Is digitalis inotropy associated with enhanced slow inward calcium current?

Nature ◽  
1978 ◽  
Vol 273 (5661) ◽  
pp. 389-392 ◽  
Author(s):  
R. WEINGART ◽  
R. S. KASS ◽  
R. W. TSIEN
Keyword(s):  
Calcium Current ◽  
Slow Inward Calcium Current

Effect of creatine phosphate on the slow inward calcium current, action potential, and the contractile force of frog atrium and ventricle

1979 ◽  
Vol 21 (1) ◽  
pp. 1-15 ◽  
Author(s):  
L.V. Rosenshtraukh ◽  
V.A. Saks ◽  
I.A. Yuriavichus ◽  
V.V. Nesterenko ◽  
A.I. Undrovinas ◽  
...  
Keyword(s):  
Action Potential ◽  
Calcium Current ◽  
Creatine Phosphate ◽  
Contractile Force ◽  
Current Action ◽  
Slow Inward Calcium Current ◽  
Frog Atrium

Angiotens in II blocked outward K+ current and activated slow inward calcium current in aortic single cell

1987 ◽  
Vol 19 ◽  
pp. S7-S7
Author(s):  
G BKAILY ◽  
M PEYROW ◽  
D REGOLI ◽  
A SCULPTOREANU ◽  
D JACQUES ◽  
...  
Keyword(s):  
Single Cell ◽  
Calcium Current ◽  
K Current ◽  
Slow Inward Calcium Current

A new calcium current underlying the plateau of the cardiac action potential

1984 ◽  
Vol 223 (1230) ◽  
pp. 35-48 ◽  
Keyword(s):  
Action Potential ◽  
Calcium Current ◽  
Calcium Currents ◽  
Cardiac Action Potential ◽  
Heart Cells ◽  
Threshold Potential ◽  
Cardiac Action ◽  
Ventricular Cells ◽  
Current Voltage ◽  
Slow Inward Calcium Current

A small and very slow inward calcium current has been identified in isolated single ventricular cells using TTX and Cd 2+ to block the sodium and fast calcium currents. Activation requires about 300 ms at the threshold potential of —60 mV, decreasing to 80 ms at the peak current voltage of —30 mV. Inactivation is five to ten times longer. Half steady-state activation and inactivation are at — 50 and — 45 mV respectively. The current is distinctively different in both its kinetics and pharmacology from the conventional calcium current described in single heart cells. It is proposed that it contributes significant current to help maintain a major portion of the long ventricular action potential.

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