Brown adipose tissue and diet-induced thermogenesis

Nature ◽  
1981 ◽  
Vol 289 (5799) ◽  
pp. 699-699 ◽  
Author(s):  
G. R. HERVEY ◽  
G. TOBIN
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Diet Induced Thermogenesis

CNS origins of the sympathetic nervous system outflow to brown adipose tissue

1999 ◽  
Vol 276 (6) ◽  
pp. R1569-R1578 ◽  
Author(s):  
Maryam Bamshad ◽  
C. Kay Song ◽  
Timothy J. Bartness
Keyword(s):  
Nervous System ◽  
Adipose Tissue ◽  
Sympathetic Nervous System ◽  
Brown Adipose Tissue ◽  
Pseudorabies Virus ◽  
Critical Role ◽  
Hypothalamic Nucleus ◽  
Brown Adipose ◽  
Sympathetic Nervous ◽  
Diet Induced Thermogenesis

Brown adipose tissue (BAT) plays a critical role in cold- and diet-induced thermogenesis. Although BAT is densely innervated by the sympathetic nervous system (SNS), little is known about the central nervous system (CNS) origins of this innervation. The purpose of the present experiment was to determine the neuroanatomic chain of functionally connected neurons from the CNS to BAT. A transneuronal viral tract tracer, Bartha’s K strain of the pseudorabies virus (PRV), was injected into the interscapular BAT of Siberian hamsters. The animals were killed 4 and 6 days postinjection, and the infected neurons were visualized by immunocytochemistry. PRV-infected neurons were found in the spinal cord, brain stem, midbrain, and forebrain. The intensity of labeled neurons in the forebrain varied from heavy infections in the medial preoptic area and paraventricular hypothalamic nucleus to few infections in the ventromedial hypothalamic nucleus, with moderate infections in the suprachiasmatic and lateral hypothalamic nuclei. These results define the SNS outflow from the brain to BAT for the first time in any species.

Effect of glucose and other hexoses on efferent discharges of brown adipose tissue nerves

1986 ◽  
Vol 251 (2) ◽  
pp. R240-R242 ◽  
Author(s):  
A. Niijima
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Sympathetic Nerves ◽  
Nerve Activity ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
Diet Induced Thermogenesis ◽  
Effect Of Glucose

The activity of sympathetic nerves innervating interscapular brown adipose tissue of the rat was recorded. Intravenous administrations of glucose (100-300 mg/kg) enhanced the nerve activity. However, mannose, fructose, or galactose (300 mg/kg) showed no effect, suggesting the response is related to diet-induced thermogenesis in the brown adipose tissue.

Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent

2020 ◽  
Vol 472 (3) ◽  
pp. 405-417
Author(s):  
Nikola Habek ◽  
Marina Dobrivojević Radmilović ◽  
Milan Kordić ◽  
Katarina Ilić ◽  
Sandra Grgić ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Diet Induced Thermogenesis

Relation of Diet-Induced Thermogenesis to Brown Adipose Tissue Activity in Healthy Men

2020 ◽  
Author(s):  
Rahel Catherina Loeliger ◽  
Claudia Irene Maushart ◽  
Gani Gashi ◽  
Jaël Rut Senn ◽  
Martina Felder ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Oral Glucose ◽  
Oral Glucose Load ◽  
Glucose Load ◽  
Healthy Men ◽  
Bat Activity ◽  
Brown Adipose ◽  
Diet Induced Thermogenesis

