Multi-stranded Deoxyribonucleic Acid as determined by X-Irradiation

Nature ◽  
1961 ◽  
Vol 189 (4767) ◽  
pp. 833-834 ◽  
Author(s):  
LIEBE F. CAVALIERI ◽  
ROLAND FINSTON ◽  
BARBARA HATCH ROSENBERG
Keyword(s):  
Deoxyribonucleic Acid ◽  
X Irradiation

Effect of Repeated X-irradiation on the Process of Degradation of Deoxyribonucleic Acid

Nature ◽  
1964 ◽  
Vol 202 (4927) ◽  
pp. 106-107 ◽  
Author(s):  
B. MILETIĆ ◽  
Ž. KUĆAN ◽  
DJ. NOVAK
Keyword(s):  
Deoxyribonucleic Acid ◽  
X Irradiation

The influence of radiomimetic substances on deoxyribonucleic acid synthesis and function studied in Escherichia coli phage systems - II. Properties of coliphage T 2 treated with di(2-chloroethyl)methylamine

1959 ◽  
Vol 150 (941) ◽  
pp. 486-496 ◽  
Keyword(s):  
Deoxyribonucleic Acid ◽  
Acid Synthesis ◽  
Small Degree ◽  
Host Cells ◽  
Acid Moiety ◽  
Deoxyribonucleic Acid Synthesis ◽  
Protein Membrane ◽  
X Irradiation ◽  
And Function ◽  
Escherichia Coli Phage

An examination of the properties of T 2 coliphage, after treatment with the nitrogen mustard di(2-chloroethyl)methylamine, revealed a remarkable similarity to those of T 2 after X-irradiation. In particular, the phage remained capable of adsorption to the host cells and of combining with specific antibody, whilst showing a progressive loss of ability to kill the host cells with increasing dose. Further, a small degree of multiplicity and cross-reactivation was manifested, commensurate with that shown by phage X-irradiated in vitro . It is considered that these facts are consistent with the view that loss of plaque-forming ability is largely due to a failure of injection of the deoxyribonucleic acid moiety of the virus into the host cells following adsorption, an explanation already put forward by other workers in respect of X-rayed phage. This failure could arise by internal cross-linking of the DNA by the chloroethylamine, or of the DNA with the protein membrane. The experimental evidence supports the former proposal. The term 'radiomimetic' used in respect of di(2-chloroethyl)methylamine in the general title of this series is thus justifiable so far as phage inactivation is concerned.

X-Irradiation of Deoxyribonucleic Acid

Nature ◽  
1963 ◽  
Vol 200 (4908) ◽  
pp. 781-782 ◽  
Author(s):  
SHAN-CHING SUNG ◽  
J. H. QUASTEL
Keyword(s):  
Deoxyribonucleic Acid ◽  
X Irradiation

scholarly journals Pituitary Effect on Synthesis of Deoxyribonucleic Acid in Regenerating Rat Liver following Whole-body X-irradiation

Nature ◽  
1961 ◽  
Vol 192 (4809) ◽  
pp. 1309-1309 ◽  
Author(s):  
D. M. GOULD ◽  
K. W. FLOYD ◽  
R. W. WHITEHEAD ◽  
J. L. SANDERS
Keyword(s):  
Rat Liver ◽  
Deoxyribonucleic Acid ◽  
Whole Body ◽  
Regenerating Rat Liver ◽  
X Irradiation
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