Antibody Response of Thymectomized Rats after Local Irradiation of the Spleen

Nature ◽  
1967 ◽  
Vol 215 (5103) ◽  
pp. 868-869 ◽  
Author(s):  
V. S. ŠLJIVIĆ ◽  
MILICA Ž. PETROVIĆ
Keyword(s):  
Antibody Response ◽  
Local Irradiation ◽  
Irradiation Of The Spleen

scholarly journals Bone Marrow Changes in Patients with Chronic Leukemia Treated by Splenic X-irradiation

Blood ◽  
1953 ◽  
Vol 8 (8) ◽  
pp. 687-692 ◽  
Author(s):  
F. W. GUNZ
Keyword(s):  
Bone Marrow ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Myeloid Cells ◽  
X Rays ◽  
Local Irradiation ◽  
X Irradiation ◽  
Immature Myeloid Cells ◽  
Irradiation Of The Spleen ◽  
Therapeutic Doses

Abstract 1. Following therapeutic x-irradiation of the spleen in patients suffering from chronic myeloid leukemia alterations in the composition of the bone marrow have been noted in a high proportion of cases. These consisted of a decrease in the number of immature myeloid cells or an increase in that of the immature erythroid cells or both. 2. Eighty minutes after local irradiation of the leukemic spleen with therapeutic doses of x-rays there was found a diminution in the number of mitoses among myeloid cells in the bone marrow.

Zostavax Elicits Antibody Response in Younger Group

2007 ◽  
Vol 37 (11) ◽  
pp. 24
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Antibody Response

Radioimmunotherapy of Xenografts of Human Pancreatic Carcinomas - Intravenous and Intratumoral Application of 131l-Labelled Monoclonal Antibodies

1986 ◽  
Vol 25 (06) ◽  
pp. 235-238 ◽  
Author(s):  
S. Lander ◽  
M. Bahlo ◽  
R. Montz ◽  
R. Klapdor
Keyword(s):  
Irradiation Dose ◽  
Tumor Regression ◽  
Whole Body ◽  
Inhibit Tumor Growth ◽  
Local Irradiation ◽  
Clinical Value ◽  
Direct Radiation ◽  
Intravenous Injections ◽  
Induce Tumor Regression ◽  
High Doses

The effects of radioimmunotherapy were tested in xenografts of 2 different human pancreatic carcinomas comparing the intravenous and intratumoral application. On principle, intravenous injections of high doses of 131l-anti- Ca 19-9 or -BW 494/32 may inhibit tumor growth. In view of the low direct radiation dose (360-2100 rad), however, other factors than direct toxic effects have to be discussed, e. g. systemic effects due to the high whole-body irradiation. Intratumoral application, however, may induce tumor regression or growth inhibition due to the high local irradiation dose. Consequently, this treatment modality might be of clinical value at least in some patients.

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