Immunology: T-cell receptor: gamma gene product surfaces

Nature ◽  
1986 ◽  
Vol 322 (6075) ◽  
pp. 110-111 ◽  
Author(s):  
Miranda Robertson
Keyword(s):  
T Cell ◽  
Gene Product ◽  
T Cell Receptor ◽  
Cell Receptor

scholarly journals Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire.

1991 ◽  
Vol 174 (3) ◽  
pp. 639-648 ◽  
Author(s):  
H DerSimonian ◽  
H Band ◽  
M B Brenner
Keyword(s):  
T Cells ◽  
T Cell ◽  
Gene Product ◽  
T Cell Receptor ◽  
Cd8 T Cells ◽  
Peripheral Blood ◽  
Cell Receptor ◽  
Class I ◽  
Class I Mhc ◽  
Alpha Gene

The T cell receptor repertoire has a potential for vast diversity. However, this diversity is limited by the fact that the majority of thymocytes die as the repertoire is shaped by positive and negative selection events during development. Such thymic selection affecting TCR V beta gene segment usage has been demonstrated in the mouse. However, similar data has not been forthcoming in man, and little is known about the role of the TCR alpha chain in antigen/major histocompatibility complex (MHC) recognition in any species. Here, we used a monoclonal antibody recognizing the TCR V alpha 12.1 gene product to assess the expression of this gene in the peripheral blood of man. In most individuals tested, the percentage of cells expressing V alpha 12.1 was significantly higher in CD8+ T cells than in CD4+ T cells. That the V alpha gene product itself was responsible for this increased expression in CD8+ T cells was underscored by the lack of substantial skewing of V beta usage in the V alpha 12.1-bearing T cells. Moreover, the skewed expression of V alpha 12.1 was already present at birth, indicating that it was likely to be due to a developmental process rather than the result of exposure to environmental antigens. Based on the established role for CD8 in binding to class I MHC molecules, we suggest that increased expression of V alpha 12.1 on CD8+ T cells points to a role for TCR's using V alpha 12.1 in class I MHC/Ag recognition. These results indicate that V alpha gene usage in the peripheral blood of man is not random, and they support a role for V alpha as a participant in the self-MHC recognition process that shapes the TCR repertoire.

scholarly journals HIV induces deletion of T cell receptor variable gene product-specific T cells

2008 ◽  
Vol 94 (1) ◽  
pp. 17-20 ◽  
Author(s):  
A. S. BANSAL ◽  
L. M. GREEN ◽  
S. H. KHOO ◽  
R. S. H. PUMPHREY ◽  
M. R. HAENEY ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Gene Product ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Variable Gene

SMAR1, a Novel, Alternatively Spliced Gene Product, Binds the Scaffold/Matrix-Associated Region at the T Cell Receptor β Locus

Genomics ◽  
2000 ◽  
Vol 68 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Samit Chattopadhyay ◽  
Ruchika Kaul ◽  
Alan Charest ◽  
David Housman ◽  
Jianzhu Chen
Keyword(s):  
T Cell ◽  
Gene Product ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Alternatively Spliced

Human CD3+4−8−WT31−T lymphocyte expressing the putative T cell receptor γ-gene product. A limiting dilution and clonal analysis

1987 ◽  
Vol 17 (9) ◽  
pp. 1229-1234 ◽  
Author(s):  
Lorenzo Moretta ◽  
Daniela Pende ◽  
Cristina Bottino ◽  
Nicola Migone ◽  
Ermanno Ciccone ◽  
...  
Keyword(s):  
T Cell ◽  
Gene Product ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Cell Receptor ◽  
Clonal Analysis ◽  
Limiting Dilution

scholarly journals Acute leukemia expressing the gamma gene product of the putative second T cell receptor.

1987 ◽  
Vol 79 (4) ◽  
pp. 1281-1284 ◽  
Author(s):  
R González-Sarmiento ◽  
T W LeBien ◽  
J G Bradley ◽  
J M Greenberg ◽  
J G Seidman ◽  
...  
Keyword(s):  
T Cell ◽  
Acute Leukemia ◽  
Gene Product ◽  
T Cell Receptor ◽  
Cell Receptor

Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product

2001 ◽  
Vol 13 (5) ◽  
pp. 345-352 ◽  
Author(s):  
Thomas Hinz ◽  
Sven Flindt ◽  
Antje Marx ◽  
Ottmar Janssen ◽  
Dieter Kabelitz
Keyword(s):  
Protein Synthesis ◽  
T Cell ◽  
Gene Product ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Inhibition Of Protein Synthesis
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