Chromosomal localization of a unique gene by non-autoradiographic in situ hybridization

Nature ◽  
1985 ◽  
Vol 317 (6033) ◽  
pp. 175-177 ◽  
Author(s):  
J. E. Landegent ◽  
N. Jansen in de Wal ◽  
G.-J. B. van Omment ◽  
F. Baas ◽  
J. J. M. de Vijlderi ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Chromosomal Localization ◽  
Unique Gene

scholarly journals Chromosomal localization of human genes for arylamine N-acetyltransferase

1994 ◽  
Vol 297 (3) ◽  
pp. 441-445 ◽  
Author(s):  
D Hickman ◽  
A Risch ◽  
V Buckle ◽  
N K Spurr ◽  
S J Jeremiah ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
In Situ Hybridization ◽  
Yeast Artificial Chromosome ◽  
Chromosomal Localization ◽  
Artificial Chromosome ◽  
Acetylator Phenotype ◽  
Chromosome 8 ◽  
Slow Acetylator ◽  
Human Genes

Arylamine N-acetyltransferase is encoded at two loci, AAC-1 and AAC-2, on human chromosome 8. The products of the two loci are able to catalyse N-acetylation of arylamine carcinogens, such as benzidine and other xenobiotics. AAC-2 is polymorphic and individuals carrying the slow-acetylator phenotype are more susceptible to benzidine-induced bladder cancer. We have identified yeast artificial chromosome clones encoding AAC-1 and AAC-2 and have used the cloned DNAs as fluorescent probes for in situ hybridization. The hybridization patterns allow assignment of AAC-1 and AAC-2 to chromosome 8p21.3-23.1, a region in which deletions have been associated with bladder cancer [Knowles, Shaw and Proctor (1993) Oncogene 8, 1357-1364].

Chromosomal localization of leukocyte interferon gene in the pig (Sus scrofa domestica L.) by in situ hybridization

1986 ◽  
Vol 42 (3) ◽  
pp. 129-132 ◽  
Author(s):  
M. Yerle ◽  
J. Gellin ◽  
G. Echard ◽  
F. Lefevre ◽  
M. Gillois
Keyword(s):  
In Situ Hybridization ◽  
Sus Scrofa ◽  
Chromosomal Localization ◽  
Interferon Gene

Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization

1988 ◽  
Vol 47 (1-2) ◽  
pp. 16-17 ◽  
Author(s):  
J.L. McCombs ◽  
C.T. Teng ◽  
B.T. Pentecost ◽  
V.L. Magnuson ◽  
C.M. Moore ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Chromosomal Localization

Chromosomal localization of human O6-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization

Mutagenesis ◽  
1992 ◽  
Vol 7 (1) ◽  
pp. 83-85 ◽  
Author(s):  
A.T. Natarajan ◽  
Sylvia Vermeulen ◽  
F. Darroudi ◽  
Marcus B. Valentine ◽  
Thomas P. Brent ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Dna Methyltransferase ◽  
Chromosomal Localization ◽  
Mgmt Gene ◽  
Methylguanine Dna Methyltransferase
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