Human CD3+4−8−WT31−T lymphocyte expressing the putative T cell receptor γ-gene product. A limiting dilution and clonal analysis

1987 ◽  
Vol 17 (9) ◽  
pp. 1229-1234 ◽  
Author(s):  
Lorenzo Moretta ◽  
Daniela Pende ◽  
Cristina Bottino ◽  
Nicola Migone ◽  
Ermanno Ciccone ◽  
...  
Keyword(s):  
T Cell ◽  
Gene Product ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Cell Receptor ◽  
Clonal Analysis ◽  
Limiting Dilution

T-cell receptor usage in T lymphocyte clones specifically recognizing human melanoma

1993 ◽  
Vol 3 (1) ◽  
pp. 26
Author(s):  
M. Sensi ◽  
S. Salvi ◽  
C. Castelli ◽  
G. Nicolini ◽  
A. Anichini ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Cell Receptor ◽  
Human Melanoma ◽  
Receptor Usage

scholarly journals Irradiation-Mediated Rescue of T Cell–Specific V(D)j Recombination and Thymocyte Differentiation in Severe Combined Immunodeficient Mice by Bone Marrow Cells

1999 ◽  
Vol 190 (9) ◽  
pp. 1257-1262 ◽  
Author(s):  
Chiyu Wang ◽  
Molly A. Bogue ◽  
Jonathan M. Levitt ◽  
David B. Roth
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Bone Marrow Cells ◽  
Cell Lineage ◽  
Cell Receptor ◽  
Immunodeficient Mice ◽  
Thymocyte Differentiation ◽  
Marrow Cells

In SCID (severe combined immunodeficient) mice, proper assembly of immunoglobulin and T cell receptor (TCR) genes is blocked by defective V(D)J recombination so that B and T lymphocyte differentiation is arrested at an early precursor stage. Treating the mice with gamma irradiation rescues V(D)J rearrangement at multiple TCR loci, promotes limited thymocyte differentiation, and induces thymic lymphomas. These effects are not observed in the B cell lineage. Current models postulate that irradiation affects intrathymic T cell precursors. Surprisingly, we found that transfer of irradiated SCID bone marrow cells to unirradiated host animals rescues both TCR rearrangements and thymocyte differentiation. These data indicate that irradiation affects precursor cells at an earlier stage of differentiation than was previously thought and suggest new models for the mechanism of irradiation rescue.

Immunodeficiency with low expression of the T cell receptor/CD3 complex. Effect on T lymphocyte activation

1991 ◽  
Vol 21 (7) ◽  
pp. 1641-1647 ◽  
Author(s):  
Françoise Le Deist ◽  
Gabriela Thoenes ◽  
José Corado ◽  
Barbara Lisowska-Grospierre ◽  
Alain Fischer
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Lymphocyte Activation ◽  
Cell Receptor ◽  
Complex Effect ◽  
T Lymphocyte Activation ◽  
Low Expression

Immunology: T-cell receptor: gamma gene product surfaces

Nature ◽  
1986 ◽  
Vol 322 (6075) ◽  
pp. 110-111 ◽  
Author(s):  
Miranda Robertson
Keyword(s):  
T Cell ◽  
Gene Product ◽  
T Cell Receptor ◽  
Cell Receptor

T cell receptor Vβ repertoire of the antigen specific CD8 T lymphocyte subset of HIV infected children

AIDS ◽  
2002 ◽  
Vol 16 (11) ◽  
pp. 1459-1465 ◽  
Author(s):  
Thomas W. McCloskey ◽  
Viraga Haridas ◽  
Rajendra Pahwa ◽  
Savita Pahwa
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Cell Receptor ◽  
Lymphocyte Subset ◽  
Cd8 T Lymphocyte ◽  
T Cell Receptor Vβ ◽  
T Lymphocyte Subset

scholarly journals T-cell receptor Vβ repertoire of CD8+ T-lymphocyte subpopulations in cutaneous leishmaniasis patients from the state of Rio de Janeiro, Brazil

2015 ◽  
Vol 110 (5) ◽  
pp. 596-605 ◽  
Author(s):  
Raquel Ferraz ◽  
Clarissa Ferreira Cunha ◽  
Maria Inês Pimentel ◽  
Marcelo Rosandiski Lyra ◽  
Armando Oliveira Schubach ◽  
...  
Keyword(s):  
T Cell ◽  
Cutaneous Leishmaniasis ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Cell Receptor ◽  
Lymphocyte Subpopulations ◽  
The State ◽  
T Lymphocyte Subpopulations ◽  
Cd8 T Lymphocyte ◽  
T Cell Receptor Vβ

scholarly journals Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development

2004 ◽  
Vol 199 (5) ◽  
pp. 607-615 ◽  
Author(s):  
Christine Borowski ◽  
Xiaoyan Li ◽  
Iannis Aifantis ◽  
Fotini Gounari ◽  
Harald von Boehmer
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
T Lymphocyte ◽  
Developmental Stages ◽  
Cell Receptor ◽  
Unique Function ◽  
Membrane Rafts ◽  
Lymphocyte Development ◽  
Hybrid Molecule ◽  
A Cell

In contrast with the αβ T cell receptor (TCR), the pre-TCR spontaneously segregates to membrane rafts from where it signals in a cell-autonomous fashion. The disparate behaviors of these two receptors may stem either from differences inherent to the distinct developmental stages during which they are expressed, or from features intrinsic and unique to the receptor components themselves. Here, we express TCRα precisely at the pre-TCR checkpoint, at levels resembling those of endogenous pre-TCRα (pTα), and in the absence of endogenous pTα. Both in isolation and more dramatically when in competition with pTα, TCRα induced defective proliferation, survival, and differentiation of αβ T lymphocyte precursors, as well as impaired commitment to the αβ T lymphocyte lineage. Substitution of TCRα transmembrane and cytoplasmic domains with those of pTα generated a hybrid molecule possessing enhanced competitive abilities. We conclude that features intrinsic to the pre-TCR, which are absent in TCRα, are essential for its unique function.

Sign in / Sign up

Export Citation Format

Share Document