scholarly journals ‘G1 rate’ model of cell cycle—a realistic alternative to ‘transition probability’? (reply)

Nature ◽  
1981 ◽  
Vol 293 (5834) ◽  
pp. 681-681
Author(s):  
LAROY N. CASTOR
Keyword(s):  
Cell Cycle ◽  
Transition Probability ◽  
Rate Model

‘G1 rate’ model of cell cycle—a realistic alternative to ‘transition probability’?

Nature ◽  
1981 ◽  
Vol 293 (5834) ◽  
pp. 680-681 ◽  
Author(s):  
R. F. BROOKS ◽  
J. A. SMITH ◽  
D. C. BENNETT ◽  
K. M. V. RICHMOND
Keyword(s):  
Cell Cycle ◽  
Transition Probability ◽  
Rate Model

scholarly journals Cell Cycle Commitment and the Origins of Cell Cycle Variability

2021 ◽  
Vol 9 ◽  
Author(s):  
Robert F. Brooks
Keyword(s):  
Cell Cycle ◽  
Dynamic Behavior ◽  
Transition Probability ◽  
Molecular Networks ◽  
Probability Models ◽  
Clonal Population ◽  
Restriction Point ◽  
The Relationship ◽  
Mitogenic Signal

Exit of cells from quiescence following mitogenic stimulation is highly asynchronous, and there is a great deal of heterogeneity in the response. Even in a single, clonal population, some cells re-enter the cell cycle after a sub-optimal mitogenic signal while other, seemingly identical cells, do not, though they remain capable of responding to a higher level of stimulus. This review will consider the origins of this variability and heterogeneity, both in cells re-entering the cycle from quiescence and in the context of commitment decisions in continuously cycling populations. Particular attention will be paid to the role of two interacting molecular networks, namely the RB-E2F and APC/CCDH1 “switches.” These networks have the property of bistability and it seems likely that they are responsible for dynamic behavior previously described kinetically by Transition Probability models of the cell cycle. The relationship between these switches and the so-called Restriction Point of the cell cycle will also be considered.

Transition probability and cell-cycle initiation in yeast

Nature ◽  
1977 ◽  
Vol 267 (5612) ◽  
pp. 647-648 ◽  
Author(s):  
A. E. WHEALS
Keyword(s):  
Cell Cycle ◽  
Transition Probability

Transition probability and cell-cycle initiation in yeast (reply)

Nature ◽  
1977 ◽  
Vol 267 (5612) ◽  
pp. 648-649 ◽  
Author(s):  
B. SHILO ◽  
VARDA SHILO ◽  
G. SIMCHEN
Keyword(s):  
Cell Cycle ◽  
Transition Probability
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