Differential maturation of an adrenal response to cold stress in rats manipulated in infancy.

1958 ◽  
Vol 51 (6) ◽  
pp. 774-777 ◽  
Author(s):  
Seymour Levine ◽  
Morton Alpert ◽  
George W. Lewis
Keyword(s):  
Cold Stress ◽  
Adrenal Response

ACCLIMATIZATION TO COLD: OBSERVATIONS ON THE MECHANISM OF THE REDUCED IMMEDIATE ADRENAL RESPONSE

1959 ◽  
Vol 37 (1) ◽  
pp. 671-677
Author(s):  
Doris Nicholls ◽  
Rosemary Molloy ◽  
Kathleen Stavraky ◽  
R. J. Rossiter
Keyword(s):  
Adrenal Gland ◽  
Peripheral Nerve ◽  
Cold Stress ◽  
Cold Exposure ◽  
Inorganic Phosphorus ◽  
Phosphorus Metabolism ◽  
Adrenal Tissue ◽  
Adrenal Response

The incorporation of inorganic phosphorus labelled with P32 into the inorganic phosphorus of the adrenal gland was measured in rats acclimatized to cold for 4 weeks. Previously it was reported that the immediate pituitary–adrenal response to brief cold exposure (2 hours at −5 °C), as judged by the increased P32 incorporation is considerably decreased in rats that have been acclimatized. Some observations are now reported on the mechanism of this reduced immediate response.The administration of ACTH, pitressin, or adrenaline caused similar increases in the adrenal phosphorus metabolism in acclimatized and non-acclimatized control rats. Acclimatization could still be demonstrated in rats after the fur had been removed by clipping.From these results it is concluded that the decreased immediate pituitary–adrenal response to an exposure to more severe cold, observed in acclimatized rats, is not the result of an increased fur thickness, nor is it the result of a decreased sensitivity of the adrenal tissue to ACTH, or to a decreased sensitivity of the pituitary or hypothalamus to a given stimulus. It is suggested that the reduction in the immediate pituitary–adrenal response to a more severe cold stress in acclimatized rats might be due to an alteration in the sensitivity of the peripheral nerve receptors, or in the mechanism, nervous or otherwise, whereby the pituitary is stimulated.

ACCLIMATIZATION TO COLD: OBSERVATIONS ON THE MECHANISM OF THE REDUCED IMMEDIATE ADRENAL RESPONSE

1959 ◽  
Vol 37 (5) ◽  
pp. 671-677 ◽  
Author(s):  
Doris Nicholls ◽  
Rosemary Molloy ◽  
Kathleen Stavraky ◽  
R. J. Rossiter
Keyword(s):  
Adrenal Gland ◽  
Peripheral Nerve ◽  
Cold Stress ◽  
Cold Exposure ◽  
Inorganic Phosphorus ◽  
Phosphorus Metabolism ◽  
Adrenal Tissue ◽  
Adrenal Response

The incorporation of inorganic phosphorus labelled with P32 into the inorganic phosphorus of the adrenal gland was measured in rats acclimatized to cold for 4 weeks. Previously it was reported that the immediate pituitary–adrenal response to brief cold exposure (2 hours at −5 °C), as judged by the increased P32 incorporation is considerably decreased in rats that have been acclimatized. Some observations are now reported on the mechanism of this reduced immediate response.The administration of ACTH, pitressin, or adrenaline caused similar increases in the adrenal phosphorus metabolism in acclimatized and non-acclimatized control rats. Acclimatization could still be demonstrated in rats after the fur had been removed by clipping.From these results it is concluded that the decreased immediate pituitary–adrenal response to an exposure to more severe cold, observed in acclimatized rats, is not the result of an increased fur thickness, nor is it the result of a decreased sensitivity of the adrenal tissue to ACTH, or to a decreased sensitivity of the pituitary or hypothalamus to a given stimulus. It is suggested that the reduction in the immediate pituitary–adrenal response to a more severe cold stress in acclimatized rats might be due to an alteration in the sensitivity of the peripheral nerve receptors, or in the mechanism, nervous or otherwise, whereby the pituitary is stimulated.

DETERMINATION OF BLOOD CORTICOIDS USING THE IN VITRO RESIN UPTAKE OF 3H-PREDNISOLONE

1968 ◽  
Vol 57 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Hironori Nakajima ◽  
Mitsunori Murala ◽  
Masumitsu Nakata ◽  
Takeshi Naruse ◽  
Seiji Kubo
Keyword(s):  
Thyroid Function Test ◽  
Normal Subjects ◽  
Adrenal Function ◽  
Function Test ◽  
Before And After ◽  
Adrenal Response ◽  
Suppression Test

ABSTRACT The in vitro resin uptake of 3H-prednisolone was used for the determination of blood cortisol after addition of radioactive prednisolone followed by Amberlite CG 400 Type 1 to the test serum, and incubation of the mixture. The radioactivity of the supernatant was compared before and after the addition of the resin. The principle of this method is similar to that of the 131I-triiodothyronine resin uptake for the thyroid function test. The tests for the specificity, reproducibility and sensitivity gave satisfactory results. The mean basal value ± SD of the 3H-prednisolone resin uptake was 35.3 ± 9.2% in normal subjects, and 27.1 ± 4.8% in pregnant women. This method was valid in various adrenal function tests, i. e. the adrenal circadian rhythm, corticotrophin (ACTH) test, dexamethasone suppression test and the adrenal response to lysine-8-vasopressin. It proved to be a sensitive indicator of the adrenal function. These results suggest that this method should be useful for a routine adrenal function test.

Pathological features of the Florida manatee cold stress syndrome

2003 ◽  
Vol 29 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Gregory D. Bossart ◽  
René A. Meisner ◽  
S. A. Rommel ◽  
Shin-Je Ghim ◽  
A. Bennett Jenson
Keyword(s):  
Cold Stress ◽  
Pathological Features ◽  
Florida Manatee ◽  
Stress Syndrome
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