scholarly journals Germline mutations of E-cadherin gene in Korean familial gastric cancer patients

1999 ◽  
Vol 44 (3) ◽  
pp. 177-180 ◽  
Author(s):  
Kyong-Ah Yoon ◽  
J.-L. Ku ◽  
Han-Kwang Yang ◽  
Woo Ho Kim ◽  
Suk Young Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Familial Gastric Cancer ◽  
Gastric Cancer Patients ◽  
E Cadherin

scholarly journals E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients

2004 ◽  
Vol 40 (12) ◽  
pp. 1897-1903 ◽  
Author(s):  
Carla Oliveira ◽  
Paulo Ferreira ◽  
Sérgio Nabais ◽  
Luisa Campos ◽  
Ana Ferreira ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Genetic Predisposition ◽  
Germline Mutations ◽  
Gastric Cancer Patients ◽  
E Cadherin

scholarly journals Somatic and germline mutations of Chinese gastric cancer patients

2018 ◽  
Vol 29 ◽  
pp. viii52-viii53
Author(s):  
Y. Wang ◽  
W. Gu ◽  
Y. Zhang ◽  
K. Li ◽  
Z. Niu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Gastric Cancer Patients

scholarly journals A Registry Program for Familial Gastric Cancer Patients Referred to Cancer Institute of Iran

2014 ◽  
Vol 15 (5) ◽  
pp. 2141-2144 ◽  
Author(s):  
Mehrnoosh Etemadi ◽  
Mandana Pourian ◽  
Asyeh Shakib ◽  
Tayebeh Sabokbar ◽  
Vahideh Peyghanbari ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Familial Gastric Cancer ◽  
Gastric Cancer Patients

Influence of age on soluble E-cadherin serum levels prevents its utility as a disease marker in gastric cancer patients

2008 ◽  
Vol 43 (6) ◽  
pp. 765-766 ◽  
Author(s):  
Corrado Pedrazzani ◽  
Stefano Caruso ◽  
Giovanni Corso ◽  
Daniele Marrelli ◽  
Alessandro Neri ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Disease Marker ◽  
Gastric Cancer Patients ◽  
E Cadherin

E-cadherin germline mutations in familial gastric cancer

Nature ◽  
10.1038/32918 ◽  
1998 ◽  
Vol 392 (6674) ◽  
pp. 402-405 ◽  
Author(s):  
Parry Guilford ◽  
Justin Hopkins ◽  
James Harraway ◽  
Maybelle McLeod ◽  
Ngahiraka McLeod ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Germline Mutations ◽  
Familial Gastric Cancer ◽  
E Cadherin

scholarly journals Germline mutations and polymorphic variants inMMR,E-cadherin andMYH genes associated with familial gastric cancer in Jiangsu of China

2006 ◽  
Vol 119 (11) ◽  
pp. 2592-2596 ◽  
Author(s):  
Yuanying Zhang ◽  
Xiaorong Liu ◽  
Yimei Fan ◽  
Jianhua Ding ◽  
Ailing Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Germline Mutations ◽  
Familial Gastric Cancer ◽  
Polymorphic Variants ◽  
E Cadherin

scholarly journals Prevalence of deleterious ATM germline mutations in gastric cancer patients

Oncotarget ◽  
2015 ◽  
Vol 6 (38) ◽  
pp. 40953-40958 ◽  
Author(s):  
Dong-Sheng Huang ◽  
Hou-Quan Tao ◽  
Xu-Jun He ◽  
Ming Long ◽  
Sheng Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Gastric Cancer Patients

scholarly journals Loss ofLLGL1Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Alexander Desuki ◽  
Frank Staib ◽  
Ines Gockel ◽  
Markus Moehler ◽  
Hauke Lang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Cell Lines ◽  
Gastric Cancer Cell ◽  
Cellular Adhesion ◽  
Peritoneal Metastases ◽  
Diffuse Gastric Cancer ◽  
Gastric Cancer Patients ◽  
E Cadherin

Background. Loss ofLLGL1has been associated with loss of cellular adhesion and dissemination of cells from colorectal cancer and malignant melanoma. Regulation and relevance ofLLGL1were analyzed in gastric cancer patients with lymphatic and distant dissemination. Furthermore,LLGL1expression was analyzed in relation to the cellular adhesion proteinE-cadherin.Methods.LLGL1andE-cadherintranscription levels were evaluated in 56 gastric cancer patients and five gastric cancer cell lines. IHC staining forLLGL1was performed on 39 gastric cancer specimens.LLGL1was stably transfected intoLLGL1negative gastric cancer cell line SNU16 (del(17) (p11.2)) for functionalin vitroassays and a xenograft bioassay.Results. Gastric cancer specimens and cell lines displayedLLGL1andE-cadherinexpression levels with variable intensity. In gastric mucosa,LLGL1exhibited weak cytoplasmic and strong cortical staining. Loss ofLLGL1expression occurred in 65% of gastric cancers and significantly correlated with loss ofE-cadherinexpression (P=0.00009). Loss ofLLGL1expression was associated with the diffuse type of gastric cancer (P=0.029) with peritoneal carcinomatosis (M1; P=0.006) and with female gender (P=0.017). Stable reexpression ofLLGL1in SNU16 cells significantly increased both plastic surface adhesion and extracellular matrix proteins laminin and fibronectin, but had no impact onin vitroproliferation, apoptosis, or invasion or onin vivoproliferation or differentiation in our xenograft bioassay.Conclusion.LLGL1is coexpressed withE-cadherin.Loss of expression of either protein is associated with diffuse gastric cancer and peritoneal metastases.LLGL1does not impact on proliferation or epithelial-mesenchymal transition (EMT) rather increasing cellular adhesion.

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