Citrate as an Intermediary in the Inhibition of Phosphofructokinase in Rat Heart Muscle by Fatty Acids, Ketone Bodies, Pyruvate, Diabetes and Starvation

P. B. GARLAND; P. J. RANDLE; E. A. NEWSHOLME

doi:10.1038/200169a0

Citrate as an Intermediary in the Inhibition of Phosphofructokinase in Rat Heart Muscle by Fatty Acids, Ketone Bodies, Pyruvate, Diabetes and Starvation

Nature ◽

10.1038/200169a0 ◽

1963 ◽

Vol 200 (4902) ◽

pp. 169-170 ◽

Cited By ~ 282

Author(s):

P. B. GARLAND ◽

P. J. RANDLE ◽

E. A. NEWSHOLME

Keyword(s):

Fatty Acids ◽

Heart Muscle ◽

Rat Heart ◽

Ketone Bodies

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Interconversion of pyruvate dehydrogenase in rat heart muscle upon perfusion with fatty acids or ketone bodies

FEBS Letters ◽

10.1016/0014-5793(71)80641-5 ◽

1971 ◽

Vol 15 (4) ◽

pp. 295-298 ◽

Cited By ~ 80

Author(s):

O. Wieland ◽

H.v. Funcke ◽

G. Löffler

Keyword(s):

Fatty Acids ◽

Pyruvate Dehydrogenase ◽

Heart Muscle ◽

Rat Heart ◽

Ketone Bodies

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Regulation of glucose uptake by muscle. 7. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, on the concentrations of hexose phosphates, nucleotides and inorganic phosphate in perfused rat heart

Biochemical Journal ◽

10.1042/bj0930641 ◽

1964 ◽

Vol 93 (3) ◽

pp. 641-651 ◽

Cited By ~ 126

Author(s):

EA Newsholme ◽

PJ Randle

Keyword(s):

Fatty Acids ◽

Glucose Uptake ◽

Rat Heart ◽

Inorganic Phosphate ◽

Alloxan Diabetes ◽

Ketone Bodies ◽

Perfused Rat Heart ◽

Hexose Phosphates

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Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation, on pyruvate metabolism and on lactate-pyruvate and l-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscles

Biochemical Journal ◽

10.1042/bj0930665 ◽

1964 ◽

Vol 93 (3) ◽

pp. 665-678 ◽

Cited By ~ 150

Author(s):

PB Garland ◽

EA Newsholme ◽

PJ Randle

Keyword(s):

Fatty Acids ◽

Glucose Uptake ◽

Rat Heart ◽

Alloxan Diabetes ◽

Ketone Bodies ◽

Phosphate Concentration ◽

Dihydroxyacetone Phosphate ◽

Rat Diaphragm ◽

Pyruvate Metabolism ◽

Concentration Ratios

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Regulation of glucose uptake by muscles. 10. Effects of alloxan-diabetes, starvation, hypophysectomy and adrenalectomy, and of fatty acids, ketone bodies and pyruvate, on the glycerol output and concentrations of free fatty acids, long-chain fatty acyl-coenzyme A, glycerol phosphate and citrate-cycle intermediates in rat heart and diaphragm muscles

Biochemical Journal ◽

10.1042/bj0930678 ◽

1964 ◽

Vol 93 (3) ◽

pp. 678-687 ◽

Cited By ~ 182

Author(s):

PB Garland ◽

PJ Randle

Keyword(s):

Fatty Acids ◽

Free Fatty Acids ◽

Rat Heart ◽

Alloxan Diabetes ◽

Ketone Bodies ◽

Fatty Acyl ◽

Glycerol Phosphate ◽

Citrate Cycle ◽

Acyl Coenzyme A ◽

Long Chain

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DEPRESSION OF CONTRACTILITY IN RAT HEART MUSCLE BY FREE FATTY ACIDS DURING HYPOXIA

The Lancet ◽

10.1016/s0140-6736(69)92277-6 ◽

1969 ◽

Vol 294 (7625) ◽

pp. 825-826 ◽

Cited By ~ 6

Author(s):

A.H Henderson ◽

A.S Most ◽

E.H Sonnenblick

Keyword(s):

Fatty Acids ◽

Free Fatty Acids ◽

Heart Muscle ◽

Rat Heart

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Inhibition of pyruvate kinase by free fatty acids in rat heart muscle

Biochimica et Biophysica Acta (BBA) - Enzymology ◽

10.1016/0005-2744(69)90169-7 ◽

1969 ◽

Vol 171 (2) ◽

pp. 355-357 ◽

Cited By ~ 18

Author(s):

Etsuro Tsutsumi ◽

Fumio Takenaka

Keyword(s):

Fatty Acids ◽

Free Fatty Acids ◽

Pyruvate Kinase ◽

Heart Muscle ◽

Rat Heart

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Inhibition of the Phosphofructokinase Reaction in Perfused Rat Heart by Respiration of Ketone Bodies, Fatty Acids and Pyruvate

Nature ◽

10.1038/193270a0 ◽

1962 ◽

Vol 193 (4812) ◽

pp. 270-271 ◽

Cited By ~ 212

Author(s):

E. A. NEWSHOLME ◽

P. J. RANDLE ◽

K. L. MANCHESTER

Keyword(s):

Fatty Acids ◽

Rat Heart ◽

Ketone Bodies ◽

Perfused Rat Heart

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Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles

Biochemical Journal ◽

10.1042/bj0930652 ◽

1964 ◽

Vol 93 (3) ◽

pp. 652-665 ◽

Cited By ~ 429

Author(s):

PJ Randle ◽

EA Newsholme ◽

PB Garland

Keyword(s):

Fatty Acids ◽

Glucose Uptake ◽

Rat Heart ◽

Alloxan Diabetes ◽

Ketone Bodies ◽

Metabolic Fate

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Toxicity of free fatty acids for cultured rat heart muscle and endothelioid cells. II. Unsaturated long-chain fatty acids

Toxicology ◽

10.1016/s0300-483x(78)90839-9 ◽

1978 ◽

Vol 11 ◽

pp. 119-125 ◽

Cited By ~ 20

Author(s):

D.G. Wenzel ◽

T.W. Hale

Keyword(s):

Fatty Acids ◽

Free Fatty Acids ◽

Heart Muscle ◽

Rat Heart ◽

Long Chain Fatty Acids ◽

Long Chain ◽

Chain Fatty Acids

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Effect of Fatty Acids, Ketone Bodies, Diabetes and Starvation on Pyruvate Metabolism in Rat Heart and Diaphragm Muscle

Nature ◽

10.1038/195381a0 ◽

1962 ◽

Vol 195 (4839) ◽

pp. 381-383 ◽

Cited By ~ 152

Author(s):

P. B. GARLAND ◽

E. A. NEWSHOLME ◽

P. J. RANDLE

Keyword(s):

Fatty Acids ◽

Rat Heart ◽

Ketone Bodies ◽

Diaphragm Muscle ◽

Pyruvate Metabolism

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