A G1 rate model accounts for cell-cycle kinetics attributed to ‘transition probability’

Nature ◽  
1980 ◽  
Vol 287 (5785) ◽  
pp. 857-859 ◽  
Author(s):  
LaRoy N. Castor
Keyword(s):  
Cell Cycle ◽  
Transition Probability ◽  
Rate Model ◽  
Cell Cycle Kinetics

‘G1 rate’ model of cell cycle—a realistic alternative to ‘transition probability’?

Nature ◽  
1981 ◽  
Vol 293 (5834) ◽  
pp. 680-681 ◽  
Author(s):  
R. F. BROOKS ◽  
J. A. SMITH ◽  
D. C. BENNETT ◽  
K. M. V. RICHMOND
Keyword(s):  
Cell Cycle ◽  
Transition Probability ◽  
Rate Model

Sources of variation in intermitotic time and their relation to cell cycle kinetics

1981 ◽  
Vol 93 (4) ◽  
pp. 1037-1045 ◽  
Author(s):  
E.J.J. van Zoelen ◽  
P.T. van der Saag ◽  
S.W. de Laat
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Kinetics ◽  
Sources Of Variation

Demonstration of cell cycle kinetics in thyroid primary culture by immunostaining of proliferating cell nuclear antigen: differences in cyclic AMP-dependent and -independent mitogenic stimulations

1993 ◽  
Vol 105 (1) ◽  
pp. 69-80 ◽  
Author(s):  
M. Baptist ◽  
J.E. Dumont ◽  
P.P. Roger
Keyword(s):  
Cell Cycle ◽  
Dna Synthesis ◽  
Primary Culture ◽  
Proliferating Cell Nuclear Antigen ◽  
Cell Cycle Progression ◽  
Nuclear Antigen ◽  
Major Influence ◽  
Cell Cycle Kinetics ◽  
Experimental Conditions ◽  
Proliferating Cell

In this study, experimental conditions are described that allowed us to follow the fate of the DNA polymerase delta-associated proliferating cell nuclear antigen (PCNA), by immunolabeling during the overall cell cycle. Differences in subcellular localization or the presence of PCNA allowed us to identify each phase of the cell cycle. Using these cell cycle markers in dog thyroid epithelial cells in primary culture, we found unexpected differences in cell cycle kinetics, in response to stimulations through cAMP-dependent and cAMP-independent pathways. These provide a new dimension to the view that the two pathways are largely separate, but co-operate on DNA synthesis initiation. More precisely, thyrotropin (TSH), acting via cAMP, exerts a potent triggering effect on DNA synthesis, associated with a precocious induction of PCNA appearance. This constitutes the major influence of TSH (cAMP) in determining cell cycle progression, which is only partly moderated by TSH-dependent lengthening of S- and G2-phases.

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