Formation of 2,3-Dihydroxybenzoic Acid in Fermentation Liquors during the Submerged Culture Production of Lysergic Acid α-Hydroxyethylamide by Claviceps paspali Stevens and Hall

Nature ◽  
1961 ◽  
Vol 192 (4802) ◽  
pp. 552-553 ◽  
Author(s):  
F. ARCAMONE ◽  
E. B. CHAIN ◽  
A. FERRETTI ◽  
P. PENNELLA
Keyword(s):  
Submerged Culture ◽  
Lysergic Acid ◽  
Dihydroxybenzoic Acid ◽  
Culture Production ◽  
Claviceps Paspali

Production of Lysergic Acid Derivatives by a Strain of Claviceps paspali Stevens and Hall in Submerged Culture

Nature ◽  
1960 ◽  
Vol 187 (4733) ◽  
pp. 238-239 ◽  
Author(s):  
F. ARCAMONE ◽  
C. BONINO ◽  
E. B. CHAIN ◽  
A. FERRETTI ◽  
P. PENNELLA ◽  
...  
Keyword(s):  
Submerged Culture ◽  
Lysergic Acid ◽  
Claviceps Paspali

Production of a new lysergic acid derivative in submerged culture by a strain of Claviceps paspali Stevens & Hall

1961 ◽  
Vol 155 (958) ◽  
pp. 26-54 ◽  
Keyword(s):  
Acid Derivative ◽  
Submerged Culture ◽  
Acid Amide ◽  
Transformation Products ◽  
Culture Conditions ◽  
Lysergic Acid ◽  
Morphological Properties ◽  
Isolation And Purification ◽  
High Yields ◽  
Claviceps Paspali

1. The production of a new lysergic acid derivative, identified as D-lysergic acid α -hydroxyethylamide, in submerged culture and in yields up to 1 mg/ml. and above, by a strain of Claviceps paspali Stevens & Hall is reported; this substance can be converted in high yields into D-lysergic acid amide. 2. The morphological properties of this strain under different culture conditions are examined and it is shown that it grows in a form resembling natural sclerotia. 3. The biochemical culture conditions for the production of the new lysergic acid derivative in shake flasks and in stirred fermenters, the course of the fermentation, the methods for the isolation and purification of the substance and its transformation products and some of its chemical and physical properties are described.

Production of lysergic acid derivatives with immobilized Claviceps paspali mycelium

1989 ◽  
Vol 32 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Damjana Rozman ◽  
Elizabeta Pertot ◽  
Radovan Komel ◽  
Miro Prošek
Keyword(s):  
Lysergic Acid ◽  
Claviceps Paspali

Radioimmunoassay of Lysergic Acid Derivatives from Claviceps paspali Fermentation Cultures

Planta Medica ◽  
1982 ◽  
Vol 45 (07) ◽  
pp. 161-161
Author(s):  
T. Lehtola ◽  
A. Huhtikangas ◽  
J. Lundell ◽  
T. Vallanen
Keyword(s):  
Lysergic Acid ◽  
Claviceps Paspali

Preparation and properties of diphtheria toxoids in submerged culture. III. Development of a new semisynthetic medium

1968 ◽  
Vol 14 (10) ◽  
pp. 1155-1160 ◽  
Author(s):  
D. W. Stainer ◽  
J. M. C. Corkill ◽  
M. J. Scholte
Keyword(s):  
Submerged Culture ◽  
Inorganic Phosphate ◽  
Ferrous Sulphate ◽  
Growth Period ◽  
Main Ingredient ◽  
High Potency ◽  
Tryptic Digest ◽  
Deep Culture ◽  
Culture Production ◽  
Phosphate Solutions

A new medium has been developed which does not contain any meat digest products and is suitable for the deep-culture production of high-potency diphtheria toxins. The main ingredient is a commercially available, tryptic digest of casein known as N.Z. Amine type A. It has been found that when the iron, calcium, and phosphate levels in the medium are carefully controlled by suitable additions of ferrous sulphate, calcium chloride, and inorganic phosphate solutions, high levels of diphtheria toxin are regularly produced (200 Lf/ml in a 48-hour growth period).

scholarly journals Production of Lysergic Acid Derivatives in Submerged Culture

1967 ◽  
Vol 15 (6) ◽  
pp. 1270-1283
Author(s):  
John P. Rosazza ◽  
William J. Kelleher ◽  
Arthur E. Schwarting
Keyword(s):  
Submerged Culture ◽  
Lysergic Acid

scholarly journals Production of Lysergic Acid Derivatives in Submerged Culture

1967 ◽  
Vol 15 (6) ◽  
pp. 1270-1283 ◽  
Author(s):  
John P. Rosazza ◽  
William J. Kelleher ◽  
Arthur E. Schwarting
Keyword(s):  
Submerged Culture ◽  
Lysergic Acid
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