Social exploration: When people deviate from options explored by others.

2020 ◽  
Author(s):  
Yuji K. Winet ◽  
Yanping Tu ◽  
Shoham Choshen-Hillel ◽  
Ayelet Fishbach
Keyword(s):  
Social Exploration

Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1 beta in mice

1995 ◽  
Vol 269 (1) ◽  
pp. R154-R159 ◽  
Author(s):  
E. Goujon ◽  
P. Parnet ◽  
A. Aubert ◽  
G. Goodall ◽  
R. Dantzer
Keyword(s):  
Interleukin 1 ◽  
Behavioral Effects ◽  
Protective Effects ◽  
Interleukin 1 Beta ◽  
Social Exploration ◽  
Inhibitory Feedback ◽  
Adrenal Response ◽  
Acute Injection ◽  
Progesterone Antagonist

The modulatory role of endogenous corticoids in the behavioral effects of lipopolysaccharide (LPS) and recombinant human interleukin-1 beta (IL-1 beta) was studied in mice. Adrenalectomy enhanced the depression of social exploration induced by subcutaneous injection of 200 ng of IL-1 beta or 2 micrograms of LPS. This effect was mimicked by an acute injection of the progesterone antagonist RU-38486 (0.25-1 mg). Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS. These results suggest that the pituitary-adrenal response to cytokines exerts an inhibitory feedback on the cell targets that mediate the behavioral effects of LPS and IL-1 beta.

scholarly journals Brain type I but not type II IL-1 receptors mediate the effects of IL-1β on behavior in mice

1998 ◽  
Vol 274 (3) ◽  
pp. R735-R740 ◽  
Author(s):  
Sandrine Cremona ◽  
Emmanuelle Goujon ◽  
Keith W. Kelley ◽  
Robert Dantzer ◽  
Patricia Parnet
Keyword(s):  
Monoclonal Antibody ◽  
Immune System ◽  
Behavioral Response ◽  
Behavioral Effect ◽  
Behavioral Effects ◽  
Type I ◽  
Type Ii ◽  
Social Exploration ◽  
Neutralizing Monoclonal Antibody ◽  
The Brain

In the immune system, interleukin (IL)-1β effects are mediated by the type I IL-1 receptors (IL-1RI), whereas the type II IL-1 receptors (IL-1RII) act as inhibitory receptors. IL-1RI and IL-1RII are also present in the brain. To study their functionality in the brain, mice were centrally treated with neutralizing monoclonal antibody (MAb) directed against IL-1RI (35F5, 1 μg) or against IL-1RII (4E2, 2 μg) and were centrally injected with recombinant rat IL-1β at a dose (2 ng) that decreased social exploration. Only 35F5 was effective in abrogating the behavioral effect of IL-1β. Moreover, 4E2 (1 μg icv) did not potentiate the behavioral response to a subthreshold dose of IL-1β (1 ng icv). To examine the ability of brain IL-1RI to mediate the effects of endogenous IL-1β, mice were centrally treated with 35F5 (4 μg) and peripherally injected with IL-1β (1 μg). Like IL-1 receptor antagonist (4 μg icv), 35F5 abrogated the effects of IL-1β. These results suggest that brain IL-1RI mediates the behavioral effects of IL-1β in mice.

Central mediation of the effects of interleukin-1 on social exploration and body weight in mice

1997 ◽  
Vol 22 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Rose-Marie Bluthé ◽  
Robert Dantzer ◽  
Keith W. Kelley
Keyword(s):  
Body Weight ◽  
Interleukin 1 ◽  
Social Exploration

scholarly journals Encoding of social exploration by neural ensembles in the insular cortex

2019 ◽  
Author(s):  
Isamu Miura ◽  
Masaaki Sato ◽  
Nobuo Kunori ◽  
Eric T.N. Overton ◽  
Junichi Nakai ◽  
...  
Keyword(s):  
Social Behavior ◽  
Calcium Imaging ◽  
Insular Cortex ◽  
Physical Contact ◽  
Behavioral State ◽  
Social Investigation ◽  
Brain Functions ◽  
Neural Ensembles ◽  
Social Exploration ◽  
Freely Moving

