E-cadherin germline mutations in familial gastric cancer

Nature ◽  
10.1038/32918 ◽  
1998 ◽  
Vol 392 (6674) ◽  
pp. 402-405 ◽  
Author(s):  
Parry Guilford ◽  
Justin Hopkins ◽  
James Harraway ◽  
Maybelle McLeod ◽  
Ngahiraka McLeod ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Germline Mutations ◽  
Familial Gastric Cancer ◽  
E Cadherin

scholarly journals Germline mutations and polymorphic variants inMMR,E-cadherin andMYH genes associated with familial gastric cancer in Jiangsu of China

2006 ◽  
Vol 119 (11) ◽  
pp. 2592-2596 ◽  
Author(s):  
Yuanying Zhang ◽  
Xiaorong Liu ◽  
Yimei Fan ◽  
Jianhua Ding ◽  
Ailing Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Germline Mutations ◽  
Familial Gastric Cancer ◽  
Polymorphic Variants ◽  
E Cadherin

scholarly journals Germline mutations of E-cadherin gene in Korean familial gastric cancer patients

1999 ◽  
Vol 44 (3) ◽  
pp. 177-180 ◽  
Author(s):  
Kyong-Ah Yoon ◽  
J.-L. Ku ◽  
Han-Kwang Yang ◽  
Woo Ho Kim ◽  
Suk Young Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Familial Gastric Cancer ◽  
Gastric Cancer Patients ◽  
E Cadherin

Absence of Microsatellite Instability and Germline Mutations of E-Cadherin, APC and p53 Genes in Japanese Familial Gastric Cancer

Tumor Biology ◽  
2001 ◽  
Vol 22 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Masanobu Kusano ◽  
Hideki Kakiuchi ◽  
Mami Mihara ◽  
Fumio Itoh ◽  
Yasushi Adachi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Microsatellite Instability ◽  
Germline Mutations ◽  
Familial Gastric Cancer ◽  
P53 Genes ◽  
E Cadherin

scholarly journals Germline Mutations in MAP3K6 Are Associated with Familial Gastric Cancer

PLoS Genetics ◽  
2014 ◽  
Vol 10 (10) ◽  
pp. e1004669 ◽  
Author(s):  
Daniel Gaston ◽  
Samantha Hansford ◽  
Carla Oliveira ◽  
Mathew Nightingale ◽  
Hugo Pinheiro ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Germline Mutations ◽  
Familial Gastric Cancer

E-cadherin germline mutations and risk of gastric cancer

2002 ◽  
Vol 123 (4) ◽  
pp. 1406 ◽  
Author(s):  
Kenneth E.L. McColl ◽  
Emad El-Omar
Keyword(s):  
Gastric Cancer ◽  
Germline Mutations ◽  
E Cadherin

scholarly journals Germline mutations of the E-cadherin gene in families with inherited invasive lobular breast carcinoma but no diffuse gastric cancer

Cancer ◽  
2011 ◽  
Vol 117 (14) ◽  
pp. 3112-3117 ◽  
Author(s):  
Ze Ming Xie ◽  
Lai Sheng Li ◽  
Claire Laquet ◽  
Frédérique Penault-Llorca ◽  
Nancy Uhrhammer ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Breast Carcinoma ◽  
Germline Mutations ◽  
Diffuse Gastric Cancer ◽  
Lobular Breast Carcinoma ◽  
E Cadherin

scholarly journals CDH1/E-cadherin germline mutations in early-onset gastric cancer

2006 ◽  
Vol 43 (11) ◽  
pp. 867-872 ◽  
Author(s):  
J T Bacani ◽  
M Soares ◽  
R Zwingerman ◽  
N di Nicola ◽  
J Senz ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Onset ◽  
Germline Mutations ◽  
E Cadherin

scholarly journals E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients

2004 ◽  
Vol 40 (12) ◽  
pp. 1897-1903 ◽  
Author(s):  
Carla Oliveira ◽  
Paulo Ferreira ◽  
Sérgio Nabais ◽  
Luisa Campos ◽  
Ana Ferreira ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Genetic Predisposition ◽  
Germline Mutations ◽  
Gastric Cancer Patients ◽  
E Cadherin

Screening E-Cadherin Germline Mutations in Italian Patients with Familial Diffuse Gastric Cancer: An Analysis in the District of Urbino, Region Marche, Central Italy

2003 ◽  
Vol 89 (3) ◽  
pp. 255-258 ◽  
Author(s):  
Francesco Graziano ◽  
Anna Maria Ruzzo ◽  
Italo Bearzi ◽  
Enrica Testa ◽  
Vittorio Lai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Susceptibility ◽  
Central Italy ◽  
Germline Mutations ◽  
Pedigree Analysis ◽  
Hereditary Diffuse Gastric Cancer ◽  
Diffuse Gastric Cancer ◽  
Cancer Syndrome ◽  
Standard Polymerase Chain Reaction ◽  
E Cadherin

Aims & Background Hereditary diffuse gastric cancer is a recently defined cancer syndrome caused by inactivating, heterozygous germline mutations in the E-cadherin gene (CDH1). To date, 16 truncating germline CDH1 mutations have been described in hereditary diffuse gastric cancer families in different ethnic groups, but so far, no investigation has been addressed to Italian patients. In the District of Urbino, Region Marche, Central Italy, gastric cancer is the most common tumor in men and it is the second in women after breast cancer. In this area, we investigated CDH1 mutations in patients who fulfilled the hereditary diffuse gastric cancer criteria. Material and Methods Consecutive patients with diffuse gastric cancer were considered eligible for the study. After pedigree analysis, patients who met the International Gastric Cancer Linkage Consortium criteria were studied for CDH1 mutations. After blood samples collection and DNA extraction, standard polymerase chain reaction and sequencing techniques were used for CDH1 analysis. Results In a study population of 98 patients with diffuse gastric cancer, 11 patients (11%) showed familial clustering and 3 of them met the International Gastric Cancer Linkage Consortium criteria for hereditary diffuse gastric cancer. None of the 3 patients showed inactivating germline mutation in CDH1. Conclusions According to recent studies, the frequency of CDH1 inactivating germline mutations in patients who fulfil the hereditary diffuse gastric cancer criteria may be lower than that reported in early investigations. The results of the present study in a population of Italian patients seem to confirm these data. It is likely that unidentified mutations in CDH1 or other involved genes contribute to diffuse gastric cancer susceptibility.

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