Patients with Parkinson’s disease display a dopamine therapy related negative bias and an enlarged range in emotional responses to facial emotional stimuli.

2017 ◽  
Vol 31 (6) ◽  
pp. 605-612 ◽  
Author(s):  
Daniel Lundqvist ◽  
Joakim Svärd ◽  
Åsa Michelgård Palmquist ◽  
Håkan Fischer ◽  
Per Svenningsson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Emotional Responses ◽  
Negative Bias ◽  
Emotional Stimuli

Blunted responses to emotional stimuli in Parkinson's disease: An EEG study of visual affective word processing

2013 ◽  
Vol 333 ◽  
pp. e94
Author(s):  
N. Dissanayaka ◽  
T. Au ◽  
A. Angwin ◽  
J. O'Sullivan ◽  
G. Byrne ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Word Processing ◽  
Emotional Stimuli ◽  
Affective Word

scholarly journals The impact of non-motor manifestations of Parkinson's disease on partners: understanding and application of chronic sorrow theory

2015 ◽  
Vol 7 (3) ◽  
pp. 221 ◽  
Author(s):  
Christine Mercer
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Support Group ◽  
Health Professionals ◽  
Emotional Responses ◽  
Chronic Sorrow ◽  
Effect Of Pd ◽  
The Impact ◽  
Insight Into ◽  
Physical Care

INTRODUCTION: Parkinson's disease (PD) can cause many emotions, including grief and a sense of isolation for both the person with PD (referred to as Parkinsonian) and their partner. Such ongoing grief and emotional turmoil can be termed chronic sorrow. The aim of this research is to present accounts of partners' perspectives, analysed in the context of chronic sorrow theory, to offer health professionals an insight into the impact of non-motor PD symptoms on partners. METHODS: A group of partners of Parkinsonians provided the data through individual stories. These stories were subjected to thematic analysis, using a seven-step process leading to the establishment of themes. FINDINGS: Caregiver burden and chronic sorrow is not related to providing physical care, but the emotional care of attempting to minimise the effect of PD, coping with disturbance to sleep, and helping the Parkinsonian to maintain as much independence as possible. Contributors to this article found chronic sorrow theory provided a framework for understanding their emotions. Sharing their experiences with others provided an opportunity to be heard, and enabled them to make sense of individual situations. CONCLUSION: Chronic sorrow theory provides a useful framework for both partners of Parkinsonians in understanding their emotional responses, and for health professionals in considering the challenges partners face in coping with living with a person with PD. KEYWORDS: Grief; Parkinson's disease; support group; support partners; symptoms

scholarly journals PET Studies of Net Blood—Brain Clearance of FDOPA to Human Brain: Age-Dependent Decline of [18F]Fluorodopamine Storage Capacity

2005 ◽  
Vol 25 (7) ◽  
pp. 807-819 ◽  
Author(s):  
Yoshitaka Kumakura ◽  
Ingo Vernaleken ◽  
Gerhard Gründer ◽  
Peter Bartenstein ◽  
Albert Gjedde ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Storage Capacity ◽  
Compartmental Analysis ◽  
Graphical Analysis ◽  
Negative Bias ◽  
Precursor Pool ◽  
Healthy Elderly ◽  
Age Related ◽  
The Brain

Conventional methods for the graphical analysis of 6-[18F]fluorodopa (FDOPA)/positron emission tomography (PET) recordings ( Kappin) may be prone to negative bias because of oversubtraction of the precursor pool in the region of interest, and because of diffusion of decarboxylated FDOPA metabolites from the brain. These effects may reduce the sensitivity of FDOPA/PET for the detection of age-related changes in dopamine innervations. To test for these biasing effects, we have used a constrained compartmental analysis to calculate the brain concentrations of the plasma metabolite 3- O-methyl-FDOPA (OMFD) during 120 mins of FDOPA circulation in healthy young, healthy elderly, and Parkinson's disease subjects. Calculated brain OMFD concentrations were subtracted frame-by-frame from the dynamic PET recordings, and maps of the FDOPA net influx to brain were calculated assuming irreversible trapping ( Kapp). Comparison of Kappin and Kapp maps revealed a global negative bias in the conventional estimates of FDOPA clearance. The present OMFD subtraction method revealed curvature in plots of Kapp at early times, making possible the calculation of the corrected net influx ( K) and also the rate constant for diffusion of decarboxylated metabolites from the brain ( kloss). The effective distribution volume (EDV2; K/ kloss) for FDOPA, an index of dopamine storage capacity in brain, was reduced by 85% in putamen of patients with Parkinson's disease, and by 58% in the healthy elderly relative to the healthy young control subjects. Results of the present study support claims that storage capacity for dopamine in both caudate and putamen is more profoundly impaired in patients with Parkinson's disease than is the capacity for DOPA utilization, calculated by conventional FDOPA net influx plots. The present results furthermore constitute the first demonstration of an abnormality in the cerebral utilization of FDOPA in caudate and putamen as a function of normal aging, which we attribute to loss of vesicular storage capacity.

Stress-evoking emotional stimuli exaggerate deficits in motor function in Parkinson's disease

2018 ◽  
Vol 112 ◽  
pp. 66-76 ◽  
Author(s):  
R.L. Blakemore ◽  
M.R. MacAskill' ◽  
R. Shoorangiz ◽  
T.J. Anderson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Function ◽  
Emotional Stimuli

scholarly journals Changes in Emotional Regulation May Underlie Emotional Changes in Early Parkinson’s Disease Progression: A Multimodal Study.

2020 ◽  
Author(s):  
Allison Eriksson ◽  
Panagiota Tsitsi ◽  
Mikkel C. Vinding ◽  
Martin Ingvar ◽  
Per Svenningsson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Emotional Regulation ◽  
Emotional Processing ◽  
Neurodegenerative Disorder ◽  
Early Stage ◽  
Healthy Controls ◽  
Emotional Stimuli ◽  
General Increase ◽  
Early Parkinson’S Disease

Parkinson’s Disease (PD) is a neurodegenerative disorder which can substantially affect nonmotor functions related to emotional processing. However, previous studies investigating the effects of PD on emotional processing have produced conflicting results. In the current study, we aimed to examine the underlying differences in emotional processing in PD by comparing how early-stage PD patients rate and react to emotional stimuli in three modalities on an Emotion Survey. Data analysis focused on identifying differences in emotion recognition, bias, and emotional range together with clinical outcome measures. Our results showed that PD patients were more accurate than healthy controls at identifying correct emotions. Furthermore, when clinical scores were correlated with ratings of emotional stimuli, PD patients alone showed a general increase in ratings and reactions to both positive and negative stimuli, thereby yielding significant correlations between clinical outcomes and emotional range in the PD patient group. Our results suggest that alterations in emotional regulation may underlie changes in emotional processing in early PD.

‘AEGON’ Project: Auditory-emotional stimuli and gait in Parkinson's disease

2019 ◽  
Vol 74 ◽  
pp. 23
Author(s):  
T. Lencioni ◽  
C. Cosentino ◽  
T. Bowman ◽  
I. Carpinella ◽  
A. Marzegan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Emotional Stimuli
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