SummaryThe insular cortex participates in diverse complex brain functions including sociality, yet little is known about their cellular bases. Using microendoscopic calcium imaging of the agranular insular cortex (AI) in mice interacting with freely-moving and restrained social targets, we identified two subsets of AI neurons –a larger fraction of Social-ON cells and a smaller fraction of Social-OFF cells– that change their activity in opposite directions during social exploration. Social-ON cells included those that represented social investigation independent of location and consisted of multiple subsets, each of which were preferentially active during exploration under particular behavioral state or with a particular target of physical contact. These results uncover a previously unknown function of AI neurons in encoding conjunctive information on social behavior and suggest that AI may act to monitor the ongoing status of social exploration while an animal interacts with unfamiliar conspecifics.

scholarly journals Daily Activity of Male Mice (Mus musculus) in Laboratory

Jurnal Biota ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. 80-88
Author(s):  
Rian Oktiansyah
Keyword(s):  
Daily Activity ◽  
Sampling Method ◽  
Daily Activities ◽  
Male Mice ◽  
Additional Information ◽  
Social Exploration ◽  
Focal Animal ◽  
Pain And Suffering ◽  
Ad Libitum ◽  
Main Activity

The importance of observing the behavior of mice in the laboratory is additional information to compare with their behavior in nature and an effort to increase the welfare of mice (animal welfare) through alleviating the pain and suffering associated with scientific procedures. This study aims to study the daily activities of male mice in the laboratory. The method used was ad libitum and focal animal sampling. Based on the ad libitum sampling method, the daily activities of male mice in the laboratory were divided into 9 activities, namely locomotion, grooming, eating, foraging, social, exploration, resting, making nests, and drinking. Based on the focal animal sampling method, the main activity carried out by male mice in the laboratory was locomotion.

scholarly journals Neural Circuits for Social Interactions: From Microcircuits to Input-Output Circuits

2021 ◽  
Vol 15 ◽  
Author(s):  
Sen Xu ◽  
Ming Jiang ◽  
Xia Liu ◽  
Yahan Sun ◽  
Liang Yang ◽  
...  
Keyword(s):  
Social Behavior ◽  
Social Interactions ◽  
Molecular Mechanisms ◽  
Social Preference ◽  
Neural Circuits ◽  
Social Behaviors ◽  
Social Cues ◽  
Input Output ◽  
Social Exploration ◽  
Pathological Development

Social behaviors entail responses to social information and requires the perception and integration of social cues through a complex cognition process that involves attention, memory, motivation, and emotion. Neurobiological and molecular mechanisms underlying social behavior are highly conserved across species, and inter- and intra-specific variability observed in social behavior can be explained to large extent by differential activity of a conserved neural network. However, neural microcircuits and precise networks involved in social behavior remain mysterious. In this review, we summarize the microcircuits and input-output circuits on the molecular, cellular, and network levels of different social interactions, such as social exploration, social hierarchy, social memory, and social preference. This review provides a broad view of how multiple microcircuits and input-output circuits converge on the medial prefrontal cortex, hippocampus, and amygdala to regulate complex social behaviors, as well as a potential novel view for better control over pathological development.

Response to novelty in rats tested in isolation and in pairs: focus on exploration and play

2008 ◽  
Vol 39 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Łukasz Tanaś ◽  
Rafał Stryjek
Keyword(s):  
Wistar Rats ◽  
Social Play ◽  
Experimental Manipulation ◽  
Exploratory Activity ◽  
Experimental Chamber ◽  
The Novel ◽  
Novel Object ◽  
Social Exploration ◽  
Familiar Environment ◽  
Play Interaction

Response to novelty in rats tested in isolation and in pairs: focus on exploration and play The main goal of the study was to compare investigatory responses towards novelty in 20 Wistar rats divided into two experimental groups (solitary exploration vs. exploration in pairs). Additionally, relationship between novelty and social play/interaction was analyzed in the dyad group. Procedure involved placing animals in an experimental chamber during fifteen, six minute trials on successive days of the study. On the eleventh session a new object was introduced. The results are summarized within several behavioral categories. Investigatory responses of rats in dyad to novel object in familiar environment were not quantitatively different, than those of isolated animals. The animals from both groups responded to the novel object by focusing their exploratory activity on the source of new stimulation. Amount of social play and social exploration was influenced by the experimental manipulation with important sex differences present.

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