Clinical Investigations of Drug Effects in Women

Drug Effects and Clinical Investigations for Contrast-Induced Nephropathy After Coronary Angiography or Percutaneous Coronary Intervention in Patients With Diabetes

American Journal of Therapeutics ◽

10.1097/mjt.0000000000000325 ◽

2017 ◽

Vol 24 (4) ◽

pp. e423-e430 ◽

Cited By ~ 3

Author(s):

Man-Man Zhang ◽

Qian-Zhou Lv ◽

Xiao-Ye Li

Keyword(s):

Percutaneous Coronary Intervention ◽

Coronary Angiography ◽

Drug Effects ◽

Coronary Intervention ◽

Contrast Induced Nephropathy ◽

Clinical Investigations ◽

Percutaneous Coronary ◽

Patients With Diabetes

Download Full-text

Clinical investigations of drug effects in women.

PsycEXTRA Dataset ◽

10.1037/e468302004-001 ◽

1986 ◽

Author(s):

Jack H. Mendelson ◽

Nancy K. Mello

Keyword(s):

Drug Effects ◽

Clinical Investigations

Download Full-text

Thalamic deep brain stimulation as a paradigm to reduce consciousness: implications for cortico-striatal dynamics, absence epilepsy and consciousness studies

10.1101/2021.07.27.453855 ◽

2021 ◽

Author(s):

Michelle J Redinbaugh ◽

Mohsen Afrasiabi ◽

Jessica M Phillips ◽

Niranjan A Kambi ◽

Sounak Mohanta ◽

...

Keyword(s):

Deep Brain Stimulation ◽

Brain Stimulation ◽

Low Frequency ◽

Drug Effects ◽

Absence Epilepsy ◽

Subcortical Structures ◽

Low Frequencies ◽

Clinical Investigations ◽

Power Spectral ◽

Deep Brain

Anesthetic manipulations provide much-needed causal evidence for neural correlates of consciousness, but nonspecific drug effects complicate their interpretation. Evidence suggests that thalamic deep brain stimulation (DBS) can either increase or decrease consciousness, depending on the stimulation target and parameters. The putative role of the central lateral thalamus (CL) in consciousness makes it an ideal DBS target to manipulate circuit-level mechanisms in corticostriatothalamic (CST) systems, thereby influencing consciousness and related processes. We used multimicroelectrode DBS targeted to CL in macaques while recording from frontal, parietal, and striatal regions. DBS induced episodes reminiscent of absence epilepsy, here termed absence-like activity (ALA), with decreased behavior and vacant staring coinciding with low-frequency oscillations. DBS modulated ALA likelihood in a frequency-specific manner. ALA events corresponded to decreases in measures of neural complexity (entropy) and integration (Phi*), an index of consciousness, and substantial changes to communication in CST circuits. During ALA, power spectral density and coherence at low frequencies increased across CST circuits, especially in thalamoparietal and corticostriatal pathways. Decreased consciousness and neural integration corresponded to shifts in corticostriatal network configurations that dissociated parietal and subcortical structures. Overall, the features of ALA and implicated networks were similar to those of absence epilepsy. As this same multimicroelectrode DBS method, but at different stimulation frequencies, can also increase consciousness in anesthetized macaques, it can be used to flexibly address questions of consciousness with limited confounds, as well as inform clinical investigations of absence epilepsy and other consciousness disorders.

Download Full-text

Reduction in Pain Sensitivity from Pharmacological Elevation of Blood Pressure in Persons with Chronically Low Blood Pressure

Journal of Psychophysiology ◽

10.1027/0269-8803.23.3.104 ◽

2009 ◽

Vol 23 (3) ◽

pp. 104-112 ◽

Cited By ~ 12

Author(s):

Stefan Duschek ◽

Heike Heiss ◽

Boriana Buechner ◽

Rainer Schandry

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Pain Sensitivity ◽

Pain Threshold ◽

Pain Perception ◽

Drug Effects ◽

Pressure Effects ◽

Double Blind ◽

Low Blood Pressure ◽

Present Trial

Recent studies have revealed evidence for increased pain sensitivity in individuals with chronically low blood pressure. The present trial explored whether pain sensitivity can be reduced by pharmacological elevation of blood pressure. Effects of the sympathomimetic midodrine on threshold and tolerance to heat pain were examined in 52 hypotensive persons (mean blood pressure 96/61 mmHg) based on a randomized, placebo-controlled, double-blind design. Heat stimuli were applied to the forearm via a contact thermode. Confounding of drug effects on pain perception with changes in skin temperature, temperature sensitivity, and mood were statistically controlled for. Compared to placebo, higher pain threshold and tolerance, increased blood pressure, as well as reduced heart rate were observed under the sympathomimetic condition. Increases in systolic blood pressure between points of measurement correlated positively with increases in pain threshold and tolerance, and decreases in heart rate were associated with increases in pain threshold. The findings underline the causal role of hypotension in the augmented pain sensitivity related to this condition. Pain reduction as a function of heart rate decrease suggests involvement of a baroreceptor-related mechanism in the pain attrition. The increased proneness of persons with chronic hypotension toward clinical pain is discussed.

Download Full-text