Release of vasoactive intestinal polypeptide in mast cells by histamine liberators

Nature ◽  
1978 ◽  
Vol 275 (5681) ◽  
pp. 661-662 ◽  
Author(s):  
ERNEST CUTZ ◽  
WILSON CHAN ◽  
NORMAN S. TRACK ◽  
ANDRES GOTH ◽  
SAMI I. SAID
Keyword(s):  
Mast Cells ◽  
Vasoactive Intestinal Polypeptide ◽  
Histamine Liberators ◽  
Intestinal Polypeptide

scholarly journals Vasoactive Intestinal Polypeptide and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome

2017 ◽  
Vol 153 (4) ◽  
pp. 948-960.e3 ◽  
Author(s):  
Olga Bednarska ◽  
Susanna A. Walter ◽  
Maite Casado-Bedmar ◽  
Magnus Ström ◽  
Eloísa Salvo-Romero ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Vasoactive Intestinal Polypeptide ◽  
Colonic Bacteria ◽  
Irritable Bowel ◽  
Intestinal Polypeptide

Innervation of papilla vallata in diabetic rats

2013 ◽  
Vol 154 (12) ◽  
pp. 443-448 ◽  
Author(s):  
Helén Hevér ◽  
Károly Altdorfer ◽  
Tivadar Zelles ◽  
Bayarchimeg Batbayar ◽  
Erzsébet Fehér
Keyword(s):  
Mast Cells ◽  
Substance P ◽  
Neuropeptide Y ◽  
Vasoactive Intestinal Polypeptide ◽  
Insulin Treatment ◽  
Diabetic Rats ◽  
Taste Buds ◽  
Nerve Terminals ◽  
Nerve Fibres ◽  
Intestinal Polypeptide

Introduction: Abnormal sensations such as pain and impairment of taste are symptoms of approximately 10% of patients having diabetes mellitus. Aim: The aim of the study was to investigate and quantify the different neuropeptide containing nerve fibres in the vallate papilla of the diabetic rat. Methods: Immunohistochemical methods were used to study the changes of the number of different neuropeptide containing nerve terminals located in the vallate papillae in diabetic rats. Diabetes was induced in the rats with streptozotocin. Results: Two weeks after streptozotocin treatment the number of the substance P, galanin, vasoactive intestinal polypeptide and neuropeptide Y immunoreactive nerve terminals was significantly increased (p<0.05) in the tunica mucosa of the tongue. The number of the lymphocytes and mast cells was also increased significantly. Some of the immunoreactive nerve terminals were located in the lingual epithelium both intragemmally and extragemmally and were seen to comprise dense bundles in the lamina propria just beneath the epithelium. No taste cells were immunoreactive for any of the investigated peptides. Vasoactive intestinal polypeptide and neuropeptide Y immunoreactive nerve fibres were not detected in the taste buds. For weeks after streptozotocin administration the number of the substance P, calcitonin gene related peptide and galanin immunoreactive nerve terminals was decreased both intragemmally and intergemmally. In case of immediate insulin treatment, the number of the immunoreactive nerve terminals was similar to that of the controls, however, insulin treatment given 1 week later to diabetic rats produced a decreased number of nerve fibers. Morphometry revealed no significant difference in papilla size between the control and diabetic groups, but there were fewer taste buds (per papilla). Conclusions: Increased number of immunoreactive nerve terminals and mast cells 2 weeks after the development of diabetes was the consequence of neurogenic inflammation which might cause vasoconstriction and lesions of the oral mucosa. Taste impairment, which developed 4 weeks after streptozotocin treatment could be caused by neuropathic defects and degeneration or morphological changes in the taste buds and nerve fibres. Orv. Hetil., 2013, 154, 443–448.

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