Effects of Synthetic Angiotensin on Plasma Free Fatty Acid and Blood Glucose-levels

Nature ◽  
1966 ◽  
Vol 209 (5026) ◽  
pp. 922-923 ◽  
Author(s):  
J. NAKANO ◽  
T. KUSAKARI
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid ◽  
Glucose Levels ◽  
Blood Glucose Levels

Effect of glucagon on thermogenesis in the pigeon.

1977 ◽  
Vol 232 (5) ◽  
pp. E451
Author(s):  
E Hohtola ◽  
R Hissa ◽  
S Saarela
Keyword(s):  
Oxygen Consumption ◽  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid ◽  
Energy Reserves ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Plasma Ffa ◽  
Adrenergic Blocking

The effects of glucagon injection on temperature regulation and some metabolic parameters were studied in the pigeon. Glucagon (100 microng/kg) always inhibited shivering and caused a fall in the oxygen consumption and body temperature of the unanesthetized pigeon at + 6 degrees C. At + 34 degrees C, the same dose of glucagon had no effect on these parameters. At 22 degrees C, glucagon produced an elevation in plasma free fatty acid (FFA) and blood glucose levels. The rise in FFA at 22 degrees C coincided with the suppression of shivering at 6 degrees C. The glucagon-mediated rise in plasma FFA, but not glucose level, was potentiated by cold ambient temperature. Adrenergic blocking agents given prior to glucagon did not abolish its effects. Phentolamine even prolonged the absence and accelerated the suppression of shivering. A dissociation in the mechanisms by which catecholamines and glucagon suppress shivering is suggested. Although mobilizing energy reserves, glucagon does not seem to be calorigenic in the pigeon at this dose. The interpretation of the changes in plasma FFA levels is discussed in relation to fuel consumption during shivering.

HYPOGLYCEMIA AND HYPERINSULINEMIA ASSOCIATED WITH ERYTHROBLASTOSIS FETALIS

PEDIATRICS ◽  
1969 ◽  
Vol 43 (2) ◽  
pp. 217-225
Author(s):  
Kari O. Raivio ◽  
Kalle Österlund
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Binding Capacity ◽  
Plasma Free Fatty Acid ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Plasma Insulin Levels ◽  
Low Glucose ◽  
Bilirubin Binding

In a survey of blood glucose levels in 232 erythroblastotic infants during the first 3 days of life, 12 cases of significant hypoglycemia were revealed. Most of these had a severe primary disease; the incidence of hypoglycemia was 17.8% in patients with cord hemoglobin concentrations below 10 gm per 100 ml and 1.9% in those with higher cord hemoglobin levels. The low glucose values were usually observed during the first day of life and were unassociated with recognizable symptoms. Plasma insulin levels, determined in 39 cases before age 24 hours and prior to treatment, were shown to be negatively correlated with the cord hemoglobin concentrations. Hyperinsulinemia, directly correlated with the severity of the erythroblastosis, is postulated to be the cause of the low blood glucose levels. As another consequence of the hyperinsulinemia, a depression of the plasma free fatty acid concentrations was documented. The mechanism of the hyperinsulinemia, the therapeutic and prognostic implications of the hypoglycemia, as well as the effect of the depression of free fatty acid levels on the bilirubin-binding capacity of serum are briefly discussed.

Reduced running endurance in gluconeogenesis-inhibited rats

1986 ◽  
Vol 251 (1) ◽  
pp. R137-R142 ◽  
Author(s):  
H. B. John-Alder ◽  
R. M. McAllister ◽  
R. L. Terjung
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Plasma Free Fatty Acid ◽  
Hepatic Glycogen ◽  
Endurance Time ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lactate Levels ◽  
Blood Lactate Levels

The functional significance of gluconeogenesis in prolonging endurance during submaximal activity was assessed in untrained and endurance-trained rats. Gluconeogenesis was inhibited at the phosphoenolpyruvate carboxykinase reaction by 3-mercaptopicolinic acid (3-MPA). Endurance was significantly reduced by 3-MPA in untrained (-32%; P less than 0.005) and in trained rats (-26%; P less than 0.001). Metabolic correlates of fatigue were examined in trained rats. At exhaustion, 3-MPA-treated rats had only 3% of resting hepatic glycogen, 46% of resting white quadriceps glycogen, and 37% of resting blood glucose. All of these substrates were at higher levels in sham-injected controls after the same duration of running (130 min). Glycogen levels in red quadriceps, blood lactate levels, and blood glycerol levels were not different between groups. Plasma free fatty acid levels were elevated to the same extent in both groups after 90 min of activity, remained high at 130 min in controls, but had returned to resting levels in the severely hypoglycemic 3-MPA-treated rats at exhaustion. The results indicate that gluconeogenesis is important for maintaining blood glucose levels and for prolonging endurance time during submaximal activity.

Free fatty acid receptor 1 agonist, MR1704, lowers blood glucose levels in rats unresponsive to the sulfonylurea, glibenclamide

2017 ◽  
Vol 79 (1) ◽  
pp. 16-21
Author(s):  
Naoto Tsuda ◽  
Atsuko Kawaji ◽  
Mitsuhiro Takagi ◽  
Chika Higashi ◽  
Masaki Nakamura ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Acid Receptor ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Free Fatty Acid Receptor ◽  
Fatty Acid Receptor

Effects of Carbohydrate and Chromium Ingestion during Intermittent High-Intensity Exercise to Fatigue

2000 ◽  
Vol 10 (4) ◽  
pp. 476-485 ◽  
Author(s):  
J. Mark Davis ◽  
Ralph S. Welsh ◽  
Nathan A. Alderson
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Fatigue Test ◽  
Exercise Capacity ◽  
High Intensity ◽  
Plasma Free Fatty Acid ◽  
Chromium Picolinate ◽  
Double Blind ◽  
Physically Active

Purpose:This study was designed to test the hypothesis that addition of chromium (Cr) to a carbohydrate-electrolyte drink would enhance the reported benefits of carbohydrate on exercise capacity during intermittent high-intensity shuttle running.Methods:Eight physically active men performed 3 exercise trials while ingesting 6% carbohydrate-electrolyte (CHO), CHO plus chromium picolinate (400 μg) (CHO + Cr+3). or placebo (P) using a double-blind, counterbalanced design. Each trial consisted of 5 × 15 min bouts of shuttle running (walk, sprint, and run at 95 and 55% of estimated V̇O2max, separated by 3-min rest). This was followed by a fatigue test (running alternating 20-m lengths at 55 and 95% of estimated V̇O2, until fatigue).Results:During the standardized shuttle running, blood glucose was higher with both CHO and CHO + Cr+3 than P. Plasma free fatty acid was higher in P than both CHO and CHO + Cr+3 at 75 min of exercise and at fatigue. In the fatigue test, subjects ran longer with both CHO and CHO + Cr+3 than P.Conclusions:The data confirm an ergogenic benefit of ingesting CHO during exercise designed to imitate sports like basketball, soccer, and hockey, but do not support the hypothesis that the addition of Cr would enhance this effect.

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