Objective Human brown adipose tissue (BAT) is a thermogenic tissue activated by the sympathetic nervous system in response to cold. It contributes to energy expenditure (EE) and takes up glucose and lipids from the circulation. Studies in rodents suggest that BAT contributes to the transient rise in EE after food intake, so called diet-induced thermogenesis (DIT). We investigated the relationship between human BAT activity and DIT in response to glucose intake in 17 healthy volunteers. Methods We assessed DIT, cold induced thermogenesis (CIT) and maximum BAT activity at three separate study visits within two weeks. DIT was measured by indirect calorimetry during an oral glucose tolerance-test. CIT was assessed as the difference in EE after cold exposure of two hours duration as compared to warm conditions. Maximal activity of BAT was assessed by 18F-FDG-PET/MRI after cold exposure and concomitant pharmacological stimulation with Mirabegron. Results 17 healthy men (mean age 23.4 years, mean BMI 23.2 kg/m2) participated in the study. EE increased from 1908 (±181) kcal/24 hours to 2128 (±277) kcal/24 hours (p<0.0001, +11.5%) after mild cold exposure. An oral glucose load increased EE from 1911 (±165) kcal/24 hours to 2096 (±167) kcal/24 hours at 60 minutes (p<0.0001, +9.7%). The increase in EE in response to cold was significantly associated with BAT activity (R2=0.43, p=0.004). However, DIT was not associated with BAT activity (R2=0.015, p=0.64). Conclusion DIT after an oral glucose load was not associated with stimulated 18F-FDG uptake into BAT suggesting that DIT is independent from BAT activity in humans.

Relationship of brown adipose tissue with growth and obesity differences in genetically selected mouse lines

1984 ◽  
Vol 26 (3) ◽  
pp. 339-347 ◽  
Author(s):  
A. M. Saxton ◽  
E. J. Eisen ◽  
J. M. Leatherwood
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Single Gene ◽  
Tissue Growth ◽  
Growth Patterns ◽  
High Fat ◽  
Polygenic Control ◽  
Brown Adipose ◽  
Diet Induced Thermogenesis

A recent hypothesis considers brown adipose tissue (BAT) to be an important source of diet-induced thermogenesis (DIT). In turn, DIT and thermogenesis in general are believed to be key factors in the control of obesity of laboratory rodents. This hypothesis was developed from the study of single gene mutant obese rodents. The present research tested this hypothesis in mice with polygenic control of growth and obesity, which is more characteristic of the type of genetic variation expected in human and other mammalian populations. Control and high fat diets were used to test responses of five genetically selected lines of mice showing different patterns of growth and obesity. All lines deposited more fat on the high fat diet, but the most obese line showed the largest increase in BAT and the lipid-free dry (LFD) component of BAT. Use of LFD per unit body weight gave results which supported the hypothesis being tested, but it was argued that this measure is misleading. When brown and white adipose tissue growth relative to body weight were examined, 2 of the 10 line – diet groups showed alterations in BAT growth patterns. However, it was concluded that BAT, if involved at all, was not a major factor in growth and obesity differences.Key words: obesity, polygenes, adipose tissue, quantitative inheritance, mouse.

scholarly journals Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans

2016 ◽  
Vol 40 (11) ◽  
pp. 1655-1661 ◽  
Author(s):  
M Hibi ◽  
S Oishi ◽  
M Matsushita ◽  
T Yoneshiro ◽  
T Yamaguchi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Body Fat ◽  
Whole Body ◽  
Fat Utilization ◽  
Healthy Humans ◽  
Brown Adipose ◽  
Diet Induced Thermogenesis

Sympathoadrenal system and regulation of thermogenesis

1984 ◽  
Vol 247 (2) ◽  
pp. E181-E189 ◽  
Author(s):  
L. Landsberg ◽  
M. E. Saville ◽  
J. B. Young
Keyword(s):  
Adipose Tissue ◽  
Dietary Intake ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Critical Role ◽  
Interscapular Brown Adipose Tissue ◽  
Norepinephrine Turnover ◽  
Brown Adipose ◽  
Adult Humans ◽  
Diet Induced Thermogenesis

The sympathetic nervous system (SNS) plays a critical role in the regulation of mammalian thermogenic responses to cold exposure and dietary intake. Catecholamine-stimulated thermogenesis is mediated by the beta-adrenergic receptor. In the rat brown adipose tissue is the major site of metabolic heat production in response to both cold (nonshivering thermogenesis) and diet (diet-induced thermogenesis). Measurements of norepinephrine turnover rate in interscapular brown adipose tissue of the rat demonstrate increased sympathetic activity in response to both cold exposure and overfeeding. In adult humans, a physiologically significant role for brown adipose tissue has not been established but cannot be excluded. It appears likely that dietary changes in SNS activity are related, at least in part, to the changes in metabolic rate that occur in association with changes in dietary intake.

Sign in / Sign up

Export Citation Format

Share Document