Inferred slow inward current in snail neurones

Nature ◽  
1974 ◽  
Vol 250 (5467) ◽  
pp. 574-576 ◽  
Author(s):  
H. D. LUX ◽  
R. ECKERT
Keyword(s):  
Slow Inward Current ◽  
Inward Current ◽  
Snail Neurones

Role of cyclic AMP in a serotonin-evoked slow inward current in snail neurones

Nature ◽  
1981 ◽  
Vol 290 (5809) ◽  
pp. 783-785 ◽  
Author(s):  
Philippe Deterre ◽  
Danièle Paupardin-Tritsch ◽  
Joël Bockaert ◽  
Hersch M. Gerschenfeld
Keyword(s):  
Cyclic Amp ◽  
Slow Inward Current ◽  
Inward Current ◽  
Snail Neurones

Effects of ischemic conditions and reperfusion on depolarization-induced automaticity

1988 ◽  
Vol 255 (5) ◽  
pp. H992-H999 ◽  
Author(s):  
R. Mohabir ◽  
G. R. Ferrier
Keyword(s):  
Membrane Potential ◽  
Action Potential ◽  
Action Potentials ◽  
Cycle Length ◽  
Slow Inward Current ◽  
Potential Range ◽  
Ischemia And Reperfusion ◽  
Slow Response ◽  
Inward Current ◽  
High Membrane Potential

The inducibility of slow-response automaticity was assessed during ischemic conditions and reperfusion by application of extracellular current. Isolated canine Purkinje fibers were depolarized to membrane potentials less than -65 mV to elicit depolarization-induced automaticity (DIA). Ischemic conditions increased the cycle length of DIA and, in some tissues, prevented sustained DIA or completely abolished DIA. The magnitude of depolarization required to elicit DIA also increased. Inhibition of DIA occurred at a time when action potential plateaus were abbreviated. The effect of reperfusion on DIA was biphasic. Initial reappearance of DIA was followed by inhibition and reduction of the membrane potential range over which DIA could be elicited. Plateaus of action potentials initiated at high membrane potential were abbreviated at this time. DIA returned again as reperfusion effects dissipated. Phasic changes in the inducibility of DIA may represent changes in availability of the slow inward current and may regulate the timing and types of arrhythmic activity occurring with ischemia and reperfusion.

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