Selective contact-dependent cell communication

Nature ◽  
1976 ◽  
Vol 264 (5588) ◽  
pp. 760-762 ◽  
Author(s):  
I. FENTIMAN ◽  
J. TAYLOR-PAPADIMITRIOU ◽  
M. STOKER
Keyword(s):  
Cell Communication ◽  
Dependent Cell

scholarly journals Gap Junction Dependent Cell Communication Is Modulated During Transdifferentiation of Mesenchymal Stem/Stromal Cells Towards Neuron-Like Cells

2020 ◽  
Vol 8 ◽  
Author(s):  
Nadine Dilger ◽  
Anna-Lena Neehus ◽  
Klaudia Grieger ◽  
Andrea Hoffmann ◽  
Max Menssen ◽  
...  
Keyword(s):  
Gap Junction ◽  
Stromal Cells ◽  
Cell Communication ◽  
Dependent Cell

scholarly journals Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Karine Frénal ◽  
Damien Jacot ◽  
Pierre-Mehdi Hammoudi ◽  
Arnault Graindorge ◽  
Bohumil Maco ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Cell Communication ◽  
Dependent Cell ◽  
Cell Cell

scholarly journals Contact area–dependent cell communication and the morphological invariance of ascidian embryogenesis

Science ◽  
2020 ◽  
Vol 369 (6500) ◽  
pp. eaar5663 ◽  
Author(s):  
Léo Guignard ◽  
Ulla-Maj Fiúza ◽  
Bruno Leggio ◽  
Julien Laussu ◽  
Emmanuel Faure ◽  
...  
Keyword(s):  
Marine Invertebrate ◽  
Cell Communication ◽  
Light Sheet ◽  
Embryonic Cell ◽  
Cell Segmentation ◽  
Asymmetric Cell Divisions ◽  
Morphogen Gradients ◽  
Cell Lineages ◽  
Genomic Divergence ◽  
Dependent Cell

Marine invertebrate ascidians display embryonic reproducibility: Their early embryonic cell lineages are considered invariant and are conserved between distantly related species, despite rapid genomic divergence. Here, we address the drivers of this reproducibility. We used light-sheet imaging and automated cell segmentation and tracking procedures to systematically quantify the behavior of individual cells every 2 minutes during Phallusia mammillata embryogenesis. Interindividual reproducibility was observed down to the area of individual cell contacts. We found tight links between the reproducibility of embryonic geometries and asymmetric cell divisions, controlled by differential sister cell inductions. We combined modeling and experimental manipulations to show that the area of contact between signaling and responding cells is a key determinant of cell communication. Our work establishes the geometric control of embryonic inductions as an alternative to classical morphogen gradients and suggests that the range of cell signaling sets the scale at which embryonic reproducibility is observed.

scholarly journals Genetic Analysis of the DrosophilaDNAprimGene: The Function of the 60-kD Primase Subunit of DNA Polymerase Opposes thefat facetsSignaling Pathway in the Developing Eye

Genetics ◽  
2000 ◽  
Vol 156 (4) ◽  
pp. 1787-1795 ◽  
Author(s):  
Xin Chen ◽  
Qinghong Li ◽  
Janice A Fischer
Keyword(s):  
Dna Polymerase ◽  
Dna Sequences ◽  
Compound Eye ◽  
Large Subunit ◽  
Cell Communication ◽  
Dna Primase ◽  
Morphological Defects ◽  
Dependent Cell ◽  
Fat Facets ◽  
Communication Pathway

AbstractThe Drosophila DNAprim gene encodes the large subunit (60 kD) of DNA primase, the part of DNA polymerase α that synthesizes RNA primers during DNA replication. The precise function of the 60-kD subunit is unknown. In a mutagenesis screen for suppressors of the fat facets (faf) mutant eye phenotype, we identified mutations in DNAprim. The faf gene encodes a deubiquitinating enzyme required specifically for patterning the compound eye. The DNA sequences of four DNAprim alleles were determined and these define essential protein domains. We show that while flies lacking DNAprim activity are lethal, flies with reduced DNAprim activity display morphological defects in their eyes, and unlike faf mutants, cell cycle abnormalities in larval eye discs. Mechanisms by which DNA primase levels might influence the faf-dependent cell communication pathway are discussed.

scholarly journals A LuxS-Dependent Cell-to-Cell Language Regulates Social Behavior and Development in Bacillus subtilis

2006 ◽  
Vol 188 (12) ◽  
pp. 4442-4452 ◽  
Author(s):  
Esteban Lombardía ◽  
Adrián J. Rovetto ◽  
Ana L. Arabolaza ◽  
Roberto R. Grau
Keyword(s):  
Bacillus Subtilis ◽  
Social Behavior ◽  
Quorum Sensing ◽  
Cell Communication ◽  
Model Organism ◽  
Signal Molecules ◽  
Light Production ◽  
The Social ◽  
Dependent Cell ◽  
Regulatory Feedback Loop

ABSTRACT Cell-to-cell communication in bacteria is mediated by quorum-sensing systems (QSS) that produce chemical signal molecules called autoinducers (AI). In particular, LuxS/AI-2-dependent QSS has been proposed to act as a universal lexicon that mediates intra- and interspecific bacterial behavior. Here we report that the model organism Bacillus subtilis operates a luxS-dependent QSS that regulates its morphogenesis and social behavior. We demonstrated that B. subtilis luxS is a growth-phase-regulated gene that produces active AI-2 able to mediate the interspecific activation of light production in Vibrio harveyi. We demonstrated that in B. subtilis, luxS expression was under the control of a novel AI-2-dependent negative regulatory feedback loop that indicated an important role for AI-2 as a signaling molecule. Even though luxS did not affect spore development, AI-2 production was negatively regulated by the master regulatory proteins of pluricellular behavior, SinR and Spo0A. Interestingly, wild B. subtilis cells, from the undomesticated and probiotic B. subtilis natto strain, required the LuxS-dependent QSS to form robust and differentiated biofilms and also to swarm on solid surfaces. Furthermore, LuxS activity was required for the formation of sophisticated aerial colonies that behaved as giant fruiting bodies where AI-2 production and spore morphogenesis were spatially regulated at different sites of the developing colony. We proposed that LuxS/AI-2 constitutes a novel form of quorum-sensing regulation where AI-2 behaves as a morphogen-like molecule that coordinates the social and pluricellular behavior of B. subtilis.

