Inhibitory Effect of Malonate on the Respiration of Brain Tissue, with Special Reference to the Potassium Effect

Nature ◽  
1953 ◽  
Vol 171 (4359) ◽  
pp. 881-882 ◽  
Author(s):  
Y. KIMURA ◽  
T. NIWA
Keyword(s):  
Special Reference ◽  
Brain Tissue ◽  
Inhibitory Effect ◽  
Potassium Effect

Alteration of the development of mammary hyperplastic alveolar nodules and uterine adenomyosis in SHN mice by different schedules of treatment with CB-154

1984 ◽  
Vol 107 (2) ◽  
pp. 245-249 ◽  
Author(s):  
T. Mori ◽  
H. Nagasawa
Keyword(s):  
Cell Proliferation ◽  
Mammary Gland ◽  
Special Reference ◽  
Day Treatment ◽  
Inhibitory Effect ◽  
Gland Cells ◽  
Age Dependent ◽  
Uterine Adenomyosis ◽  
Different Response ◽  
Mammary Gland Cells

Abstract. The effect of different schedules of bromocriptine-mesilate (CB-154; 0.2 mg/day) treatment on the development of precancerous mammary hyperplastic alveolar nodules (HAN) and uterine adenomyosis was investigated in a virgin SHN strain of mice. CB-154 treatment for 7 weeks beginning at 4 weeks of age enhanced the development of HAN at an advanced age, the shorter period of treatment having no effect. In contrast, spontaneous development of adenomyosis was markedly inhibited in mice treated with CB-154 for more than 4 weeks begining at 4 weeks of age, but not for less than 3 weeks of the treatment. The inhibitory effect of CB-154 was not counteracted by pituitary grafting. Furthermore, CB-154 treatment between 11 and 18 weeks of age also accelerated HAN formation, but had no effect on the development of adenomyosis. These results indicate that in mice a certain period of CB-154 treatment is necessary to produce changes in the development of HAN and adenomyosis, and that the inhibitory effect of CB-154 on the development of adenomyosis is age-dependent. The different response between mammary gland cells and uterine cells to CB-154 exposure is discussed with special reference to cell proliferation.

scholarly journals In vitro Inhibitory Effects of Cyperus esculentus L. (Tiger Nut) Tubers on some Enzymes Associated with Neurodegeneration and Iron- Induced Lipid Peroxidation in Rats’ Brain Tissue Homogenate

2020 ◽  
Vol 11 (2) ◽  
pp. 81-87
Author(s):  
Ayodeji Olabiyi ◽  
Keyword(s):  
Lipid Peroxidation ◽  
Brain Tissue ◽  
Radical Scavenging ◽  
Inhibitory Effect ◽  
Tissue Homogenate ◽  
Cyperus Esculentus ◽  
Butyryl Cholinesterase ◽  
Radical Scavenging Ability ◽  
Brain Tissue Homogenate

This study investigated the inhibitory effect of Cyperus esculentus L. (raw and processed) tubers on Iron (Fe2+) induced lipid peroxidation and key enzymes linked with neurodegeneration in vitro. Ten grams of tiger nut tubers was weighed and added to 100 mL of distilled water (1:10 w/v), left for 24 h, filtered, centrifuged to obtain a clear supernatant and lyophilized. Activities of acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), Fe2+-induced lipid peroxidation as well as antioxidants status as indicated by 2,2-azino-bis (3-ethylbenthiazoline-6-sulphonic acid radical scavenging ability and Fe chelation were evaluated. Raw tiger nut extracts inhibited activities of AChE and BChE in the brain tissue of rats (0 – 11.54 mg /mL) with EC50 = 3.599 mg /mL and 2.71 ± 0.01 mg /mL respectively, and increased antioxidant activity when compared with the processed tuber. Inhibition on these enzymes as well as prevention of Fe2+ induced lipid peroxidation may be the possible mechanism of action by which tiger nut prevents neurodegeneration.

INHIBITORY EFFECT OF THIOPENTONE ON THE PYRUVIC DEHYDROGENASE IN BRAIN: REVERSIBILITY OF ACTION BY THIAMINE PYROPHOSPHATE AND LIPOIC ACID

1962 ◽  
Vol 40 (1) ◽  
pp. 477-484
Author(s):  
A. R. Fahmy ◽  
H. H. Ibrahim ◽  
M. Talaat
Keyword(s):  
Brain Tissue ◽  
Lipoic Acid ◽  
Inhibitory Effect ◽  
Thiamine Pyrophosphate ◽  
Pyruvate Oxidation ◽  
Thiopentone Sodium

A study of the effect of Thiopentone sodium on pyruvate oxidation in brain tissue revealed that the action of this drug could be attributed primarily to an inhibition of pyruvic dehydrogenase, the enzyme which degrades pyruvate to the level of acetate. Of the four cofactors needed by the enzyme, thiamine pyrophosphate (TPP) and lipoic acid (Lp) modified the inhibition when added separately. The inhibition was completely relieved when thiamine pyrophosphate and lipoic acid were added together, suggesting that Thiopentone may be competing not with either alone but with a complex of the two such as "lipothiamide pyrophosphate". Alpha-Ketoglutaric dehydrogenase, which requires the same cofactors as pyruvic dehydrogenase, was somewhat less affected by Thiopentone sodium.

Sign in / Sign up

Export Citation Format

Share Document