Amino acid sequence changes in the haemagglutinin of A/Hong Kong (H3N2) influenza virus during the period 1968–77

Nature ◽  
1980 ◽  
Vol 283 (5746) ◽  
pp. 454-457 ◽  
Author(s):  
W. G. Laver ◽  
G. M. Air ◽  
T. A. Dopheide ◽  
C. W. Ward
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
H3n2 Influenza ◽  
H3n2 Influenza Virus

scholarly journals Effect of receptor specificity of A/Hong Kong/1/68 (H3N2) influenza virus variants on replication and transmission in pigs

2012 ◽  
Vol 7 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Sjouke Van Poucke ◽  
Jennifer Uhlendorff ◽  
Zhongfang Wang ◽  
Veerle Billiau ◽  
John Nicholls ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Receptor Specificity ◽  
H3n2 Influenza ◽  
H3n2 Influenza Virus

scholarly journals Prevalence of Hong Kong (H3N2) influenza virus-antibody in swine.

1985 ◽  
Vol 47 (4) ◽  
pp. 633-638 ◽  
Author(s):  
Toshihiro HIRANO ◽  
Yoshitaka OGAWA ◽  
Hitoshi GOTO ◽  
Kiheiji SHIMIZU ◽  
Shinichi NORO ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Virus Antibody ◽  
H3n2 Influenza ◽  
H3n2 Influenza Virus

scholarly journals Amino acid sequence and oligosaccharide distribution of the haemagglutinin from an early Hong Kong influenza virus variant A/Aichi/2/68 (X-31)

1981 ◽  
Vol 193 (3) ◽  
pp. 953-962 ◽  
Author(s):  
C W Ward ◽  
T A Dopheide
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Peptide Sequencing ◽  
Amino Acid Sequences ◽  
Hydrophobic Region ◽  
Virus Variant ◽  
The Individual ◽  
Polypeptide Chains

The amino acid sequence and oligosaccharide distribution for the haemagglutinin from the early Hong Kong influenza virus A/Aichi/2/68 (X-31) was investigated. The two polypeptide chains, HA1 and HA2, were fragmented by CNBr and enzymic digestion, and the amino acid sequence of each small peptide was deduced by comparing its chromatographic behaviour, electrophoretic mobility, amino acid composition and N-terminus with that of the corresponding peptide of the haemagglutinin of known structure from the influenza-virus variant A/Memphis/102/72. Those peptides in which changes were detected were sequenced fully. The complete amino acid sequence of the haemagglutinin HA1 chain (328 residues) and 188 of the 221 residues of the HA2 chain were established by this approach, and revealed only twelve differences between the amino acid sequences of variant-A/Aichi/68 and -A/Memphis/72 haemagglutinins. These occurred at positions 2, 3, 122, 144, 155, 158, 188, 207, 242 and 275 in the HA1 chain and 150 and 216 in the HA2 chain. The highly aggregated hydrophobic region (residues 180-121) near the C-terminal end of the HA2 chain was not resolved by peptide sequencing. The oligosaccharide distribution in variant-A/Aichi/68 haemagglutinin was identical with that found in that of A/Memphis/72, with sugar units attached at asparagine residues 8, 22 38, 81, 165 and 285 in the HA1 chain and 154 on the HA2 chain. The monosaccharide compositions of the individual carbohydrate units on variant-A/Aichi/68 haemagglutinin differed from those of the corresponding units in variant-A/Memphis/72 haemagglutinin, and evidence was found for heterogeneity in the oligosaccharide units attached at single glycosylation sites.

scholarly journals Evolution of the Hong Kong influenza A sub-type. Structural relationships between the haemagglutinin from A/duck/Ukraine/1/63 (Hav 7) and the Hong Kong (H3) haemagglutinins

1981 ◽  
Vol 195 (1) ◽  
pp. 337-340 ◽  
Author(s):  
C W Ward ◽  
T A Dopheide
Keyword(s):  
Influenza Virus ◽  
Hong Kong ◽  
Amino Acid ◽  
Sequence Analysis ◽  
Amino Acid Sequence ◽  
Influenza A ◽  
Antigenic Drift ◽  
Amino Acid Sequence Analysis ◽  
Structural Relationships ◽  
The Relationship

The relationship between the haemagglutinin from the influenza virus A/duck/Ukraine/1/63 (Hav 7) and the human Hong Kong variants (H3) has been investigated. Amino-acid-sequence analysis shows that the Hav 7 haemagglutinin closely resembles the 1968 human H3 haemagglutinin in structure. However, the number of amino-acid-sequence differences (23) suggest that the Hong Kong haemagglutinin gene did not come directly from A/duck/Ukraine/1/63 but from a virus derived from it by antigenic drift during the period 1963-1968.

Pathology in dogs with experimental canine H3N2 influenza virus infection

2010 ◽  
Vol 88 (3) ◽  
pp. 523-527 ◽  
Author(s):  
K. Jung ◽  
C.S. Lee ◽  
B.K. Kang ◽  
B.K. Park ◽  
J.S. Oh ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
H3n2 Influenza ◽  
Experimental Canine ◽  
H3n2 Influenza Virus

scholarly journals H3N2 Influenza Virus Transmission from Swine to Turkeys, United States

2004 ◽  
Vol 10 (12) ◽  
pp. 2156-2160 ◽  
Author(s):  
Young K. Choi ◽  
Jee H. Lee ◽  
Gene Erickson ◽  
Sagar M. Goyal ◽  
Han S. Joo ◽  
...  
Keyword(s):  
United States ◽  
Influenza Virus ◽  
Virus Transmission ◽  
H3n2 Influenza ◽  
H3n2 Influenza Virus
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