Intermolecular Relationship between Neutral-salt-soluble and Acid-soluble Collagen

Nature ◽  
1968 ◽  
Vol 217 (5124) ◽  
pp. 168-169 ◽  
Author(s):  
R. J. DAVIDSON ◽  
D. R. COOPER
Keyword(s):  
Neutral Salt ◽  
Soluble Collagen ◽  
Acid Soluble Collagen

scholarly journals The effect of ultraviolet irradiation on acid-soluble collagen

1967 ◽  
Vol 105 (3) ◽  
pp. 965-969 ◽  
Author(s):  
R. J. Davidson ◽  
D. R. Cooper
Keyword(s):  
Conformational Changes ◽  
Ultraviolet Irradiation ◽  
Irradiation Dose ◽  
Helical Structure ◽  
Neutral Salt ◽  
Soluble Collagen ◽  
Acid Soluble Collagen ◽  
Skin Collagen ◽  
Principal Effect ◽  
Chain Lengths

1. A study has been made of the effect of ultraviolet irradiation on the conformational changes taking place in cooled solutions of thermally denatured acid-soluble calf-skin collagen. 2. The increase in negative rotation and viscosity at 15° for irradiated and thermally denatured collagen solutions becomes less as the irradiation dose is increased. 3. The principal effect of ultraviolet irradiation is the fission of the primary collagen chains, eventually yielding chain lengths incapable of stabilizing a helical structure. 4. The effects of ultraviolet irradiation on acid-soluble collagen may be closely correlated with similar effects on neutral salt-soluble collagen.

scholarly journals The effect of ultraviolet irradiation on soluble collagen

1965 ◽  
Vol 97 (1) ◽  
pp. 139-147 ◽  
Author(s):  
DR Cooper ◽  
RJ Davidson
Keyword(s):  
Ultraviolet Irradiation ◽  
Optical Rotation ◽  
Gel Filtration ◽  
Collagen Molecule ◽  
Neutral Salt ◽  
Soluble Collagen ◽  
Acid Soluble Collagen ◽  
Skin Collagen ◽  
Kinetics Of ◽  
Calf Skin

1. The effect of ultraviolet irradiation on acid-soluble and neutral-salt-soluble calf-skin collagen was studied by chromatography, gel filtration, amino acid analysis and sedimentation of the sub-units, and the reaction kinetics of degradation were obtained from viscosity and optical rotation measurements. 2. It was demonstrated that, whereas the structure of neutral-salt-soluble calf-skin collagen may be represented by the formula (alpha(1))(2)alpha(2), the acid-soluble extract has the formula alpha(1).(alpha(2))(2). The acid-soluble collagen is also unusual in containing a large amount of a component that could be beta(22). 3. Ultraviolet irradiation causes the progressive degradation of the collagen molecule into smaller molecular fragments that subsequently lose their helical nature. The rate constants show that the denaturation of soluble collagens by ultraviolet irradiation is much slower, under the conditions used, than denaturation by heat or enzymes.

scholarly journals The effect of γ-irradiation on soluble collagen

1968 ◽  
Vol 107 (1) ◽  
pp. 29-34 ◽  
Author(s):  
R. J. Davidson ◽  
D. R. Cooper
Keyword(s):  
Conformational Changes ◽  
Irradiation Dose ◽  
Neutral Salt ◽  
Native Structure ◽  
Γ Irradiation ◽  
Peptide Bonds ◽  
Soluble Collagen ◽  
Acid Soluble Collagen ◽  
Principal Effect ◽  
Initial Effect

1. A study was made of the effect of γ-irradiation on the sub-unit composition, as well as the conformational changes taking place in cooled solutions of thermally denatured neutral-salt-soluble and acid-soluble collagen. 2. The increase in negative rotation and viscosity at 15° for irradiated and thermally denatured collagen solutions becomes less as the irradiation dose is increased. 3. The initial effect of γ-irradiation is the depolymerization of the dimers found in both neutral-salt-soluble and acid-soluble collagen. 4. The principal effect of γ-irradiation up to 10 Mrads is the fission of peptide bonds, yielding crystalline irradiation-resistant portions of the molecule incapable of associating to the native structure. 5. The effects of γ-irradiation on both neutral-salt-soluble and acid-soluble collagen are very similar and bear a close resemblance to the effects induced by ultraviolet irradiation.

scholarly journals Some properties of neutral-salt-soluble collagen. 1

1960 ◽  
Vol 76 (3) ◽  
pp. 452-463 ◽  
Author(s):  
J. H. Fessler
Keyword(s):  
Neutral Salt ◽  
Soluble Collagen

scholarly journals The Characterization of Acid Soluble Collagen from Sheep Tail Tendon

2021 ◽  
Author(s):  
Budjav Jadamba ◽  
Enerelt Urnukhsaikhan ◽  
Anujin Gantulga ◽  
Sugar Lkhagvachuluun ◽  
Enkhsaikhan Lkhagvasuren ◽  
...  
Keyword(s):  
Soluble Collagen ◽  
Acid Soluble Collagen ◽  
Tail Tendon
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