line of pathogen defense, suggesting a role for Svp in stimulating early immunity. In addition, we found that Svp transcriptionally regulates genes involved in each step of the xenobiotic detoxification response. Based on these findings, we propose a testable model in which Svp functions in the adult female fat body to stimulate early defense against pathogens and facilitate detoxification as part of its mechanisms to promote oogenesis.

scholarly journals Extrahepatic Cancer Suppresses Nuclear Receptor–Regulated Drug Metabolism

2011 ◽  
Vol 17 (10) ◽  
pp. 3170-3180 ◽  
Author(s):  
Marina Kacevska ◽  
Michael R. Downes ◽  
Rohini Sharma ◽  
Ronald M. Evans ◽  
Stephen J. Clarke ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor

Oleuropein-induced accelerationof CYP-catalyzed drug metabolism: central role for nuclear receptor PPARα

2021 ◽  
pp. DMD-AR-2020-000302
Author(s):  
Foteini Malliou ◽  
Christina E. Andriopoulou ◽  
Frank J. Gonzalez ◽  
Aristeidis Kofinas ◽  
Alexios-Leandros Skaltsounis ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor

scholarly journals Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

Hepatology ◽  
2012 ◽  
Vol 56 (4) ◽  
pp. 1499-1508 ◽  
Author(s):  
Wei-Dong Chen ◽  
Xianghui Fu ◽  
Bingning Dong ◽  
Yan-Dong Wang ◽  
Steven Shiah ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Nuclear Receptor ◽  
Mouse Liver ◽  
Epigenetic Memory ◽  
Permanent Change

Humanized xenobiotic response in mice expressing nuclear receptor SXR

Nature ◽  
2000 ◽  
Vol 406 (6794) ◽  
pp. 435-439 ◽  
Author(s):  
Wen Xie ◽  
Joyce L. Barwick ◽  
Michael Downes ◽  
Bruce Blumberg ◽  
Cynthia M. Simon ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Xenobiotic Response
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