Urinary Excretion of Acetylsalicylic Acid in Man

Nature ◽  
1966 ◽  
Vol 209 (5023) ◽  
pp. 620-621 ◽  
Author(s):  
A. J. CUMMINGS ◽  
M. L. KING
Keyword(s):  
Urinary Excretion ◽  
Acetylsalicylic Acid

The Effect of Acetylsalicylic Acid, Caffeine, and Codeine on the Excretion of Phenacetin Metabolites

1972 ◽  
Vol 50 (8) ◽  
pp. 809-816 ◽  
Author(s):  
M. Henry Gault ◽  
Nasrollah T. Shahidi ◽  
Alec Gabe
Keyword(s):  
Renal Failure ◽  
Urinary Excretion ◽  
Creatinine Clearance ◽  
Acetylsalicylic Acid ◽  
Total N ◽  
Drug Ingestion

The urinary excretion of total N-acetyl-p-aminophenol and conjugates (NAPA) and total 2-hydroxyphenetidin and conjugates (2-OHP) was studied after ingestion of 2 g phenacetin alone and also in combination with acetylsalicylic acid, caffeine, and codeine (APC and C). NAPA excretion was measured in 17 patients; seven had taken the combination analgesic preparation in large amounts for 5 or more years and 11 had values for creatinine clearance of < 50 ml/min. NAPA excretion was measured for 96 h after drug ingestion and 2-OHP for at least 24 h in 15 patients of the same group. Excretion of total NAPA and 2-OHP was significantly reduced when phenacetin was ingested as APC and C compared with excretion when phenacetin was given alone. In the presence of renal failure NAPA excretion was merely delayed, whereas 2-OHP excretion was reduced or absent.

Diflunisal, a New-Acting Analgesic and Prostaglandin Inhibitor: Effect of Concomitant Acetylsalicylic Acid Therapy on Ototoxicity and on Disposition of Both Drugs

1979 ◽  
Vol 7 (1) ◽  
pp. 61-68 ◽  
Author(s):  
P Schulz ◽  
C V Perrier ◽  
F Ferber-Perret ◽  
W J A VandenHeuvel ◽  
S L Steelman
Keyword(s):  
Single Dose ◽  
Urinary Excretion ◽  
Acetylsalicylic Acid ◽  
Blood Levels ◽  
Concomitant Therapy ◽  
Significant Drop ◽  
Acid Therapy ◽  
Prostaglandin Inhibitor ◽  
Clinically Significant ◽  
Higher Doses

Intermittent and concomitant acetylsalicylic acid (ASA) therapy was superimposed onto a 21-day regimen with diflunisal 250 mg b.i.d. Low doses of ASA (600 mg single dose or 300 mg q.i.d.) did not influence significantly diflunisal blood levels whereas a 600 mg q.i.d. dosing caused a small significant drop, especially at trough level. This drop is not expected to be clinically significant. No ototoxicity could be demonstrated with any treatment of diflunisal though four of fourteen subjects reported mild tinnitus during concomitant therapy at the higher doses of ASA. Diflunisal at 375 mg b.i.d. failed to alter the metabolism of a single dose of labelled ASA (600 mg) as judged by plasma levels, urinary excretion and plasma binding. Daily urinary excretion of prostaglandins E1 and E2 major metabolite was decreased by about 70% by diflunisal.

ACETYLSALICYLIC ACID AND URINARY EXCRETION OF ADRENOCORTICAL STEROIDS

The Lancet ◽  
1951 ◽  
Vol 257 (6658) ◽  
pp. 771-773 ◽  
Author(s):  
H. Van Cauwenberge ◽  
C. Heusghem
Keyword(s):  
Urinary Excretion ◽  
Acetylsalicylic Acid

Urinary Excretion of Acetylsalicylic Acid in Female Volunteers

2003 ◽  
Vol 6 (17) ◽  
pp. 1490-1493
Author(s):  
Kouser Fatima ◽  
Haq Nawaz Bhatti . ◽  
Bushra Majeed .
Keyword(s):  
Urinary Excretion ◽  
Acetylsalicylic Acid

Urinary Excretion of Acetylsalicylic Acid in Healthy Male Volunteers

2003 ◽  
Vol 6 (16) ◽  
pp. 1413-1415
Author(s):  
Bazghah Sadaf Siddiqui ◽  
Haq Nawaz Bhatti . ◽  
Ambreen Ijaz . ◽  
Saba Rasheed . ◽  
Bushra Saleem .
Keyword(s):  
Urinary Excretion ◽  
Acetylsalicylic Acid ◽  
Healthy Male ◽  
Healthy Male Volunteers ◽  
Male Volunteers

Effect of Aspirin on Urinary Excretion of 6-Ketoprostaglandin F1α

1983 ◽  
Vol 64 (4) ◽  
pp. 395-398 ◽  
Author(s):  
P. B. B. Jones ◽  
R. G. G. Russell
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Acetylsalicylic Acid ◽  
Vascular Tissue ◽  
Excretion Rate ◽  
Human Subjects ◽  
Normal Human ◽  
High Doses ◽  
Prostacyclin Production

1. We studied the effect of oral administration of acetylsalicylic acid (1200 mg/day for 3 days) on the urinary excretion of 6-ketoprostaglandin F1α in normal human subjects as an index of prostacyclin production in vivo. 2. The concentrations and excretion rate in urine fell to 45% of pretreatment levels in 3 days, but returned to pretreatment values after 7 days. 3. These results suggest that production of prostacyclin in vivo is only partially inhibited by high doses of aspirin and that there are sites of production of prostacyclin which are protected from inhibition by aspirin and which contribute to urinary 6-ketoprostaglandin F1α. The measurement of 6-ketoprostaglandin F1α in urine may therefore be of only limited value as an index of the metabolism of vascular tissue in vivo.

Increased urinary excretion of the histamine metabolite Nι-methylhistamine during acetylsalicylic acid provocation in chronic urticaria patients

1990 ◽  
Vol 30 (1-2) ◽  
pp. 254-257 ◽  
Author(s):  
E. Oosting ◽  
S. H. Kardaun ◽  
H. M. G. Doeglas ◽  
P. Los ◽  
J. G. R. Monchy
Keyword(s):  
Urinary Excretion ◽  
Acetylsalicylic Acid ◽  
Chronic Urticaria ◽  
Histamine Metabolite
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