The human T-cell receptor α-chain gene maps to chromosome 14

Nature ◽  
1985 ◽  
Vol 314 (6008) ◽  
pp. 273-274 ◽  
Author(s):  
M. K. L. Collins ◽  
P. N. Goodfellow ◽  
N. K. Spurr ◽  
E. Solomon ◽  
G. Tanigawa ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Chromosome 14 ◽  
Human T Cell ◽  
Α Chain ◽  
Gene Maps

scholarly journals A cluster of chromosome 11p13 translocations found via distinct D-D and D-D-J rearrangements of the human T cell receptor delta chain gene.

1988 ◽  
Vol 7 (7) ◽  
pp. 2011-2017 ◽  
Author(s):  
T. Boehm ◽  
L. Buluwela ◽  
D. Williams ◽  
L. White ◽  
T. H. Rabbitts
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Human T Cell

An (8;14)(q24;q11) translocation involving the T-cell receptor α-chain gene and theMYC oncogene 3′ region in a B-cell lymphoma

1989 ◽  
Vol 1 (1) ◽  
pp. 15-22 ◽  
Author(s):  
James K. Park ◽  
Timothy W. McKeithan ◽  
Michelle M. le Beau ◽  
Mitchell A. Bitter ◽  
Wilbur A. Franklin ◽  
...  
Keyword(s):  
T Cell ◽  
B Cell ◽  
T Cell Receptor ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cell Receptor ◽  
Chain Gene ◽  
Α Chain

The gene encoding the T-cell receptor α-chain maps close to the Np-2 locus on mouse chromosome 14

Nature ◽  
1985 ◽  
Vol 314 (6008) ◽  
pp. 271-273 ◽  
Author(s):  
Zlatko DembiĆ ◽  
Wilhelm Bannwarth ◽  
Benjamin A. Taylor ◽  
Michael Steinmetz
Keyword(s):  
T Cell ◽  
Mouse Chromosome ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chromosome 14 ◽  
Gene Encoding ◽  
Α Chain ◽  
Chain Maps

Rearranging sequence located in the intron of the human T cell receptor γ chain gene constant region

1989 ◽  
Vol 19 (4) ◽  
pp. 637-642 ◽  
Author(s):  
Zhu Chen ◽  
Pascale Loiseau ◽  
Jean Christophe Bories ◽  
Armand Bensussan ◽  
FrançOis Sigaux
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Constant Region ◽  
Human T Cell

scholarly journals T cell receptor alpha chain genes are located on chromosome 14 at 14q11-14q12 in humans.

1985 ◽  
Vol 161 (5) ◽  
pp. 1255-1260 ◽  
Author(s):  
N Caccia ◽  
G A Bruns ◽  
I R Kirsch ◽  
G F Hollis ◽  
V Bertness ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chromosome 14 ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Human T Cell ◽  
Receptor Alpha Chain ◽  
Cell Receptor Alpha

A cDNA clone encoding the alpha chain of the human T cell receptor was used in connection with somatic cell human-rodent hybrids to determine that the genes coding for the alpha chain are located on chromosome 14 in humans. In situ hybridization confirms this result and further localizes these genes to 14q11-14q12 on this chromosome. Since this region of chromosome has been shown to be nonrandomly involved in a number of T cell neoplasias, this assignment raises a number of interesting questions as to the possible involvement of the T cell receptor alpha chain genes in tumorigenesis.

scholarly journals Erratum: Isolation of an excision product of T-cell receptor α-chain gene rearrangements

Nature ◽  
1987 ◽  
Vol 327 (6121) ◽  
pp. 439-439
Author(s):  
Shinji Fujimoto ◽  
Hideo Yamagishi
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Gene Rearrangements ◽  
Α Chain

scholarly journals Promoter and enhancer elements in the rearranged alpha chain gene of the human T cell receptor.

1987 ◽  
Vol 6 (11) ◽  
pp. 3307-3312 ◽  
Author(s):  
S. Luria ◽  
G. Gross ◽  
M. Horowitz ◽  
D. Givol
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chain Gene ◽  
Alpha Chain ◽  
Human T Cell

scholarly journals Sizing of the human T cell receptor alpha locus and detection of a large deletion in the Molt-4 cell line

Blood ◽  
1988 ◽  
Vol 71 (6) ◽  
pp. 1744-1747 ◽  
Author(s):  
MS Roth ◽  
FS Collins ◽  
D Ginsburg
Keyword(s):  
T Cell ◽  
Cell Line ◽  
T Cell Receptor ◽  
Mononuclear Cells ◽  
Cell Receptor ◽  
Chain Gene ◽  
Normal Peripheral Blood ◽  
Receptor Alpha ◽  
Human T Cell ◽  
Cell Receptor Alpha

Abstract The human T cell receptor alpha (TCR-alpha) chain gene consists of discontinuous DNA segments encoding multiple variable (V), multiple joining (J), and one constant (C) region. Unlike other immunoglobulin or TCR genes, however, the TCR-alpha locus exhibits an unusual dispersal of J segments that occupy a region of greater than 50 kilobases (kb) upstream of the C region, with the exact size still unknown. We report here the study of the TCR-alpha genetic locus by using pulsed-field gel electrophoresis (PFGE), which permits the separation of large DNA fragments. Analysis of DNA prepared from normal peripheral blood mononuclear cells, human endothelial cells, and a B cell line demonstrates that both V and C sequences are contained within a single 400-kb SfiI restriction fragment. PFGE analysis of the T cell line Molt 4 suggests a greater than 600-kb deletion involving the TCR- alpha gene.

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