CellTalkDB: a manually curated database of ligand–receptor interactions in humans and mice

2020 ◽  
Author(s):  
Xin Shao ◽  
Jie Liao ◽  
Chengyu Li ◽  
Xiaoyan Lu ◽  
Junyun Cheng ◽  
...  
Keyword(s):  
Single Cell ◽  
Protein Interactions ◽  
Cell Communication ◽  
Systematic Investigation ◽  
Protein Protein Interactions ◽  
Biological Phenomena ◽  
Type Composition ◽  
Dependent Cell ◽  
Multicellular Organisms ◽  
Cell Cell

Abstract Cell–cell communications in multicellular organisms generally involve secreted ligand–receptor (LR) interactions, which is vital for various biological phenomena. Recent advancements in single-cell RNA sequencing (scRNA-seq) have effectively resolved cellular phenotypic heterogeneity and the cell-type composition of complex tissues, facilitating the systematic investigation of cell–cell communications at single-cell resolution. However, assessment of chemical-signal-dependent cell–cell communication through scRNA-seq relies heavily on prior knowledge of LR interaction pairs. We constructed CellTalkDB (http://tcm.zju.edu.cn/celltalkdb), a manually curated comprehensive database of LR interaction pairs in humans and mice comprising 3398 human LR pairs and 2033 mouse LR pairs, through text mining and manual verification of known protein–protein interactions using the STRING database, with literature-supported evidence for each pair. Compared with SingleCellSignalR, the largest LR-pair resource, CellTalkDB includes not only 2033 mouse LR pairs but also 377 additional human LR pairs. In conclusion, the data on human and mouse LR pairs contained in CellTalkDB could help to further the inference and understanding of the LR-interaction-based cell–cell communications, which might provide new insights into the mechanism underlying biological processes.

scholarly journals Phytocompound Mediated Blockage of Quorum Sensing Cascade in ESKAPE Pathogens

Antibiotics ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 61
Author(s):  
Sreejita Ghosh ◽  
Dibyajit Lahiri ◽  
Moupriya Nag ◽  
Ankita Dey ◽  
Soumya Pandit ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Regulation Of Gene Expression ◽  
Cell Communication ◽  
Natural Compounds ◽  
Bacterial Pathogenesis ◽  
Novel Drugs ◽  
Pharmacological Studies ◽  
Dependent Cell ◽  
Eskape Pathogens ◽  
New Strategies

Increased resistance of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp. (ESKAPE) pathogens against various drugs has enhanced the urge for the development of alternate therapeutics. Quorum sensing (QS) is a density dependent cell-to-cell communication mechanism responsible for controlling pathogenicity with the regulation of gene expression. Thus, QS is considered a potential target for the development of newer anti-biofilm agents that do not depend on the utilization of antibiotics. Compounds with anti-QS effects are known as QS inhibitors (QSIs), and they can inhibit the QS mechanism that forms the major form in the development of bacterial pathogenesis. A diverse array of natural compounds provides a plethora of anti-QS effects. Over recent years, these natural compounds have gained importance as new strategies for combating the ESKAPE pathogens and inhibiting the genes involved in QS. Different pharmacognostical and pharmacological studies have been carried out so far for identification of novel drugs or for the discovery of their unique structures that may help in developing more effective anti-biofilm therapies. The main objective of this review is to discuss the various natural compounds, so far identified and their employed mechanisms in hindering the genes responsible for QS leading to bacterial pathogenesis.

scholarly journals Patterned expression of Pannexin 1 channels in the adult cerebellar Purkinje cells

2018 ◽  
Author(s):  
Visou Ady ◽  
David Dubayle ◽  
Pascale Le Blanc ◽  
Valery Shestopalov ◽  
Claude Meunier ◽  
...  
Keyword(s):  
Cell Death ◽  
Purkinje Cells ◽  
Cell Communication ◽  
Cerebellar Nuclei ◽  
Modular Architecture ◽  
Pannexin 1 ◽  
Zebrin Ii ◽  
Dependent Cell ◽  
Cerebellar Purkinje Cells ◽  
Ensemble Activity

AbstractPannexin1 (PanX1) are recently discovered proteins that can form large pore channels at the cell surface. They have been implicated in ATP-dependent cell-to-cell communication and in several pathophysiological processes such as inflammation, cell death and epilepsy. Using immunohistochemistry in the adult mouse, we describe the presence of PanX1 in the deep cerebellar nuclei, in large cells of the granular layer, presumably Golgi interneurones, in some Bergmann glia radial processes as well as in the soma and dendrites of Purkinje cells. In the latter, PanX1, like many other proteins, distribute heterogeneously. Only Zebrin II-positive Purkinje cells express PanX1, in accordance with the so-called “zebra-striped” modular architecture of the cerebellum. This distribution in zebra-stripes suggest that PanX1 may contribute to the control of ensemble activity within cerebellar microdomains or to the response of Purkinje cell to excitotoxicity and cell-death messages.

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